On the TRAIL of an arthritis cure

Gene Therapy

Volumn 11, Issue 9, 2004, Pages 735-736

  Evans, C H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; AUTOANTIGEN; DOXYCYCLINE; FAS LIGAND; TETRACYCLINE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ADOPTIVE IMMUNOTHERAPY; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; DENDRITIC CELL; EX VIVO STUDY; GENE THERAPY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; NOTE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM;

APOPTOSIS REGULATORY PROTEINS; ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; DENDRITIC CELLS; GENE THERAPY; HUMANS; LIGANDS; MEMBRANE GLYCOPROTEINS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

ADENOVIRIDAE;

EID: 2442698884     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302256     Document Type: Note

References (7)

1. Robbins PD, Evans CH, Chernajovsky Y. Gene therapy for arthritis. Gene Therapy 2003; 10: 902-911.
2. Evans CH et al. Gene therapy for rheumatic diseases. Arthritis Rheum 1999; 42: 1-16.
3. Liu Z et al. CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis. J Clin Invest 2003; 112: 1332-1341.
4. Zhang HG et al. Depletion of collagen II-reactive T cells and blocking of B cell activation prevents collagen II-induced arthritis in DBA/1j mice. J Immunol 2002; 168: 4164-4172.
5. Yao Q et al. Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium. Gene Therapy 2003; 10: 1055-1060.
6. Kim SH et al. Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. J Immunol 2001; 166: 3499-3505.
7. Morita Y et al. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J Clin Invest 2001; 107: 1275-1284.