Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of dihydroneopterin aldolases

Plant Physiology

Volumn 135, Issue 1, 2004, Pages 103-111

  Goyer, Aymeric ^a   Illarionova, Victoria ^b   Roje, Sanja ^a   Fischer, Markus ^b   Bacher, Adelbert ^b   Hanson, Andrew D ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; CLONING; DNA; ENZYMES; GENES;

EPIMERIZATION; GENE ENCODING;

PLANTS (BOTANY);

ARABIDOPSIS; BACTERIA (MICROORGANISMS); EMBRYOPHYTA; ESCHERICHIA COLI; LYCOPERSICON; LYCOPERSICON ESCULENTUM;

EID: 2442645536     PISSN: 00320889     EISSN: None     Source Type: Journal    
DOI: 10.1104/pp.103.038430     Document Type: Article

References (44)

1. Basset GJC, Quinlivan EP, Ravanel S, Rébeillé F, Nichols BP, Shinozaki K, Seki M, Adams-Phillips LC, Giovannoni JJ, Gregory JF III (2004) Folate synthesis in plants: the p-aminobenzoate branch is initiated by a bifunctional PabA-PabB protein that is targeted to plastids. Proc Natl Acad Sci USA 101: 1496-1501
2. Basset G, Quinlivan EP, Ziemak MJ, Diaz De La Garza R, Fischer M, Schiffmann S, Bacher A, Gregory JF III, Hanson AD (2002) Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I. Proc Natl Acad Sci USA 99: 12489-12494
3. Bermingham A, Derrick JP (2002) The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery. Bioessays 24: 637-648
4. Bouis HE (2002) Plant breeding: a new tool for fighting micronutrient malnutrition. J Nutr 132: 491S-494S
5. Bullock WO, Fernandez JM, Short JM (1987) XL1-Blue: a high efficiency plasmid transforming recA Escherichia coli strain with β-galactosidase selection. BioTechniques 5: 376-379
6. Chandok MR, Ytterberg AJ, van Wijk KJ, Klessig DF (2003) The pathogen-inducible nitric oxide synthase (iNOS) in plants is a variant of the P protein of the glycine decarboxylase complex. Cell 113: 469-482
7. Cossins EA, Chen L (1997) Folates and one-carbon metabolism in plants and fungi. Phytochemistry 45: 437-452
8. de Bree A, van Dusseldorp M, Brouwer IA, van het Hof KH, Steegers-Theunissen RPM (1997) Folate intake in Europe: recommended, actual and desired intake. Eur J Clin Nutr 51: 643-660
9. De Saizieu A, Vankan P, van Loon AP (1995) Enzymic characterization of Bacillus subtilis GTP cyclohydrolase I. Evidence for a chemical dephosphorylation of dihydroneopterin triphosphate. Biochem J 306: 371-377
10. Emanuelsson O, von Heijne G (2001) Prediction of organellar targeting signals. Biochim Biophys Acta 1541: 114-119
11. Forrest HS, Van Baalen C (1970) Microbiology of unconjugated pteridines. Annu Rev Microbiol 24: 91-108
12. Gibeaut DM, Hulett J, Cramer GR, Seemann JR (1997) Maximal biomass of Arabidopsis thaliana using a simple, low-maintenance hydroponic method and favorable environmental conditions. Plant Physiol 115: 317-319
13. Green JC, Nichols BP, Matthews RG (1996) Folate biosynthesis, reduction, and polyglutamylation. In FC Neidhardt, ed, Escherichia coli and Salmonella: Cellular and Molecular Biology, Vol 1. ASM Press, Washington, DC, pp 665-673
14. Guroff G, Rhoads CA (1969) Phenylalanine hydroxylation by Pseudomonas species (ATCC 11299a). Nature of the cofactor. J Biol Chem 244: 142-146
15. Hamilton AJ, Lycett GW, Grierson D (1990) Antisense gene that inhibits synthesis of the hormone ethylene in transgenic plants. Nature 346: 284-287
16. Hanson AD, Gregory JF III (2002) Synthesis and turnover of folates in plants. Curr Opin Plant Biol 5: 244-249
17. Haußmann C, Rohdich F, Schmidt E, Bacher A, Richter G (1998) Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase. J Biol Chem 273: 17418-17424
18. Hennig M, D'Arcy A, Hampele IC, Page MG, Oefner C, Dale GE (1998) Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus. Nat Struct Biol 5: 357-362
19. Ikemoto K, Sugimoto T, Murata S, Tazawa M, Nomura T, Ichinose H, Nagatsu T (2002) (6R)-5,6,7,8-tetrahydro-L-monapterin from Escherichia coli, a novel natural unconjugated tetrahydropterin. Biol Chem 383: 325-330
20. Iwai K, Bunno M, Kobashi M, Suzuki T (1976) Isolation and characterization of 6-hydroxymethylpterin as the Crithidia growth-promoting factor from spinach chloroplasts. Biochim Biophys Acta 444: 618-622
