Death of bystander cells by a novel pathway involving early mitochondrial damage in human immunodeficiency virus-related lymphadenopathy

Blood

Volumn 90, Issue 1, 1997, Pages 209-216

  Carbonari, Maurizio ^b   Pesce, Anna Maria ^b   Cibati, Marina ^b   Modica, Alessandro ^b   Dell'Anna, Lucia ^b   D'Offizi, Giampiero ^b   Angelici, Alberto ^b   Uccini, Stefania ^b   Modesti, Andrea ^b   Fiorilli, Massimo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DNA FRAGMENT; VIRUS DNA;

ADULT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL DEATH; CHROMATIN CONDENSATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; LYMPHADENOPATHY; MALE; MITOCHONDRION; PRIORITY JOURNAL; PROVIRUS;

EID: 17644431629     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.1.209     Document Type: Article

References (56)

1. Schwartz LM, Osborne BA: Programmed cell death, apoptosis and killer genes. Immunol Today 14:582, 1993
2. Cohen JJ: Apoptosis. Immunol Today 14:126, 1993
3. Howie SEM, Harrison DJ, Wyllie AH: Lymphocyte apoptosis. Mechanisms and implications in disease. Immunol Rev. 142:141, 1994
4. Majno G, Joris I: Apoptosis, oncosis and necrosis: An overview of cell death. Am J Pathol 146:3, 1995
5. Ameisen JC: Programmed cell death (apoptosis) and cell survival regulation: Relevance to AIDS and cancer. AIDS 8:1197, 1994
6. Finkel TH, Tudor-Williams G, Banda NK, Cotton MF, Curiel T, Monks C, Baba TW, Ruprecht RM, Kupfer A: Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV-and SIV-infected lymph nodes. Nat Med 1:129, 1995
7. Muro-Cacho CA, Pantaleo G, Fauci AS: Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J Immunol 154:5555, 1995
8. + patients. Am J Pathol 146:1542, 1995
9. Pantaleo G, Graziosi C, Butini L, Pizzo PA, Schnittman SM, Kötler DP, Fauci AS: Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc Natl Acad Sci USA 88:9838, 1991
10. Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP, Fauci AS: HIV infection is active and progressive in lymphoid tissues during the clinically latent stage of disease. Nature 362:355, 1993
11. Embretson J, Zupancic M, Ribas JL, Burke A, Racz P, Tenner-Racz K, Haase AT: Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362:359, 1993
12. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keet RPM, Miedema F: Programmed cell death of T cells in HIV-1 infection. Science 257:217, 1992
13. Gougeon ML, Garcia S, Heeney S, Tschopp R, Lecoeur H, Guetard D, Rame V, Dauguet C, Montagnier L: Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res Hum Retroviruses 9:553, 1993
14. + T cells from HIV-infected persons. J Immunol 153:412, 1994
15. Meyaard L, Otto SA, Keet RPM, Roos MTL, Miedema F: Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease. J Clin Invest 93:982, 1994
16. Carbonari M, Cibati M, Pesce AM, Sbarigia D, Grossi PF, D'Offizi G, Luzi G, Fiorilli M: Frequency of provirus-bearing CD4 cells in HIV type 1 infection correlates with extent of in vitro apoptosis of CD8+ but not of CD4+ cells. AIDS Res Hum Retroviruses 11:789, 1995
17. Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, Saag MS, Shaw GM: Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373:117, 1995
18. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123, 1995
19. Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493, 1992
20. Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, Lassota P, Traganos F: Features of apoptotic cells measured by flow cytometry. Cytometry 13:795, 1992
21. Telford WG, King LE, Fraker PJ: Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry. J Immunol Meth 172:1, 1994
22. Carbonari M, Cibati M, Cherchi M, Sbarigia D, Pesce AM, Dell'Anna L, Modica A, Fiorilli M: Detection and characterization of apoptotic peripheral blood lymphocytes in HIV infection and cancer chemotherapy by a novel flow immunocytometric method. Blood 83:1268, 1994
23. Carbonari M, Cibati M, Fiorilli M: Measurement of apoptosis in peripheral blood. Cytometry 22:161, 1995
