Diverse effects of long-term treatment with imidapril and irbesartan on cell growth signal, apoptosis and collagen type I expression in the left ventricle of spontaneously hypertensive rats

Life Sciences

Volumn 75, Issue 4, 2004, Pages 407-420

  Wang, Jin Ming ^a   Wang, Ying ^a   Zhu, Zhong Sheng ^a   Zhang, Mei Chun ^a   Zou, Yi ^a   Li, Jian Jun ^a   Li, Ming Jiang ^a   Jiang, Xue Jun ^a   Li, Xiao Yan ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Imidapril; Irbesartan; Left ventricular remodeling; SHR

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; COLLAGEN TYPE 1; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMIDAPRIL; IRBESARTAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PLACEBO;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD PRESSURE; CELL GROWTH; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ESSENTIAL HYPERTENSION; GENE; GENE EXPRESSION; HEART LEFT VENTRICLE; HEART MUSCLE; HEART MUSCLE CELL; HOMEOSTASIS; INHIBITION KINETICS; LONG TERM CARE; MALE; NONHUMAN; PREDICTION; PROTEIN EXPRESSION; RANDOMIZATION; RAT; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA 1 GENE;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; APOPTOSIS; BIPHENYL COMPOUNDS; BLOOD PRESSURE; CELL CYCLE PROTEINS; COLLAGEN TYPE I; GENE EXPRESSION; HEART VENTRICLES; HYPERTENSION; IMIDAZOLES; IMIDAZOLIDINES; IMMEDIATE-EARLY PROTEINS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SIGNAL TRANSDUCTION; TETRAZOLES; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 2442526322     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.10.040     Document Type: Article

References (24)

1. Ando T., Okuda S., Tamaki K., Yoshitomi K., Fujishima M. Localization of transforming growth factor-β and latent transforming growth factor-β binding protein in rat kidney. Kidney International. 47(3):1995;733-739
2. Bastien N.R., Juneau A.V., Oueuette J., Lambert C. Chronic AT1 receptor blockade angiotensin-converting enzyme inhibition in (CHF 146) cardiomyopathic hamsters: effects on cardiac hypertrophy and survival. Cardiovascular Research. 43(1):1999;77-85
3. MAPK-Dependent Phosphorylation. Science. 286:1999;2514-2517
4. Bueno O.F., De Wind L.J., Lim H.W., Tymitz K.M., Witt S.A., Kimball T.R., Molkentin J.D. The dunl-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo. Circulation Research. 88(1):2001;88-96
5. Diez J., Panizo A., Hernandez M., Vega F., Sola I., Fortuno M.A., Pardo J. Cardiomyocyte apoptosis and cardiac angiotensin-converting enzyme in spontaneously hypertensive rats. Hypertension. 30(5):1997;1029-1034
6. Farhadian F., Contard F., Sabri A., Samuel J.L., Rappaport L. Fibronectin and basement membrane in cardiovascular organogenesis and disease pathogenesis. Cardiovascular Research. 32(3):1996;433-442
7. Ford W.R., Clanachan A.S., Jugdutt B.I. Characterization of cardioprotection mediated by AT2 receptor antagonism after ischemia-reperfusion in isolated working rat hearts. Journal of Cardiovascular Pharmacological Therapy. 5(3):2000;211-221
8. Gonzalez A., Lopez B., Ravassa S., Querejeta R., Larman M., Diez J. Stimulation of cardiac apoptosis in essential hypertension. Hypertension. 39(1):2002;75-80
9. Kacimi R., Gerdes A.M. Alterations in G protein and MAP kinase signaling pathways during cardiac Remodeling in Hypertension and Heart Failure. Hypertension. 41(4):2003;968-977
10. Kim S., Iwao H. Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacological Reviews. 52(1):2000;11-34
11. Li C., Hu Y., Mayr M., Xu Q. Cyclic strain stress-induced mitogen-activated protein kinase (MAPK) phosphatase 1 expression in vascular smooth muscle cells is regulated by Ras/Rac-MAPK pathways. Journal of Biological Chemistry. 274(36):1999;25273-25280
12. Linz W., Wiemer G., Gohlke P., Unger T., Scholkens B.A. Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors. Pharmacological Reviews. 47(1):1995;25-49
13. Lu W., Liu P.Q., Wang T.H., et al. Role of mitogen-activated protein kinase in the inhibition of myocardial hypertrophy by nitric oxide in renovascular hypertensive rats. Sheng Li Xue Bao. 53(1):2001;32-36. (Chinese)
14. McDonald K.M., Mock J., D'Aloia A., Parrish T., Hauer K., Francis G., Stillman A., Cohn J.N. Bradykinin antagonism inhibits the antigrowth effect of converting enzyme inhibition in the dog myocardium after discrete transmural myocardial necrosis. Circulation. 91(7):1995;2043-2048
15. de Moissac D., Gurevich R.M., Zheng H., Singal P.K., Kirshenbaum L.A. Caspase activation and mitochondrial cytochrome C release during hypoxia-madiated apoptosis of adult vebtricular myocytes. Journal of Molecular and Cellular Cardiology. 32(1):2000;53-63
16. Nakaya H., Sasamura H., Hayashi M., Saruta T. Temporary Treatment of Prepubescent Rats with Angiotensin Inhibitors Suppresses the Development of Hypertensive Nephrosclerosis. Journal of the American Society of Nephrology. 12(4):2001;659-666
17. 1 during differentiation of cardiac fibroblasts to myofibroblasts. Hypertension. 39(2):2002;258-263
18. Pitt B., Poole-Wilson P.A., Segal R., Martinez F.A., Dickstein K., Camm A.J., Konstam M.A., Riegger G., Klinger G.H., Neaton J., Sharma D., Thiyagarajan B. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure, randomised trial-the Losartan Heart Failure Survival Study ELITE II. Lancet. 355(9215):2000;1582-1587
19. Ravassa S., Fortuño M.A., González A., Lopez B., Zalba G., Fortuno A., Diez J. Mechanisms of increased susceptibility to angiotensin II-induced apoptosis in ventricular cardiomyocytes of spontaneously hypertensive rats. Hypertension. 36(6):2000;1065-1071
20. Sugimoto K., Fujimura A. Role of bradykinin in the reduction of left ventricular hypertrophy induce by angiotensin-converting enzyme inhibitors in spontaneously hypertensive rats. Japanese Journal of Pharmacology. 76(4):1998;431-434
21. Swynghedauw B. Molecular mechanism of myocardial remolding. Physiological Reviews. 79(1):1999;215-262
22. Touyz R.M., He G., Mabrouk M., Diep Q., Mardigyan V., Schiffrin E.L. Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated protein kinases by AT1 receptors in vascular smooth muscle cells from Wistar-Yyoto rats and spontaneously hypertensive rats. Journal of Hypertension. 19(3 pt 2):2001;553-559
23. Urata H., Healy B., Stewart R.W., Bumpus F.M., Husain A. Angiotensin II-forming pathways in normal and failing human hearts. Circulation Research. 66(4):1990;883-890
24. Zhu Y.C., Zhu Y.Z., Gohlke P., Stauss H.M., Unger T. Effects of angiotensin-converting enzyme inhibition and angiotensin II AT1 receptor antagonism on cardiac parameters in left ventricular hypertrophy. American Journal of Cardiology. 80(3A):1997;110A-117A