VX680, inhibitor of the Aurora kinases, leader of a new family of antitumor agents;L'inhibiteur d'Aurora kinases VX680, chef de file d'une nouvelle famille d'agents antitumoraux

Bulletin du Cancer

Volumn 91, Issue 4, 2004, Pages 300-301

  Lavelle, François ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL; CELL PROLIFERATION; CELL TRANSFORMATION; CHROMOSOME CONDENSATION; HUMAN; PHOSPHORYLATION; SHORT SURVEY; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PIPERAZINES; PROTEIN-SERINE-THREONINE KINASES;

EID: 2442691421     PISSN: 00074551     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (2)

1. Lavelle F. Nouveaux caxanes et dérivés d'épothilones en cours d'études cliniques. Bull Cancer 2002 ; 89 : 343-50.
2. Harrington EA, Bebbington D, Moore J, Rasmussen RK, Ajose-Adeogun A, Nakayama T, et al. VX680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Medecine 2003 ; 10 : 262-7