Interaction with the S1β-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 12, 2004, Pages 3063-3068

  Wendt, Michael D ^a   Geyer, Andrew ^a   McClellan, William J ^a   Rockway, Todd W ^a   Weitzberg, Moshe ^a   Zhao, Xumiao ^a   Mantei, Robert ^a   Stewart, Kent ^a   Nienaber, Vicki ^a   Klinghofer, Vered ^a   Giranda, Vincent L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Urokinase inhibitors

Indexed keywords

AMIDINE; PLASMINOGEN ACTIVATOR INHIBITOR; SULFONE; UROKINASE;

ARTICLE; BINDING AFFINITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; MOLECULAR INTERACTION; PHARMACODYNAMICS; STRUCTURE ANALYSIS;

BLOOD PROTEINS; NAPHTHALENES; SERINE PROTEINASE INHIBITORS; URINARY PLASMINOGEN ACTIVATOR;

EID: 2442497135     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.04.030     Document Type: Article

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