Reduction of hepatitis C virus NS5A phosphorylation through its interaction with amphiphysin II

Biochemical and Biophysical Research Communications

Volumn 336, Issue 2, 2005, Pages 572-578

  Masumi, Atsuko ^a   Aizaki, Hideki ^a   Suzuki, Tetsuro ^a   DuHadaway, James B ^b   Prendergast, George C ^b   Komuro, Katsutoshi ^a   Fukazawa, Hidesuke ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Amphiphysin II; HCV; NS5A; Phosphorylation; Proteome

Indexed keywords

AMPHIPHYSIN; NONSTRUCTURAL PROTEIN 5A; PHOSPHOPROTEIN; PHOSPHOTRANSFERASE; RNA; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

ARTICLE; ENZYME ASSAY; HEPATITIS C VIRUS; LIFE CYCLE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; RNA REPLICATION; SRC HOMOLOGY DOMAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BINDING SITES; CARRIER PROTEINS; HELA CELLS; HUMANS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; TUMOR SUPPRESSOR PROTEINS; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; MAMMALIA;

EID: 24644471566     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.08.142     Document Type: Article

References (32)

1. N. Akuta, F. Suzuki, A. Tsubota, Y. Suzuki, T. Hosaka, T. Someya, M. Kobayashi, S. Saitoh, Y. Arase, K. Ikeda, and H. Kumada Association of amino acid substitution pattern in nonstructural protein 5A of hepatitis C virus genotype2a low viral load and response to interferon monotherapy J. Med. Virol. 69 2003 376 383
2. S. Nishiguchi, T. Ueda, T. Ito, M. Enomoto, M. Tanaka, N. Tatsumi, K. Fukuda, A. Tamori, D. Habu, T. Takeda, S. Otani, and S. Shiomi Method to detect substitutions in the interferon-sensitivity-determining region of hepatitis C virus 1b for prediction of response to interferon therapy Hepatology 33 2001 241 247
3. M.S. De Mitri, G. Morsica, R. Cassini, S. Bagaglio, M. Zoli, A. Alberti, and M. Bernardi Prevalence of wild-type in NS5A-PKR protein kinase binding domain in HCV-related hepatocellular carcinoma J. Hepatol. 36 2002 116 122
4. J.R. Gale, M.J. Korth, N.M. Tang, S.-L. Tan, D.A. Hopkins, T.E. Dever, S.J. Polyak, D.R. Gretch, and M.G. Katze Evidence that hepatitis C virus resistance to interferon is mediated through repression of PKR protein kinase by the nonstructural 5A protein Virology 230 1997 217 227
5. S. Polyak, K.S. Khabar, D.M. Paschal, H.J. Ezelle, G. Duverlie, G.N. Barber, D.E. Levy, N. Mukaida, and D.R. Gretch Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response J. Virol. 75 2001 6095 6106
6. S.-L. Tan, H. Nakao, Y. He, S. Vijayri, P. Neddermann, B.L. Jacobs, B.J. Mayer, and M.G. Katze NS5A, a nonstructural protein of hepatitis C virus virus, binds growth factor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling Proc. Natl. Acad. Sci. USA 96 1999 5533 5538
7. K.H. Lan, M.L. Sheu, S.J. Hwang, S.H. Yen, S.Y. Chen, J.C. Wu, Y.J. Wang, N. Kato, M. Omata, F.Y. Chang, and S.D. Lee HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis Oncogene 18 2002 4801 4811
8. I. Qadri, M. Iwahashi, and F. Simon Hepatitis C virus NS5A binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3 Biochim. Biophys. Acta 1592 2002 193 204
9. K.M. Chung, J. Lee, J.E. Kim, O.K. Song, S. Cho, J. Lim, M. Seedorf, B. Hahm, and S.K. Jang Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta3 J. Virol. 74 2000 5333 5341
10. K. Park, S. Choi, D. Choi, J. Park, S. Yie, S. Lee, and S. Hwang Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor 2 J. Biol. Chem. 278 2003 30711 30718
11. A.K. Ghosh, M. Majumder, R. Steele, R. Ray, and R.B. Ray Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein Pitx1 Virology 306 2003 51 59
12. H. Tu, L. Gao, S.T. Shi, D.R. Taylor, T. Yang, A.K. Mircheff, Y. Wen, A.E. Gorbalenya, S.B. Hwang, and M.M. Lai Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein Virology 263 1999 30 41
