Comparative disposition of [14C]ertapenem, a novel carbapenem antibiotic, in rat, monkey and man

Xenobiotica

Volumn 34, Issue 4, 2004, Pages 379-389

  Wong, B K ^a   Xu, X ^a   Yu, S ^a   Lin, J H ^a   Singh, R ^a   Sahly, Y ^a   Mistry, G ^a   Holland, S ^a   Waldman, S ^b   Musson, D ^a   Majumdar, A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AMINOACYLASE; ANTIBIOTIC AGENT; BETA LACTAM; CARBAPENEM DERIVATIVE; CARBON 14; CILASTATIN; DRUG METABOLITE; ERTAPENEM; CARBON; LACTAM; RADIOPHARMACEUTICAL AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DRUG ELIMINATION; DRUG EXCRETION; DRUG HYDROLYSIS; DRUG METABOLISM; FECES ANALYSIS; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN VERSUS ANIMAL COMPARISON; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; KIDNEY; KIDNEY HOMOGENATE; LUNG; LUNG HOMOGENATE; MALE; NONHUMAN; NORMAL HUMAN; RADIOACTIVITY; RAT; RHESUS MONKEY; RING OPENING; SINGLE DRUG DOSE; URINALYSIS; URINARY EXCRETION; ANIMAL; ANTIBODY SPECIFICITY; BLOOD; CHEMISTRY; CLINICAL TRIAL; FECES; ISOTOPE DILUTION ASSAY; MACACA; METABOLIC CLEARANCE RATE; MIDDLE AGED; SPECIES DIFFERENCE; TISSUE DISTRIBUTION; URINE; VALIDATION STUDY;

ANIMALIA; MACACA MULATTA;

ADULT; ANIMALS; BETA-LACTAMS; CARBAPENEMS; CARBON RADIOISOTOPES; FECES; FEMALE; HUMANS; LACTAMS; MACACA MULATTA; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; ORGAN SPECIFICITY; RADIOISOTOPE DILUTION TECHNIQUE; RADIOPHARMACEUTICALS; RATS; SPECIES SPECIFICITY; TISSUE DISTRIBUTION;

EID: 2442631499     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250410001670643     Document Type: Article

References (19)

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