Enhanced circulating half-life and hematopoietic properties of a human granulocyte colony-stimulating factor/immunoglobulin fusion protein

Experimental Hematology

Volumn 32, Issue 5, 2004, Pages 441-449

  Cox, George N ^a   Smith, Darin J ^a   Carlson, Sharon J ^a   Bendele, Alison M ^b   Chlipala, Elizabeth A ^b   Doherty, Daniel H ^a  

^a Bolder BioTechnology Inc   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; DISULFIDE; GRANULOCYTE COLONY STIMULATING FACTOR; HYBRID PROTEIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G4; PROTEIN A;

AFFINITY CHROMATOGRAPHY; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; CELL STIMULATION; CELL STRAIN COS1; CHIMERA; CIRCULATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CLEARANCE; DRUG HALF LIFE; GENE CONSTRUCT; GENETIC CODE; GENETIC TRANSFECTION; GRANULOPOIESIS; HEMATOPOIESIS; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; MEASUREMENT; NEUTROPHIL; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PURIFICATION; PROTEIN SECRETION; RAT;

ANIMALS; BLOOD CELL COUNT; BONE MARROW EXAMINATION; COS CELLS; GRANULOCYTE COLONY-STIMULATING FACTOR; HALF-LIFE; HEMATOPOIESIS; HUMANS; IMMUNOGLOBULIN G; LEUKOCYTES; MALE; NEUTROPHILS; PHARMACOKINETICS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 2442575912     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2004.01.012     Document Type: Article

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