Transcriptional Blocks Limit Adenoviral Replication in Primary Ovarian Tumor

Clinical Cancer Research

Volumn 10, Issue 9, 2004, Pages 3189-3194

  Preuss, Meredith A ^a   Lam, John T ^a   Wang, Minghui ^a   Leath III, Charles A ^b   Kataram, Manjula ^a   Mahasreshti, Parameshwar J ^a,b   Alvarez, Ronald D ^b   Curiel, David T ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

E1A PROTEIN; E1B PROTEIN; VIRUS RNA;

ADENOVIRUS 5; ARTICLE; CANCER THERAPY; CONDITIONALLY REPLICATING ADENOVIRUS THERAPY; CONTROLLED STUDY; CYTOLYSIS; EMBRYO; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; ONCOLYSIS; OVARY TUMOR; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; VIRION; VIRUS INFECTION; VIRUS PARTICLE; VIRUS REPLICATION; WESTERN BLOTTING;

ADENOVIRIDAE; ADENOVIRUS E1A PROTEINS; ADENOVIRUS E1B PROTEINS; BLOTTING, WESTERN; FEMALE; HUMANS; OVARIAN NEOPLASMS; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

EID: 2442545368     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-03-0802     Document Type: Article

References (22)

1. Kirn D. Oncolytic virotherapy for cancer with the adenovirus d11520 (Onyx-015): results of Phase I and II trials. Expert Opin Biol Ther 2001;1:525-38.
2. Nemunaitis J, Khuri F, Ganly I, et al. Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer. J Clin Oncol 2001;19:289-98.
3. Dmitriev I, Krasnykh V, Miller CR, et al. An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J Virol 1998;72:9706-13.
4. Vanderkwaak TJ, Wang M, Gomez-Navarro J, et al. An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches. Gynecol Oncol 1999;74:227-34.
5. Reynolds PN, Curiel DT. New generation adenoviral vectors improve gene transfer by coxsackie and adenoviral receptor-independent cell entry. Kidney Int 2002;61(Suppl 1):24-31.
6. Krasnykh V, Dmitriev I, Navarro JG, et al. Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity. Cancer Res 2000;60:6784-7.
7. Wu H, Seki T, Dmitriev I, et al. Double modification of adenovirus fiber with RGD and polylysine motifs improves coxsackievirus-adenovirus receptor-independent gene transfer efficiency. Hum Gene Ther 2002;13:1647-53.
8. Hemminki A, Belousova N, Zinn KR, et al. An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression. Mol Ther 2001;4:223-31.
9. Hemminki A, Kanerva A, Liu B, et al. Modulation of coxsackieadenovirus receptor expression for increased adenoviral transgene expression. Cancer Res 2003;63:847-53.
10. Kanerva A, Wang M, Bauerschmitz GJ, et al. Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses. Mol Ther 2002;5:695-704.
11. Lam JT, Bauerschmitz GJ, Kanerva A, et al. Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids. Cancer Gene Ther 2003;10:377-87.
12. Barker SD, Casado E, Gomez-Navarro J, et al. An immunomagnetic-based method for the purification of ovarian cancer cells from patient-derived ascites. Gynecol Oncol 2001;82:57-63.
13. White E, Denton A, Stillman B. Role of the adenovirus E1B 19,000-dalton tumor antigen in regulating early gene expression. J Virol 1988;62:3445-54.
14. Ganly I, Mautner V, Balmain A. Productive replication of human adenoviruses in mouse epidermal cells. J Virol 2000;74:2895-9.
15. Molin M, Akusjarvi G. Overexpression of essential splicing factor ASF/ SF2 blocks the temporal shift in adenovirus pre-mRNA splicing and reduces virus progeny formation. J Virol 2000;74:9002-9.
16. Ahuja D, Karow DS, Kilpatrick JE, Imperiale MJ. RNA polymerase II-dependent positional effects on mRNA 3′ end processing in the adenovirus major late transcription unit. J Biol Chem 2001;276:41825-31.
17. Klessig DF, Chow LT. Incomplete splicing and deficient accumulation of the fiber messenger RNA in monkey cells infected by human adenovirus type 2. J Mol Biol 1980;139:221-42.
18. Anderson KP, Klessig DF. Posttranscriptional block to synthesis of a human adenovirus capsid protein in abortively infected monkey cells. J Mol Appl Genet 1983;2:31-43.
19. Anderson KP, Klessig DF. Altered mRNA splicing in monkey cells abortively infected with human adenovirus may be responsible for inefficient synthesis of the virion fiber polypeptide. Proc Natl Acad Sci USA 1984;81:4023-7.
20. Johnston JM, Anderson KP, Klessig DF. Partial block to transcription of human adenovirus type 2 late genes in abortively infected monkey cells. J Virol 1985;56:378-85.
21. Klimkait T, Doerfler W. E1B functions of type C adenoviruses play a role in the complementation of blocked adenovirus type 12 DNA replication and late gene transcription in hamster cells. Virology 1987;161:109-20.
22. Lucher LA, Khuntirat B, Zhao J, Angeletti PC. Altered expression of adenovirus 12 DNA-binding protein but not DNA polymerase during abortive infection of hamster cells. Virology 1992;189:187-95.