13. L. Gao, H. Aizaki, J. He, and M. Lai Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft J. Virol. 78 2004 3480 3488
14. J.B. DuHadaway, D. Sakamuro, D.L. Ewert, and G.C. Prendergast Bin1 mediates apoptosis by c-Myc in transformed primary cells Cancer Res. 61 2001 3151 3156
15. B. Zech, A. Kurtenbach, N. Krieger, D. Strand, S. Blencke, M. Morbitzer, K. Salassidis, M. Cotten, J. Wissing, S. Obert, R. Bartenschlager, T. Herget, and H. Daub Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A protein J. Gen. Virol. 84 2003 555 560
16. K.E. Reed, J. Xu, and C.M. Rice Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase J. Virol. 71 1997 7187 7197
17. L. Huang, E.V. Sineva, M.R. Hargittai, S.D. Sharma, M. Suthar, K.D. Raney, and C.E. Cameron Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli Protein Expr. Purif. 37 2004 144 153
18. P. Neddermann, M. Quintavalle, C. Di Pietro, A. Clementi, M. Cerretani, S. Altamura, L. Bartholomew, and R. De Francesco Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture J. Viol. 78 2004 13306 13314
19. M.J. Evans, C.M. Rice, and S.P. Goff Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication Proc. Natl. Acad. Sci. USA 101 2004 13038 13043
20. H. Aizaki, Y. Aoki, T. Harada, K. Ishii, T. Suzuki, S. Nagamori, G. Toda, Y. Matsuura, and T. Miyamura Full-length complementary DNA of hepatitis C virus genome from an infectious blood sample Hepatology 27 1998 621 627
21. H. Aizaki, S. Saito, T. Ogino, N. Miyajima, T. Harada, Y. Matsuura, T. Miyamura, and M. Kohase Suppression of interferon-induced antiviral activity in cells expressing hepatitis C virus proteins J. Interferon Cytokine Res. 20 2000 1111 1120
22. D. Sakamuro, K.J. Elliott, R. Wechsler-Reya, and G.C. Prendergast Bin1 is a novel MYC-interacting protein with features of a tumour suppressor Nat. Genet. 14 1996 69 77
23. K. Reed, and C. Rice Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321 J. Biol. Chem. 274 1999 28011 28018
24. A. Pineda-Lucena, and C.H. Arrowsmith Letter to the Editor: 1H, 13C and 15N resonance assignments and secondary structure of the c-Myc binding domain (MBD) and the SH3 domain of the tumor suppressor Bin1 J. Biomol. NMR 19 2001 191 192
25. E. Lee, M. Marcucci, L. Daniell, M. Pypaert, O.A. Weisz, G.C. Ochoa, K. Farsad, M.R. Wenk, P. De Camilli, Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle, Science 297 (2002) 1193-1196.
26. R.J. Wechsler-Reya, K.J. Elliott, and G.C. Prendergast A role for the putative tumor suppressor Bin1 in muscle cell differentiation Mol. Cell. Biol. 18 1998 566 575
27. A. Macdonald, K. Crowder, A. Street, C. McCormick, and M. Harris The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity J. Gen. Virol. 85 2004 721 729
28. G.K. Geiss, V.S. Carter, Y. He, B.K. Kwieciszewski, T. Holzman, M.J. Korth, C.A. Lazaro, N. Fausto, R.E. Bumgarner, and M.G. Katze Gene expression of profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attention by the hepatitis C virus nonstructural 5A protein J. Virol. 77 2003 6367 6375
29. G. Dumenil, J.C. Olivo, S. Pellegrini, M. Fellous, P.J. Sansonetti, and G.T. Nhieu Interferon alpha inhibits a Src-mediated pathway necessary for Shigella-induced cytoskeletal rearrangements in epithelial cells J. Cell Biol. 143 1998 1003 1012
30. G. Waris, A. Livols, V. Imbert, J.-F. Peyron, and A. Siddiqui Hepatitis C virus NS5A and subgenomic replicon activate NF-kB via tyrosine phosphorylation of IkB and its degradation by Calpain J. Biol. Chem. 278 2003 40778 40787
31. Y. Ide, A. Tanimoto, Y. Sasaguri, and R. Padmanabhan Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound kinase from HeLa cells and by cAMP-dependent protein kinase A-a catalytic subunit Gene 201 1997 151 158
32. J. Kim, D. Lee, and J. Choe Hepatitis C virus NS5A protein is phosphorylated by casein kinase II Biochem. Biophys. Res. Commun. 257 1999 777 781