Correlation between the catalase level in tumor cells and their sensitivity to N-β-Alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD)

Journal of Biochemistry

Volumn 135, Issue 4, 2004, Pages 465-469

  Nishikawa, Takeshi ^a   Nishikawa, Satoshi ^a   Akiyama, Nobuko ^a   Natori, Shunji ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

5 S GAD; Catalase; Hydrogen peroxide; Selective cytotoxicity; Tumor therapy

Indexed keywords

ALANINE DERIVATIVE; CATALASE; COMPLEMENTARY DNA; GLUTATHIONE DERIVATIVE; HYDROGEN PEROXIDE; N BETA ALANYL 5 GLUTATHIONYL 3,4 DIHYDROXYPHENYLALANINE; OXYGEN; PHENYLALANINE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG SENSITIVITY; ENZYME REPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; RNA INTERFERENCE; TUMOR CELL;

BASE SEQUENCE; BLOTTING, WESTERN; CATALASE; CELL LINE, TUMOR; CELL SURVIVAL; DIHYDROXYPHENYLALANINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENETIC VECTORS; GLUTATHIONE; HUMANS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 2442667498     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvh054     Document Type: Article

References (20)

1. Leem, J.Y., Nishimura, C., Kurata, S., Shimada, I., Kobayashi, A., and Natori, S. (1996) Purification and characterization of N-β -alanyl-5-S-glutathionyl-3, 4-dihydroxyphenylalanine, a novel antibacterial substance of Sarcophaga peregrina (flesh fly). J. Biol. Chem. 271, 13573-13577
2. Akiyama, N., Hijikata, M., Kobayashi, A., Yamori, T., Tsuruo, T., and Natori, S. (2000) Anti-tumor effect of N-β -alanyl-5-S-glutathionyldihydroxyphenylalanine (5-S-GAD), a novel antibacterial substance from an insect. Anticancer Res. 20, 357-362
3. Hijikata, M., Matsumoto, H.N., Kobayashi, A., Nifuji, A., Noda, M., and Natori, S. (1999) Induction of apoptosis of monocyte-macrophage lineage cells by 5-S-GAD. FEBS Lett. 457, 405-408
4. Hijikata, M., Kobayashi, A., Leem, J.Y., Fukasawa, H., Uehara, Y., and Natori, S. (1997) Inhibition of protein tyrosine kinase by 5-S-GAD, a novel antibacterial substance from an insect. Biochem. Biophys. Res. Commun. 237, 423-426
5. Leem, J.Y., Park, H.Y., Fukazawa, H., Uehara, Y., and Natori, S. (1998) Inhibitory effects of 5-S-GAD on phosphorylation of V-SRC and BCR-ABL tyrosine kinase. Biol. Pharm. Bull. 21, 784-785
6. 2- in the cytotoxicity of N-β -alanyl-5-S-glutathionyl-3, 4-dihydroxyphenylalanine (5-S-GAD), a novel insect-derived anti-tumor compound. Cancer Sci. 94, 400-404
7. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685
8. Quan, F., Korneluk, R.G., Tropak, M.B., and Gravel, R.A. (1986) Isolation and characterization of the human catalase gene. Nucleic Acids Res. 14, 5321-5335
9. Kozak, M. (1984) Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids Res. 12, 857-872
10. Aebi, H. (1984) Catalase in vitro. Methods Enzymol. 105, 121-126
11. Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498
12. Nathan, C.F. and Cohn, Z.A. (1981) Antitumor effects of hydrogen peroxide in vivo. J. Exp. Med. 154, 1539-1553
13. Fujita, K., Ito, S., Inoue, S., et al. (1980) Selective toxicity of 5-S-cysteinyldopa, a melanin precursor, to tumor cells in vitro and in vivo. Cancer Res. 40, 2543-2546
14. Ito, S., Inoue, S., and Fujita, K. (1983) The mechanism of toxicity of 5-S-cysteinyldopa to tumour cells. Hydrogen peroxide as a mediator of cytotoxicity. Biochem. Pharmacol. 32, 2079-2081
15. Sawa, T., Wu, J., Akaike, T., and Maeda, H. (2000) Tumor-targeting chemotherapy by a xanthine oxidase-polymer conjugate that generates oxygen-free radicals in tumor tissue. Cancer Res. 60, 666-671
16. Fang, J., Sawa, T., Akaike, T., and Maeda, H. (2002) Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide. Cancer Res. 62, 3138-3143
17. Isuzugawa, K., Inoue, M., and Ogihara, Y. (2001) Catalase contents in cells determine sensitivity to the apoptosis inducer gallic acid. Biol. Pharm. Bull. 24, 1022-1026
18. Kawada, M., Ohno, Y., Ri, Y., et al. (2001) Anti-tumor effect of gallic acid on LL-2 lung cancer cells transplanted in mice. Anti-cancer Drugs 12, 847-852
19. Oberley, T.D. and Oberley, L.W. (1997) Antioxidant enzyme levels in cancer. Histol. Histopathol. 12, 525-535
20. Leirdal, M. and Sioud, M. (2002) Gene silencing in mammalian cells by preformed small RNA duplexes. Biochem. Biophys. Res. Commun. 295, 744-748