Activation induced cytidine deaminase expression in lymphocyte predominant Hodgkin lymphoma

Journal of Clinical Pathology

Volumn 58, Issue 9, 2005, Pages 1002-1004

  Mottok, A ^a   Hansmann, M L ^a   Brauninger A ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE DEAMINASE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HODGKIN DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE; MICROMANIPULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SOMATIC HYPERMUTATION; TUMOR CELL;

CYTIDINE DEAMINASE; ENZYME ACTIVATION; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; HODGKIN DISEASE; HUMANS; MICROMANIPULATION; POLYMERASE CHAIN REACTION; RNA, RIBOSOMAL, 18S; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 24644456553     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2005.026252     Document Type: Article

References (11)

1. Hansmann ML, Weiss LM, Stein H, et al. Pathology of lymphocyte predominance Hodgkin's disease. In: Mauch PM, Armitage JO, Diehl V, et al, eds. Hodgkin's disease. Philadelphia: Lippincott Williams Wilkins, 1999:168-90.
2. Küppers R, Rajewsky K, Zhao M, et al. Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci U S A 1994;91:10962-6.
3. Braeuninger A, Küppers R, Strickler JG, et al. Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells. Proc Natl Acad Sci U S A 1997;94:9337-42.
4. Marafioti T, Hummel M, Anagnostopoulos I, et al. Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells. N Engl J Med 1997;337:453-8.
5. Klein U, Goossens T, Fischer M, et al. Somatic hypermutation in normal and transformed human B cells. Immunol Rev 1998;162:261-80.
6. Muramatsu M, Kinoshita K, Fagarasan S, et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000;102:553-63.
7. Pasqualucci L, Guglielmino R, Houldsworth J, et al. Expression of the AID protein in normal and neoplastic B cells. Blood 2004;104:3318-25.
8. Smit LA, Bende RJ, Aten J, et al. Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype. Cancer Res 2003;63:3894-8.
9. Losses IS, Levy R, Alizadeh AA. AID is expressed in germinal center B-cell-like and activated B-cell-like diffuse large-cell lymphomas and is not correlated with intraclonal heterogeneity. Leukemia 2004;18:1775-9.
10. Forconi F, Sahota SS, Raspadori D, et al. Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch. Blood 2004;104:3312-17.
11. Aarts WM, Bende RJ, Steenbergen EJ, et al. Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load. Blood 2000;95:2922-9.