Potent and metabolically stable agonists for protease-activated receptor-2: Evaluation of activity in multiple assay systems in vitro and in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 309, Issue 3, 2004, Pages 1098-1107

  Kawabata, Atsufumi ^a   Kanke, Toru ^b   Yonezawa, Daiki ^a   Ishiki, Tsuyoshi ^a   Saka, Masako ^b   Kabeya, Mototsugu ^b   Sekiguchi, Fumiko ^a   Kubo, Satoko ^a   Kuroda, Ryotaro ^a   Iwaki, Masahiro ^a   Katsura, Kousaku ^a   Plevin, Robin ^c  

^a KINKI UNIVERSITY   (Japan)

^b Kowa Company Limited   (Japan)

^c UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 FUROYLSERYLLEUCYLISOLEUCYLGLYCYLARGINYLLEUCINAMIDE; 2 FUROYLSERYLLEUCYLISOLEUCYLGLYCYLARGINYLLEUCINE; 2 FUROYLSERYLLEUCYLISOLEUCYLGLYCYLLYSYLVALINAMIDE; 2 FUROYLSERYLLEUCYLISOLEUCYLGLYCYLLYSYLVALINE; AMASTATIN; AMINOPEPTIDASE; CALCIUM; ENZYME INHIBITOR; PEPTIDE DERIVATIVE; PROTEASE ACTIVATED RECEPTOR 2 AGONIST; PROTEINASE ACTIVATED RECEPTOR 2; SERINE; SERYLLEUCYLISOLEUCYLGLYCYLARGINYLLEUCINAMIDE; SERYLLEUCYLISOLEUCYLGLYCYLARGINYLLEUCINE; SERYLLEUCYLISOLEUCYLGLYCYLLYSYLVALINE; SERYLLEUCYLISOLEUCYLGLYCYLVALINAMIDE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONTROLLED STUDY; CYTOSOL; DRUG POTENCY; DRUG RECEPTOR BINDING; ENZYME DEGRADATION; EVALUATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SALIVATION DISORDER; SUPERIOR MESENTERIC ARTERY; VASODILATATION; WILD TYPE;

AMINOPEPTIDASES; ANIMALS; CALCIUM SIGNALING; CELL LINE; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MESENTERIC ARTERIES; MICE; MICE, INBRED C57BL; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PEPTIDES; RATS; RATS, WISTAR; RECEPTOR, PAR-2; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VASOCONSTRICTION; VASODILATION;

EID: 2442697694     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.061010     Document Type: Article

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