The discovery of factor V: A tricky clotting factor

Journal of Thrombosis and Haemostasis

Volumn 1, Issue 2, 2003, Pages 206-213

  Stormorken, H ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

Coagulation; Discovery; Factor V; Platelets; Polymorphisms

Indexed keywords

BLOOD CLOTTING FACTOR 5;

ART; ARTICLE; BIOLOGICAL MODEL; BLOOD CLOTTING; BLOOD CLOTTING FACTOR 5 DEFICIENCY; FEMALE; GENETICS; HISTORY; HUMAN; NORWAY; PHYSIOLOGY;

BLOOD COAGULATION; FACTOR V; FACTOR V DEFICIENCY; FEMALE; HISTORY, 20TH CENTURY; HUMANS; MODELS, BIOLOGICAL; NORWAY; PORTRAITS;

EID: 0141673371     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1046/j.1538-7836.2003.00043.x     Document Type: Review

References (27)

1. Arthus M, Pagès C. Nouvelle theorie chimique de la coagulation du sang. Arch Physiol Norm Pathol 1890; 5: 739-46.
2. Pekelharing CA. Untersuchung über das Fibrinferment. Internat Beitr Zschr Wissensch Med (Festschr Rudolf Virchow), 1891; 1: 433-56.
3. Schmidt A. Zur Blutlehre, Vogel, Leipzig, 1892.
4. Hammarsten O. Weitere Beiträge zur Kenntnis der Fibrinbildung. Zeitschr Physiol Chem 1899; 28: 98-114.
5. Morawitz P. Die Chemie der Blutgerinnung. Ergebn Physiol 1905; 4: 307-422.
6. Owren PA. The coagulation of blood: investigations on a new clotting factor. JR Gundersen, Oslo, 1947. Dissertation 327 pp. (Also published as Suppl. 194 to Acta Med Scand 1947).
7. Owren PA. Parahaemophilia. Haemorrhagic diathesis due to absence of a previously unknown clotting factor. Lancet 1947; 1: 446-51.
8. Owren PA. The fifth coagulation factor (factor V). Preparation and properties. Biochem J 1948; 43: 136-9.
9. Quick AJ. On the constitution of prothrombin. Am J Physiol 1943/44; 140: 212-20.
10. Fantl P, Nance M. Acceleration of thrombin formation by a plasma component. Nature 1946; 158: 708-9.
11. Ware AG, Guest MM, Seegers WH. Plasma accelerator factor and purified prothrombin activation. Science 1947; 106: 41-2.
12. Owren PA. Congenital hemolytic jaundice. The pathogenesis of the 'hemolytic crisis'. Blood 1948; 3: 231-48.
13. Seegers WH. Prothrombin. Monograph. Harward University Press, Harvard, 1962.
14. Vroman L. Disc. In: Blood Clotting Enzymology, eds. W H Seegers. Academic Press, New York, 1967: 294.
15. Fisher A. Blutgerinnung als unbegrenzt Übertragbare Kettenreaktion. Biochem Ztschr 1935; 279: 108-14.
16. Owren PA. Proceedings of the International Congress of the Society of Hematology, Cambridge 1950, Grune & Stratton, New York, 1951: 378.
17. Owren PA. The present state of the converting and accelerator factors in prothrombin conversion. In: Koller TH, Merz WR, eds. Thrombosis and Embolism. I International Conference, Basle 1954, Benno Schwabe & Co, Basle, 1955: 65-75.
18. Macfarlane RG. An enzyme cascade in the blood clotting mechanism, and the function as a biochemical amplifier. Nature (Lond) 1964; 202: 498-9.
19. Davie EW, Ratnoff OD. Waterfall sequence for intrinsic blood clotting. Science 1964; 145: 1310-2.
20. Rapaport SI, Shiffman S, Patch MJ, Ames SB. The importance of activation of antihemophilic globulin and proaccelerin by traces of thrombin in the generation of intrinsic prothrombinase activity. Blood 1963; 21: 221-36.
21. Osterud B, Rapaport SI. Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation. Proc Natl Acad Sci USA 1977; 74: 5260-4.
22. Josso F, Prou-Wartelle O. Interaction of tissue factor and F VII at the earliest phase of coagulation. Thromb Haemost Suppl. 1965; 17: 35-44.
23. Tracy PB, Giles AR, Mann KG, Eide LL, Hoogendoorn H, Rivard GE. (Quebec): a bleeding diathesis associated with a qualitative platelet factor V deficiency. Clin Invest 1984; 74: 1221-8.
24. Weiss HJ, Lages B, Zheng S, Hayward CP. Platelet factor V New York: a defect in factor V distinct from that in factor V Quebec resulting in impaired prothrombinase generation. Am J Hemat 2001; 66: 130-9.
25. Dahlbäck B, Hildebrand B. Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V. Proc Natl Acad Sci USA 1993; 91: 1396-400.
26. Bertina R.M, Koeleman B.P, Koster T, Rosendaal F.R, Dirven R.J, de Ronde H, van der Velden P.A, Reitsma P.H. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
27. Stormorken H. Paul A. Owren and the Golden Era of Haemostasis. Monograph 2003.