Gentamicin release from two-solution and powder-liquid poly(methyl methacrylate)-based bone cements by using novel pH method

Journal of Biomedical Materials Research - Part A

Volumn 69, Issue 3, 2004, Pages 577-583

  Merkhan, Imad K ^a   Hasenwinkel, Julie M ^a   Gilbert, Jeremy L ^a  

^a SYRACUSE UNIVERSITY   (United States)

Author keywords

Bone cement; Gentamicin sulfate; pH; Poly(methyl methacrylate)

Indexed keywords

DIFFUSION; MIXING; PH EFFECTS; PHOSPHATES; POLYMETHYL METHACRYLATES; SOLUTIONS;

GENTAMICIN; PHOSPHATE BUFFERED SALINE (PSB);

BONE CEMENT;

BONE CEMENT; GENTAMICIN; PALACOS; POLY(METHYL METHACRYLATE); SODIUM CHLORIDE;

AQUEOUS SOLUTION; ARTICLE; DRUG RELEASE; ELUTION; IN VITRO STUDY; KINETICS; PH; PH MEASUREMENT;

EID: 2442640308     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.30033     Document Type: Article

References (19)

1. Shah SM, Gul R, Chan FC, O'Rourke P. Current trends for infection prevention in total hip arthroplasty - a survey in Republic of Ireland. Ir Med J 2003;96:91.
2. Charnley J, Eftekhar N. Postoperative infection in total prosthetic replacement arthroplasty of the hip-joint. With special reference to the bacterial content of the air of the operating room. Br J Surg 1969;56:641-649.
3. Buchholz HW, Elson RA, Heinert K. Antibiotic loaded acrylic cement: current concepts. Clin Orthop 1984;190:96-108.
4. van de Belt H, Uges DR, Schenk W, Van Horn JR, Van der Mei HC, Busscher HJ. Surface roughness, porosity, and wettability of gentamicin-loaded bone cements and their antibiotic release. Biomaterials 2000;21:1981-1997.
5. Torrado S, Frutos P, Frutos G. Gentamicin bone cements: characterisation and release (in vitro and in vivo assays). Int J Pharm 2001;217:57-69.
6. Ara J, Gans Z, Sweeney R, Wolf B. Dot-ELISA for the rapid detection of gentamicin in milk. J Clin Lab Anal 1995;9:320-324.
7. Miglioli PA, Pea F, Mazzo M, Berti T, Lanzafame P. Possible influence of assay methods in studies of the pharmacokinetics of antibiotics. J Chemother 1993;5:27-31.
8. Bunetel L, Segui A, Cormier M, Percheron E, Langlais F. Release of gentamicin from acrylic bone cement. Clin Pharmacokinet 1989;17:291-297.
9. Bayston R, Milner RD. The sustained release of antimicrobial drugs from bone cement. An appraisal of laboratory investigations and their significance. J Bone Joint Surg Br 1982;64:460-464.
10. Beeching NJ, Thomas MG, Roberts S, Lang SD. Comparative in-vitro activity of antibiotics incorporated in acrylic bone cement. J Antimicrob Chemother 1986;17:173-184.
11. Frutos P, Torrado S, Perez-Lorenzo ME, Frutos G. A validated quantitative colorimetric assay for gentamicin. J Pharm Biomed Anal 2000;21:1149-1159.
12. Ayad MM, Shalaby AA, Abdellatef HE, Elsaid HM. Spectrophotometric and atomic absorption spectrometric determination of certain cephalosporins. J Pharm Biomed Anal 1999;18:975-983.
13. del Real RP, Padilla S, Vallet-Regi M. Gentamicin release from hydroxyapatite/poly(ethyl methacrylate)/poly(methyl methacrylate) composites. J Biomed Mater Res 2000;52:1-7.
14. Frutos Cabanillas P, Diez Pena E, Barrales-Rienda JM, Frutos G. Validation and in vitro characterization of antibiotic-loaded bone cement release. Int J Pharm 2000;209:15-26.
15. Kuhn K-D. Bone cements, up-to-date comparison of physical and chemical properties of commercial materials. Springer-Verlag: Berlin; 2000.
16. Lewis G, Nyman JS, Trieu HH. Effect of mixing method on selected properties of acrylic bone cement. J Biomed Mater Res 1997;38:221-228.
17. Wang JS, Franzen H, Jonsson E, Lidgren L. Porosity of bone cement reduced by mixing and collecting under vacuum. Acta Orthop Scand 1993;64:143-146.
18. Wang JS, Toksvig-Larsen S, Muller-Wille P, Franzen H. Is there any difference between vacuum mixing systems in reducing bone cement porosity? J Biomed Mater Res 1996;33:115-119.
19. He Y, Trotignon JP, Loty B, Tcharkhtchi A, Verdu J. Effect of antibiotics on the properties of poly(methylmethacrylate)-based bone cement. J Biomed Mater Res 2002;63:800-806.