Well-differentiated Liposarcoma Associated with Benign Lipoma

Anticancer Research

Volumn 24, Issue 2 C, 2004, Pages 1039-1044

  Hatano, Hiroshi ^a   Morita, Tetsuro ^a   Ogose, Akira ^b   Hotta, Tetsuo ^b   Kobayashi, Hiroto ^a   Honma, Keiichi ^a  

^a NIIGATA CANCER CENTER HOSPITAL   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

Lipoma; Liposarcoma

Indexed keywords

CYCLIN DEPENDENT KINASE 4; KI 67 ANTIGEN; PROTEIN MDM2; PROTEIN P53;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CLINICAL FEATURE; DISEASE ASSOCIATION; FEMALE; GENETIC ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIPOMA; LIPOSARCOMA; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WELL DIFFERENTIATED LIPOSARCOMA;

AGED; AGED, 80 AND OVER; CELL DIFFERENTIATION; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LIPOMA; LIPOSARCOMA; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 2442610940     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Weiss SW and Goldblum JR: Liposarcoma. In: Weiss SW, Goldblum JR eds. Enzinger and Weiss's Soft Tissue Tumors. St. Louise: Mosby, 641-693, 2001.
2. Dei Tos AP and Pedeutour F: Atypical lipomatous tumor/Well differentiated liposarcoma. In: Fletcher CDM, Unni KK, Mertens F eds. Pathology & Genetics. Tumors of Soft Tissue and Bone. Lyon: IARC Press, 35-37, 2002.
3. Barkhof F, Melkert P, Meyer S and Blomjous CE: Derangement of adipose tissue: a case report of multicentric retroperitoneal liposarcomas, retroperitoneal lipomatosis and multiple subcutaneous lipomas. Eur J Surg Oncol 17: 547-50, 1991.
4. Amato G, Martella A, Ferraraccio F, Di Martino N, Maffettone V, Landolfi V, FeiL and Del Genio A: Well differentiated "lipoma-like" liposarcoma of the sigmoid mesocolon and multiple lipomatosis of the rectosigmoid colon. Report of a case. Hepatogastroenterology 45: 2151-6, 1998.
5. Matsumoto K, Hukuda S, Ishizawa M, Egawa M and Okabe H: Liposarcoma associated with multiple intramuscular lipomas. A case report. Clin Orthop 373: 202-7, 2000.
6. Boltze C, Schneider-Stock R, Jager V and Roessner A: Distinction between lipoma and liposarcoma by MDM2 alterations: a case report of simultaneously occurring tumors and review of the literature. Pathol Res Pract 197: 563-8, 2001.
7. Yang YJ, Damron TA, Cohen H and Hojnowski L: Distinction of well-differentiated liposarcoma from lipoma in two patients with multiple well-differentiated fatty masses. Skeletal Radiol 30: 584-9, 2001.
8. Mentzel T: Biological continuum of benign, atypical, and malignant mesenchymal neoplasms -does it exist? J Pathol 190: 523-5, 2000.
9. Fletcher CD, Akerman M, Dal Cin P, de Wever I, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Sciot R, Tallini G, van den Berghe H, van de Ven W, Vanni R and Willen H: Correlation between clinicopathological features and karyotype in lipomatous tumors. A report of 178 cases from the Chromosomes and Morphology (CHAMP) Collaborative Study Group. Am J Pathol 148: 623-30, 1996.
10. Willen H, Akerman M, Dal Cin P, De Wever I, Fletcher CD, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Sciot R, Tallini G, Van den Berghe H and Vanni R: Comparison of chromosomal patterns with clinical features in 165 lipomas: a report of the CHAMP study group. Cancer Genet Cytogenet 102: 46-9, 1998.
11. Dal Cin P, Kools P, Sciot R, De Wever I, Van Damme B, Van de Ven W and Van den Berghe H: Cytogenetic and fluorescence in situ hybridization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors. Cancer Genet Cytogenet 68: 85-90, 1993.
12. Pedeutour F, Forus A, Coindre JM, Berner JM, Nicolo G, Michiels JF, Terrier P, Ranchere-Vince D, Collin F, Myklebost O and Turc-Carel C: Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors. Genes Chromosomes Cancer 24: 30-41, 1999.
13. Pilotti S, Della Torre G, Lavarino C, Sozzi G, Minoletti F, Vergani B, Azzarelli A, Rilke F and Pierotti MA: Molecular abnormalities in liposarcoma: role of MDM2 and CDK4-containing amplicons at 12q13-22. J Pathol 185: 188-90, 1998.
14. Khatib ZA, Matsushime H, Valentine M, Shapiro DN, Sherr CJ and Look AT: Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas: Cancer Res 53: 5535-41, 1993.
15. Sherr CJ: Cancer cell cycles. Science 274: 1672-7, 1996.
16. Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW and Vogelstein B: Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature 362: 857-60, 1993.
17. Leach FS, Tokino T, Meltzer P, Burrell M, Oliner JD, Smith S, Hill DE, Sidransky D, Kinzler KW and Vogelstein B: p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res 53: 2231-4, 1993.
18. Dei Tos AP, Doglioni C, Piccinin S, Sciot R, Furlanetto A, Boiocchi M, Dal Cin P, Maestro R, Fletcher CD and Tallini G: Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours. J Pathol 190: 531-6, 2000.
19. Pilotti S, Della Torre G, Mezzelani A, Tamborini E, Azzarelli A, Sozzi G and Pierotti MA: The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. Br J Cancer 82: 1271-5, 2000.
20. Heslin MJ, Cordon-Cardo C, Lewis JJ, Woodruff JM and Brennan MF: Ki-67 detected by MIB-1 predicts distant metastasis and tumor mortality in primary, high grade extremity soft tissue sarcoma. Cancer 83: 490-7, 1998.
21. Hasegawa T, Yamamoto S, Yokoyama R, Umeda T, Matsuno Y and Hirohashi S: Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk. Cancer 95: 843-51, 2002.
22. Cordon-Cardo C, Latres E, Drobnjak M, Oliva MR, Pollack D, Woodruff JM, Marechal V, Chen J, Brennan MF and Levine AJ: Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 54: 794-9, 1994.
23. Lovell-Badge R: Developmental genetics: Living with bad architecture. Nature 376: 725-6, 1995.
24. Ashar HR, Fejzo MS, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC and Chada K: Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82: 57-65, 1995.
25. Broberg K, Zhang M, Strombeck B, Isaksson M, Nilsson M, Mertens F, Mandahl N and Panagopoulos I: Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15. Int J Oncol 21: 321-6, 2002.
26. Storlazzi CT, Mertens F, Domanski H, Fletcher CD, Wiegant J and Mandahl N: Ring chromosomes and low-grade gene amplification in an atypical lipomatous tumor with minimal nuclear atypia. Int J Oncol 23: 67-71, 2003.