Infection with Oncolytic Herpes Simplex Virus-1 Induces Apoptosis in Neighboring Human Cancer Cells: A Potential Target to Increase Anticancer Activity

Clinical Cancer Research

Volumn 10, Issue 9, 2004, Pages 3225-3232

  Stanziale, Stephen F ^a   Petrowsky, Henrik ^a   Adusumilli, Prasad S ^a   Ben Porat, Leah ^a   Gonen, Mithat ^a   Fong, Yuman ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DACTINOMYCIN; GREEN FLUORESCENT PROTEIN; HOE 33342;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; DRUG EFFICACY; FLOW CYTOMETRY; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IN VITRO STUDY; MARKER GENE; NICK END LABELING; ONCOLYSIS; PRIORITY JOURNAL; STOMACH CANCER; VIRUS INFECTION; VIRUS REPLICATION;

ACETYLCYSTEINE; APOPTOSIS; CELL LINE, TUMOR; FLOW CYTOMETRY; GASTROINTESTINAL NEOPLASMS; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HERPESVIRUS 1, HUMAN; HUMANS; IN SITU NICK-END LABELING; LUMINESCENT PROTEINS;

EID: 2442492953     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-1083-3     Document Type: Article

References (64)

1. Ramakrishnan R, Fink DJ, Jiang G, et al. Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain. J Virol 1994;68:1864-73.
2. Jia WW, McDermott M, Goldie J, et al. Selective destruction of gliomas in immunocompetent rats by thymidine kinase-defective herpes simplex virus type 1 [see comments]. J Natl Cancer Inst (Bethesda) 1994;86:1209-15.
3. Andreansky S, Soroceanu L, Flotte ER, et al. Evaluation of genetically engineered herpes simplex viruses as oncolytic agents for human malignant brain tumors. Cancer Res 1997;57:1502-9.
4. Mineta T, Rabkin SD, Martuza RL. Treatment of malignant gliomas using ganciclovir-hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant. Cancer Res 1994;54:3963-6.
5. Chou J, Roizman B. The γ1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells. Proc Natl Acad Sci USA 1992;89:3266-70.
6. r 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 α and premature shutoff of protein synthesis after infection with γ134.5- mutants of herpes simplex virus 1. Proc Natl Acad Sci USA 1995;92:10516-20.
7. He B, Chou J, Brandimarti R, et al. Suppression of the phenotype of γ(1)34.5- herpes simplex virus i: failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the α47 gene. J Virol 1997;71:6049-54.
8. Leopardi R, Roizman B. The herpes simplex virus major regulatory protein ICP4 blocks apoptosis induced by the virus or by hyperthermia. Proc Natl Acad Sci USA 1996;93:9583-7.
9. Koyama AH, Miwa Y. Suppression of apoptotic DNA fragmentation in herpes simplex virus type 1-infected cells. J Virol 1997;71:2567-71.
10. Galvan V, Roizman B. Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner. Proc Natl Acad Sci USA 1998;95:3931-6.
11. Leopardi R, Van Sant C, Roizman B. The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus. Proc Natl Acad Sci USA 1997;94:7891-6.
12. Jerome KR, Tait JF, Koelle DM, Corey L. Herpes simplex virus type 1 renders infected cells resistant to cytotoxic T-lymphocyte-induced apoptosis. J Virol 1998;72:436-41.
13. Aubert M, Blaho JA. The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells. J Virol 1999;73:2803-13.
14. Meyaard L, Otto SA, Jonker RR, et al. Programmed death of T cells in HIV-1 infection. Science (Wash DC) 1992;257:217-9.
15. Groux H, Torpier G, Monte D, et al. Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med 1992;175:331-40.
16. Oyaizu N, Adachi Y, Hashimoto F, et al. Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection. J Immunol 1997;158:2456-63.
17. Lewis DE, Tang DS, Adu-Oppong A, Schober W, Rodgers JR. Anergy and apoptosis in CD8+ T cells from HIV-infected persons. J Immunol 1994;153:412-20.
