The arbitrariness of the genetic code

Biology and Philosophy

Volumn 19, Issue 2, 2004, Pages 205-222

  Stegmann, Ulrich E ^a  

^a BIELEFELD UNIVERSITY   (Germany)

Author keywords

Allosteric effectors; Arbitrariness; Competitive inhibition; Complementarity; Evolutionary contingency; Frozen accident theory; Genetic code; Genetic information; Principles of chemistry

Indexed keywords

GENETICS;

EID: 2442706284     PISSN: 01693867     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:BIPH.0000024412.82219.a6     Document Type: Article

References (27)

1. Beatty J.: 1995, 'The Evolutionary Contingency Thesis', in Wolters G. and Lennox J.G. (eds.), Concepts, Theories and Rationality in the Biological Sciences, University of Pittsburgh Press, Pittsburgh, pp. 45-81.
2. Christie M. and Christie J.R.: 2000, ' "Laws" and "Theories" in Chemistry Do Not Obey the Rules', in Bhushan N. and Rosenfeld S. (eds.), Of Minds and Molecules: New Philosophical Perspectives on Chemistry, Oxford University Press, Oxford, pp. 34-50.
3. Crick F.H.: 1968, 'The Origin of the Genetic Code', Journal of Molecular Biology 38, 367-379.
4. Crick F.H.: 1970, 'Central Dogma of Molecular Biology', Nature 227, 561-563.
5. Ellington A.D., Khrapov M. and Shaw C.A.: 2000, 'The Scene of a Frozen Accident', RNA-A Publication of the RNA Society 6(4), 485-498.
6. Godfrey-Smith P.: 1999, 'Genes and Codes: Lessons from the Philosophy of Mind?', in Hardcastle V. (ed.), Biology Meets Psychology: Constraints, Conjectures, Connections, MIT Press, Cambridge, MA, pp. 305-311.
7. Godfrey-Smith P.: 2000a, 'Information, Arbitrariness, and Selection: Comments on Maynard Smith', Philosophy of Science 67, 202-207.
8. Godfrey-Smith P.: 2000b, 'On the Theoretical Role of "Genetic Coding"', Philosophy of Science 67, 26-44.
9. Henikoff S.: 2002, 'Editorial - Beyond the Central Dogma', Bioinformatics 18 (2), 223-225.
10. Illangasekare M. and Yarus M.: 2002, 'Phenylalanine-binding RNAs and Genetic Code Evolution', Journal of Molecular Evolution 54 (3), 298-311.
11. Jacob F.: 1974, The Logic of Living Systems - A History of Heredity, Allen Lane, London. Transl. of Jacob 1970, La Logique du vivant; une histoire de l'hérédité. Éditions Gallimard, Paris.
12. Jacob F. and Monod J.: 1963, 'Genetic Repression, Allosteric Inhibition, and Cellular Differentiation', in Locke M. (eds.), Cytodifferentiation and Macromolecular Synthesis, Academic Press, New York, pp. 30-64.
13. Keyes M.E.: 1999, 'The Prion Challenge to the "Central Dogma" of Molecular Biology, 1965-1991. Part I: Prelude to Prions', Studies in the History and Philosophy of Biology and Biomedical Sciences 30 (1), 1-19.
14. Knight R.D., Freeland S.J. and Landweber L.F.: 1999, 'Selection, History and Chemistry: The Three Faces of the Genetic Code', Trends in Biochemical Science 24, 241-247.
15. Knight R.D., Freeland S.J. and Landweber L.F.: 2001, 'Rewiring the Keyboard: Evolvability of the Genetic Code', Nature Reviews Genetics 2, 49-58.
16. Maynard Smith J.: 2000a, 'The Concept of Information in Biology', Philosophy of Science 67, 177-194.
17. Maynard Smith J.: 2000b, 'Reply to Commentaries', Philosophy of Science 67, 214-218.
18. Maynard Smith J. and Szathmáry E.: 1995, The Major Transitions in Evolution, Oxford University Press, Oxford.
19. Monod J.: 1971, Chance and Necessity, Collins, London. Transl. of Monod, 1970, Le hasard et la necessité. Édition du Seuil, Paris.
20. Monod J., Changeux J.-P. and Jacob F.: 1963, 'Allosteric Proteins and Cellular Control Systems', Journal of Molecular Biology 6, 306-329.
21. Monod J. and Jacob F.: 1961, 'General Conclusions: Teleonomic Mechanisms in Cellular Metabolism, Growth, and Differentiation', Cold Spring Harbour Symposia on Quantitative Biology 26, 389-401.
22. Nelson D.L. and Cox M.M.: 2000, Lehninger Principles of Biochemistry, 3rd. ed., Worth, New York.
23. Sarkar S.: 2000, 'Information in Genetics and Developmental Biology: Comments on Maynard Smith', Philosophy of Science 67, 208-213.
24. Seligmann H. and Amzallag G.N.: 2002, 'Chemical Interactions between Amino Acid and RNA: Multiplicity of the Levels of Specificity Explains Origin of the Genetic Code', Naturwissenschaften 89 (12), 542-551.
25. Sterelny K.: 2000, 'The "Genetic Program" Program: A Commentary on Maynard Smith on Information in Biology', Philosophy of Science 67, 195-201.
26. Thieffry D. and Sarkar S.: 1998, 'Forty Years under the Central Dogma', Trends in Biochemical Science 23, 312-316.
27. Woese C.R.: 1967, The Genetic Code: The Molecular Basis for Genetic Expression, Harper and Row, New York.