21. Kang D, Kim S, Yim J (1998) Biosynthetic enzymes of tetrahydrolimipterin from green sulfur bacterium Chlorobium limicola. Pteridines 9: 69-84
22. Kobayashi K, Forrest HS, el-Emary M (1967) Isolation of 6-hydroxymethyllumazine (phosphodoxin?) and two other lumazine derivatives from spinach, and their synthesis. Arch Biochem Biophys 121: 220-223
23. Kohashi M (1980) Isolation of six unconjugated pteridines from soybean (Glycine max L. Tsurunoko) seeds. J Biochem (Tokyo) 87: 1581-1586
24. Kohashi M, Tomita K, Iwai K (1980) Analysis of unconjugated pterins in food resources and human urine. Agric Biol Chem 44: 2089-2094
25. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685
26. Lee SW, Lee HW, Chung HJ, Kim YA, Kim YJ, Hahn Y, Chung JH, Park YS (1999) Identification of the genes encoding enzymes involved in the early biosynthetic pathway of pteridines in Synechocystis sp. PCC 6803. FEMS Microbiol Lett 176: 169-176
27. Li Y, Baldauf S, Lim EK, Bowles DJ (2001) Phylogenetic analysis of the UDP-glycosyltransferase multigene family of Arabidopsis thaliana. J Biol Chem 276: 4338-4343
28. Lim EK, Baldauf S, Li Y, Elias L, Worrall D, Spencer SP, Jackson RG, Taguchi G, Ross J, Bowles DJ (2003) Evolution of substrate recognition across a multigene family of glycosyltransferases in Arabidopsis. Glycobiology 3: 139-145
29. Lopez P, Lacks SA (1993) A bifunctional protein in the folate biosynthetic pathway of Streptococcus pneumoniae with dihydroneopterin aldolase and hydroxymethyldihydropterin pyrophosphokinase activities. J Bacteriol 175: 2214-2220
30. Mathis JB, Brown GM (1980) Dihydroneopterin aldolase from Escherichia coli. Methods Enzymol 66: 556-560
31. Mendel RR, Hänsch R (2002) Molybdoenzymes and molybdenum cofactor in plants. J Exp Bot 53: 1689-1698
32. Ravanel S, Cherest H, Jabrin S, Grunwald D, Surdin-Kerjan Y, Douce R, Rébeillé F (2001). Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana. Proc Natl Acad Sci USA 98: 15360-15365
33. Rébeillé F, Douce R (1999) Folate synthesis and compartmentation in higher plants. In NJ Kruger, SA Hill, RG Ratcliffe, eds, Regulation of Primary Metabolic Pathways in Plants. Kluwer, Dordrecht, The Netherlands, pp 53-99
34. Scott J, Rébeillé F, Fletcher J (2000) Folic acid and folates: the feasibility for nutritional enhancement in plant foods. J Sci Food Agric 80: 795-824
35. Soltis DE, Soltis PS (2003) The role of phylogenetics in comparative genetics. Plant Physiol 132: 1790-1800
36. Soltis DE, Soltis PS, Chase MW, Mort ME, Albach DC, Zanis M, Savolainen V, Hahn WH, Hoot SB, Fay MF, et al. (2000) Angiosperm phylogeny inferred from a combined data set of 18S rDNA, rbcL and atpB sequences. Bot J Linn Soc 133: 381-461
37. Stüber D, Matile H, Garotta G (1990) System for high-level production in Escherichia coli and rapid purification of recombinant proteins: application to epitope mapping, preparation of antibodies and structure-function analysis. In I Lefkovits, P Pernis, eds, Immunological Methods, Vol 4. Academic Press, New York, pp 121-152
38. Sugiura K, Goto M (1966) Isolation and identification of 6-hydroxymethyllumazine from spinach. J Biochem (Tokyo) 60: 335-337
39. Suzuki Y, Brown GM (1974) The biosynthesis of folic acid. XII. Purification and properties of dihydroneopterin triphosphate pyrophosphohydrolase. J Biol Chem 249: 2405-2410
40. Thöny B, Auerbach G, Blau N (2000) Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem J 347: 1-16
41. Volpe F, Ballantine SP, Delves CJ (1993) The multifunctional folic acid synthesis fas gene of Pneumocystis carinii encodes dihydroneopterin aldolase, hydroxymethyldihydropterin pyrophosphokinase and dihydropteroate synthase. Eur J Biochem 216: 449-458
42. Yamamoto K, Kobayashi N, Yoshitama K, Teramoto S, Komamine A (2001) Isolation and purification of tyrosine hydroxylase from callus cultures of Portulaca grandiflora. Plant Cell Physiol 42: 969-975
43. Yoshida T, Akino M (1980) Occurrence of unconjugated pterins in the higher plant, Stizolobium hassjoo. Experientia 36: 639-640
44. Ziegler I (2003) The pteridine pathway in zebrafish: regulation and specification during the determination of neural crest cell-fate. Pigment Cell Res 16: 172-182