18. Ullrich CK, Groopman JE, Ganju RK. HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases. Blood 2000;96:1438-42.
19. Gougeon ML, Garcia S, Heeney J, et al. Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res Hum Retroviruses 1993;9:553-63.
20. Meyaard L, Otto SA, Keet IP, Roos MT, Miedema F. Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease. J Clin Investig 1994;93:982-8.
21. Martin SJ, Matear PM, Vyakarnam A. HIV-1 infection of human CD4+ T cells in vitro. Differential induction of apoptosis in these cells. J Immunol 1994;152:330-42.
22. Terai C, Kornbluth RS, Pauza CD, Richman DD, Carson DA. Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. J Clin Investig 1991;87:1710-5.
23. Sarin A, Clerici M, Blatt SP, et al. Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. J Immunol 1994;153: 862-72.
24. Badley AD, McElhinny JA, Leibson PJ, et al. Upregulation of Fas ligand expression by human immunodeficiency virus in humah macrophages mediates apoptosis of uninfected T lymphocytes. J Virol 1996; 70:199-206.
25. Carbonari M, Pesce AM, Cibati M, et al. Death of bystander cells by a novel pathway involving early mitochondrial damage in human immunodeficiency virus-related lymphadenopathy. Blood 1997;90:209-16.
26. Finkel TH, Tudor-Williams G, Banda NK, et al. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nat Med 1995;1:129-34.
27. Herbein G, Van Lint C, Lovett JL, Verdin E. Distinct mechanisms trigger apoptosis in human immunodeficiency virus type 1-infected and in uninfected bystander T lymphocytes. J Virol 1998;72:660-70.
28. Banda NK, Bernier J, Kurahara DK, et al. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J Exp Med 1992;176:1099-106.
29. Li CJ, Friedman DJ, Wang C, Metelev V, Pardee AB. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science (Wash DC) 1995;268:429-31.
30. Westendorp MO, Frank R, Ochsenbauer C, et al. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature (Lond.) 1995;375:497-500.
31. Parlato S, Santini SM, Lapenta C, et al. Primary HIV-1 infection of human CD4+ T cells passaged into SCID mice leads to selection of chronically infected cells through a massive fas-mediated autocrine suicide of uninfected cells. Cell Death Differ 2000;7:37-47.
32. Wong RJ, Joe JK, Kim SH, et al. Oncolytic herpesvirus effectively treats murine squamous cell carcinoma and spreads by natural lymphatics to treat sites of lymphatic metastases. Hum Gene Ther 2002;13: 1213-23.
33. Shimamura T, Nakajima Y, Une Y, et al. Efficacy and safety of preoperative percutaneous transhepatic portal embolization with absolute ethanol: a clinical study. Surgery 1997;121:135-41.
34. Kleeff J, Kommann M, Sawhney H, Korc M. Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. Int J Cancer 2000;86:399-407.
35. Darzynkiewicz Z, Traganos F. Measurement of apoptosis. Adv Biochem Eng Biotechnol 1998;62:33-73.
36. Monier K, Armas JC, Etteldorf S, Ghazal P, Sullivan KF. Annexation of the interchromosomal space during viral infection. Nat Cell Biol 2000;2:661-5.
37. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993;75:241-51.
38. Kane DJ, Sarafian TA, Anton R, et al. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science (Wash DC) 1993;262:1274-7.
39. Abello PA, Fidler SA, Bulkley GB, Buchman TG. Antioxidants modulate induction of programmed endothelial cell death (apoptosis) by endotoxin. Arch Surg 1994;129:134-40.
40. Darzynkiewicz Z, Bedner E, Traganos F, Murakami T. Critical aspects in the analysis of apoptosis and necrosis. Hum Cell 1998;11: 3-12.
41. Shen Y, Shenk TE. Viruses and apoptosis. Curr Opin Genet Dev 1995;5:105-11.
42. Razvi ES, Welsh RM. Apoptosis in viral infections. Adv Virus Res 1995;45:1-60.
