Effects of toltrazuril and ponazuril on the fine structure and multiplication of tachyzoites of the NC-1 strain of Neospora caninum (a synonym of Hammondia heydorni) in cell cultures

Parasitology Research

Volumn 92, Issue 6, 2004, Pages 453-458

  Darius, Anne Kathrin ^a   Mehlhorn, Heinz ^a   Heydorn, Alfred Otto ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COCCIDIOSTATIC AGENT; PONAZURIL; TOLTRAZURIL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; APICOPLAST; ARTICLE; CELL DESTRUCTION; CELL ORGANELLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG EFFICACY; ELECTRON MICROSCOPY; INCUBATION TIME; LIVER MITOCHONDRION; MICROSCOPY; NEOSPORA CANINUM; NONHUMAN; PARASITE CULTIVATION; PARASITE DEVELOPMENT; PARASITE SURVIVAL; PRIORITY JOURNAL; PROTOZOAL INFECTION; RHESUS MONKEY;

ANIMALS; CELL LINE; COCCIDIOSTATS; CULTURE MEDIA; MACACA MULATTA; MICROSCOPY; MICROSCOPY, ELECTRON; MITOCHONDRIA; NEOSPORA; ORGANELLES; TRIAZINES;

HAMMONDIA; HAMMONDIA HEYDORNI; MACACA MULATTA; NEOSPORA CANINUM;

EID: 2442661358     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-003-1063-7     Document Type: Article

References (17)

1. Dubey JP (1977) Toxoplasma, Hammondia, Besnoitia, Sarcocystis and other tissue forming coccidia of man and animals. In: Kreier JP (ed) Parasitic protozoa, vol III. Academic Press, New York
2. Gottstein B, Eperon S, Dai WJ, Cannes A, Hemphill A, Greif G (2001) Efficacy of toltrazuril and ponazuril against experimental Neospora caninum infection in mice. Parasitol Res 87:43-48
3. Haberkorn A (1996) Chemotherapy of human and animal coccidioses: state and perspectives. Parasitol Res 82:193-199
4. Hackstein JHP, Mackenstedt U, Mehlhorn H, Meijeringk JPP, Schubert H, Leunissen JAM (1995) Parasitic apicomplexans harbor a chlorophyll a-D 1 complex, the potential target for therapeutic triazines. Parasitol Res 81:207-216
5. Hammond DJ, Burchell JR, Pudney M (1985) Inhibition of pyrimidine biosynthesis de-novo in Plasmodium falciparum by 2-(4-t-butyl-cyclohexyl)-3- hydroxy-1,4-naphtoquinone in-vitro. Mol Biochem Parasitol 14:97-109
6. Harder A (2001) Chemotherapy. In: Mehlhorn H (ed) Encyclopedic references of parasitology. Springer, Berlin Heidelberg New York
7. Harder H, Haberkorn A (1989) Possible mode of action of toltrazuril: studies on two Eimeria species and Ascaris suum enzymes. Parasitol Res 76:8-12
8. Heydorn AO (1973) Studies on the life cycle of the small race of Isospora bigemina of the dog. I. Cattle and dog as possible intermediary hosts. Berl Münch Tierärztl Wochenschr 86:323-329
9. Heydorn AO, Mehlhorn H (2002) Neospora caninum is an invalid species name: an evaluation of facts and statements. Parasitol Res 88:175-184
10. Lindsay DS, Rippey NS, Cole RA, Parsons LC, Dubey JP, Tidwell RR, Blagburn BL (1994) Examination of the activities of 43 chemotherapeutic agents against Neospora caninum tachyzoites in cultured cells. Am J Vet Res 55:976-981
11. Mehlhorn H, Heydorn AO (2000) Neospora caninum: is it really different from Hammondia heydorni or is it a strain of Toxoplasma gondii. An opinion. Parasitol Res 86:169-178
12. Mehlhorn H, Heydorn AO (2003) Electron microscopic study on in-vitro cultured Hammondia heydorni (Berlin-1996) - tachyzoites after passages through dogs, mice, rats, guinea pigs and jirds. Parasitol Res 90:512-520
13. Mehlhorn H, Ortmann-Falkenstein G, Haberkorn A (1984) The effects of sym. triazinones on developmental stages of Eimeria tenella, E. maxima and E. acervulina: a light and electron microscopical study. Parasitol Res 70:173-182
14. Müller N, Sager H, Hemphill A, Mehlhorn H, Heydorn AO (2001) Comparative molecular investigation of NC5-PCR- amplicons from Neospora caninum NC-1 and Hammondia heydorni-Berlin 1996. Parasitol Res 87:883-885
15. Ricketts AP, Pfefferkorn ER (1993) Toxoplasma gondii: susceptibility and development of resistance to anticoccidial drugs in vitro. Antimicrob Chemother 23:58-63
16. Schares G, Heydorn AO, Cüppers A, Conrath FJ, Mehlhorn H (2001a) Hammondia heydorni-like oocysts shed by a naturally infected dog and Neospora caninum NC-1 cannot be distinguished. Parasitol Res 87:808-816
17. Schares G, Heydorn AO, Cüppers A, Conrath FJ, Mehlhorn H (2001b) Cyclic transmission of Neospora caninum: serological findings in oocyst shedding dogs. Parasitol Res 87:873-877