Isolation of Candida albicans chitin synthase 1 inhibitor from Streptomyces sp. A6705 and its characterization

Journal of Microbiology and Biotechnology

Volumn 15, Issue 4, 2005, Pages 895-898

  Kim, Na Rae ^a   Hwang, Eui Il ^b   Yun, Bong Sik ^a   Lee, Sang Han ^a   Moon, Jae Sun ^a   Lim, Chi Hwan ^c   Lim, Se Jin ^d   Kim, Sung Uk ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b KT and G Corporation   (South Korea)

^c Chungnam National University   (South Korea)

^d Dongduk Women's University   (South Korea)

Author keywords

Candida albicans; Chemotaxonomy; Chitin synthase 1 inhibitor; N; N bis(2 phenylethyl)urea

Indexed keywords

ANTIFUNGAL AGENT; CHITIN SYNTHASE; CHITIN SYNTHASE 1 INHIBITOR; GLYCOSYLTRANSFERASE INHIBITOR; N,N BIS(2 PHENYLETHYL)UREA; POLYOXIN D; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CHEMICAL ANALYSIS; CHROMATOGRAPHY; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME STRUCTURE; HYPHOMYCETES; IC 50; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; SPECIES; STREPTOMYCES; ULTRAVIOLET SPECTROPHOTOMETRY;

CANDIDA ALBICANS; FILOBASIDIELLA NEOFORMANS; SACCHAROMYCES CEREVISIAE; STREPTOMYCES SP.;

EID: 24644449193     PISSN: 10177825     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Sudoh, M., K. Tatsuno, N. Ono, A. Ohta, H. Chibana, H. Yamada-Okabe, and M. Arisawa. 1999. The Candida albicans CHS4 gene complements a Saccharomyces cerevisiae Skt5/chs4 mutation and is involved in chitin biosynthesis. Microbiology 145: 1613-1622.
2. Sudoh, M., T. Yamazaki, K. Masubuchi, M. Taniguchi, N. Shimma, M. Arisawa, and H. Yamada-Okabe. 2000. Identification of a novel inhibitor specific to the fungal chitin synthase. J. Biol. Chem. 275: 32901-32905.
3. Chiou, C. C., A. H. Groll, and T. J. Walsh. 2000. New drugs and novel targets for treatment of invasive fungal infections in patients with cancer. Oncologist 5: 120-135.
4. Jiang, B., H. Bussey, and I Roemer. 2002. Novel strategies in antifungal lead discovery. Curr. Opin. Microbiol. 5: 466-471.
5. Bulawa, C. E. 1993. Genetics and molecular biology of chitin synthesis in fungi. Annu. Rev. Microbiol. 47: 505-534.
6. Au-Young, J. and P. W. Robbins. 1990. Isolation of a chitin synthetase gene (CHS1) from Candida albicans by expression in Saccharomyces cerevisiae. Mol. Microbiol. 4: 197-207.
7. Mio, T., T. Yabe, M. Sudoh, Y. Satoh, T. Nakajima, M. Arisawa, and H. Yamada-Okada. 1996. Role of three chitin synthase genes in the growth of Candida albicans. J. Bacteriol. 178: 2416-2419.
8. Munro, C. A., K. Winter, A. Buchan, and N. A. R. Gow. 2001. Chs 1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity. Mol. Microbiol. 39: 1414-1426.
9. Munro. C. A. and N. A. R. Gow. 1995. Chitin biosynthesis as a target for antifungals, pp. 161-171. In G. K. Dixon, L. G. Copping, and D. W. Hollomon (eds.), Antifungal Agents: Discovery and Mode of Action. Bios Scientific Publisher, Oxford, U.K.
10. Orlean, P. 1987. Two chitin synthases in Saccharomyces cerevisiae. J. Biol. Chem. 262: 5732-5739.
11. Choi, W. J. 1998. The determination of chitin synthases by varying pH and divalent cations in Candida albicans. J. Microbiol. Biotechnol. 8: 613-617.
12. Hwang, E. I., B. M. Kwon, S. H. Lee, N. R. Kim, T. H. Kang, Y. T. Kim, B. K. Park, and S. U. Kim. 2002. Obovatols, new chitin synthase 2 inhibitors of Saccharomyces cerevisiae from Magnolia obovata. J. Antimicrob. Chemother. 49: 95-101.
13. Mcginnis, M. R. and M. G. Rinaldi. 1986. Antifungal drugs: Mechanisms of action, drug resistance, susceptibility testing, and assays of activity in biological fluids, pp. 223-281. In L. Victor (ed.), Antibiotics in Laboratory Medicine, 2nd ed. Williams and Wilkins, Baltimore, U.S.A.
14. Locci, R. 1989. Streptomycetes and related genera, pp. 2451-2492. In S. T. Williams, M. E. Sharpe, and J. G. Holt (eds.), Bergey's Manual of Systematic Bacteriology, Vol. 4. Williams and Wilkins, Baltimore, U.S.A.
15. Daoud, N. N. and H. A. Foster. 1993. Antifungal activity of Myxococcus species. 1 Production, physicochemical and biological properties of antibiotics from Myxococcus fulvus S110 (Myxobacterales). Microbios 73: 173-184.
16. Iwai, Y., A. Hirano, J. Awaya, S. Matsuo, and S. Omura. 1978. 1,3-Diphenethylurea from Streptomyces sp. No. AM-2498. J. Antibiot. 31: 375-376.
17. Park, K. S., K. C. Kang, J. H. Kim, D. J. Adams, T. N. Johng, and Y. K. Paik. 1999. Differential inhibitory effects of protoberberines on sterol and chitin biosyntheses in Candida albicans. J. Antimicrob. Chemother. 43: 667-674.
18. Park, K. S., K. C. Kang, K. Y. Kim, P. Y. Jeong, J. H. Kim, D. J. Adams, J. H. Kim, and Y. K. Paik. 2001. HWY-289, a novel semi-synthetic protoberberine derivative with multiple target sites in Candida albicans. J. Antimicrob. Chemother. 47: 513-519.