43. Secchiero P, Flamand L, Gibellini D, et al. Human herpesvirus 7 induces CD4(+) T-cell death by two distinct mechanisms: necrotic lysis in productively infected cells and apoptosis in uninfected or nonproductively infected cells. Blood 1997;90:4502-12.
44. Koyama AH, Adachi A. Induction of apoptosis by herpes simplex virus type 1. J Gen Virol 1997;78:2909-12.
45. Jacobs A, Dubrovin M, Hewett J, et al. Functional coexpression of HSV-1 thymidine kinase and green fluorescent protein: implications for noninvasive imaging of transgene expression. Neoplasia 1999;1: 154-61.
46. Paquin A, Jaalouk DE, Galipeau J. Retrovector encoding a green fluorescent protein-herpes simplex virus thymidine kinase fusion protein serves as a versatile suicide/reporter for cell and gene therapy applications. Hum Gene Ther 2001;12:13-23.
47. Advani SJ, Chung SM, Yan SY, et al. Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors. Cancer Res 1999;59:2055-8.
48. Carew JF, Kooby DA, Halterman MW, Federoff HJ, Fong Y. Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207). Hum Gene Ther 1999;10:1599-606.
49. Kooby DA, Carew JF, Halterman MW, et al. Oncolytic viral therapy for human colorectal cancer and liver metastases using a multimutated herpes simplex virus type-1 (G207). FASEB J 1999;6:499-504.
50. Oyama M, Ohigashi T, Hoshi M, et al. Treatment of human renal cell carcinoma by a conditionally replicating herpes vector G207. J Urol 2001;165:1274-8.
51. Petrowsky H, Roberts GD, Kooby DA, et al. Functional interaction between fluorodeoxyuridine-induced cellular alterations and replication of a ribonucleotide reductase-negative herpes simplex virus. J Virol 2001;75:7050-8.
52. Todo T, Rabkin SD, Chahlavi A, Martuza RL. Corticosteroid administration does not affect viral oncolytic activity, but inhibits antitumor immunity in replication-competent herpes simplex virus tumor therapy 2. Hum Gene Ther 1999;10:2869-78.
53. Yoon SS, Nakamura H, Carroll NM, et al. An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma. FASEB J 2000;14:301-11.
54. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-57.
55. Williams GT. Programmed cell death: apoptosis and oncogenesis. Cell 1991;65:1097-8.
56. Teodoro JG, Branton PE. Regulation of apoptosis by viral gene products. J Virol 1997;71:1739-46.
57. Aubert M, Blaho JA. Modulation of apoptosis during herpes simplex virus infection in human cells. Microbes Infect 2001;3:859-66.
58. Ito M, Watanabe M, Kamiya H, Sakurai M. Herpes simplex virus type 1 induces apoptosis in peripheral blood T lymphocytes. J Infect Dis 1997;175:1220-4.
59. Godfraind C, Holmes KV, Coutelier JP. Thymus involution induced by mouse hepatitis virus A59 in BALB/c mice. J Virol 1995;69:6541-7.
60. Ramiro-Ibanez F, Ortega A, Brun A, Escribano JM, Alonso C. Apoptosis: a mechanism of cell killing and lymphoid organ impairment during acute African swine fever virus infection. J Gen Virol 1996;77: 2209-19.
61. Sirinarumitr T, Zhang Y, Kluge JP, Halbur PG, Paul PS. A pneumovirulent United States isolate of porcine reproductive and respiratory syndrome virus induces apoptosis in bystander cells both in vitro and in vivo. J Gen Virol 1998;79:2989-95.
62. Inoue Y, Yasukawa M, Fujita S. Induction of T-cell apoptosis by human herpesvirus 6. J Virol 1997;71:3751-9.
63. Meyaard L, Miedema F. Programmed death of T cells in the course of HIV infection. Adv Exp Med Biol 1995;374:115-20.
64. Spear MA, Sun F, Eling DJ, et al. Cytotoxicity, apoptosis, and viral replication in tumor cells treated with oncolytic ribonucleotide reductase-defective herpes simplex type 1 virus (hrR3) combined with ionizing radiation. Cancer Gene Ther 2000;7:1051-9.