24. Pesce AM, Cibati M, Dell'Anna L, Fiorilli M, Carbonari M: Optimization of quantitative coamplification of β-globin and HIV-1 sequences. Trends Genet 12:447, 1996
25. Lewis W, Gonzalez B, Chomyn A, Papoian T: Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria. J Clin Invest 89:1354, 1992
26. Mower DA, Packham DW, Illera VA, Fishbaugh JK, Stunz LL, Ashman RF: Decreased membrane phospholipid packing and decreased cell size precede DNA cleavage in mature mouse B cell apoptosis. J Immunol 152: 4832, 1994
27. Sun AY, Jiang S, Zheng LM, Ojcius DM, Young J-DE: Separate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensation. J Exp Med 179:559, 1994
28. Boe R, Gjertsen BT, Vintermyr OK, Houge G, Lanotte M, Doskeland SO: The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp Cell Res 195:237, 1991
29. Oberhammer FA, Pavelka M, Sharma S, Tiefenbacher R, Purchio AF, Bursch W, Schulte-Hermann RS: Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor b1. Proc Natl Acad Sci USA 89:5408, 1992
30. Klaus SJ, Sidorenko SP, Clark EA: CD45 ligation induces programmed cell death in T and B lymphocytes. J Immunol 156:2743, 1996
31. Papadimitriou JC, Drachenberg CB, Shin ML, Trump BF: Ultrastructural studies of complement mediated cell death: A biological reaction model to plasma membrane injury. Virchows Arch 424:677, 1994
32. Akagi Y, Ito K, Sawada S: Radiation-induced apoptosis and necrosis in MOLT-4 cells: A study of dose-effect relationship and their modifications. Int J Radiat Biol 64:47, 1993
33. Tidball JG, Albrecht DE, Lokensgard BE, Spencer MJ: Apoptosis precedes necrosis of dystrophin-deficient muscle. J Cell Sci 108:2197, 1995
34. Zamzami N, Susin SA, Marchetti P, Hirsch T, Gomez-Monterrey I, Castedo M, Kroemer G: Mitochondrial control of nuclear apoptosis. J Exp Med 183:1533, 1996
35. Henkart PA, Grinstein S: Apoptosis: Mitochondria resurrected? J Exp Med 183:1293, 1996
36. Schulze-Osthoff K, Bakker AC, Vanhaesebroeck B, Beyaert R, Jacob WA, Fiers W: Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial function. Evidence for the involvement of mitochondrial radical generation. J Biol Chem 267:5317, 1992
37. Laster SM, Wood JG, Gooding LR: Tumor necrosis factor can induce both apoptotic and necrotic forms of cell lysis. J Immunol 141:2629, 1988
38. Lennon SV, Martin SJ, Cotter TG: Dose-dependent induction of apoptosis in human tumour cell lines by widely divergent stimuli. Cell Prolif 24:203, 1991.
39. Bonfoco E, Krainc D, Ankarkrona M, Nicotera P, Lipton SA: Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/ superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92:7162, 1995
40. Lin K-T, Xue J-Y, Nomen M, Spur B, Wong PYK: Peroxinitrite-induced apoptosis in HL-60 cells. J Biol Chem 270:16487, 1995
41. Macho A, Castedo M, Marchetti P, Aguilar JJ, Decaudin D, Zamzami N, Girard PM, Uriel J, Kroemer G: Mitochondrial dysfunctions in circulating T lymphocytes from human immunodeficiency virus-1 carriers. Blood 86:2481, 1995
42. Somasundaran M, Zapp ML, Beattie LK, Pang L, Byron KS, Bassell GJ, Sullivan JL, Singer RH: Localization of HIV RNA in mitochondria of infected cells: potential role in cytopathogenicity. J Cell Biol 126:1353, 1994
43. Westendorp MO, Shatrov VA, Schulze-Osthoff K, Frank R, Kraft M, Los M, Krammer PH, Dröge W, Lehmann V: HIV-1 Tat potentiates TNF-induced NF-kB activation and cytotoxicity by altering the cellular redox state. EMBO J 14:546, 1995
44. Baruchel S, Wainberg MA: The role of oxidative stress in disease progression in individuals infected by the human immunodeficiency virus. J Leukoc Biol 52:111, 1992
45. Buttke TM, Sandstrom PA: Oxidative stress as a mediator of apoptosis. Immunol Today 15:7, 1994
46. Emilie D, Fior R, Llorente L, Marfaing-Koka A, Peuchmaur M, Devergne O, Jarrousse B, Vijdenes J, Boue F, Galanaud P: Cytokines from lymphoid organs of HIV-infected patients: production and role in the immune disequilibrium of the disease and in the development of B lymphomas. Immunol Rev 140:5, 1994
47. Matsuyama T, Kobayashi N, Yamamoto N: Cytokines and HIV infection: Is AIDS a tumor necrosis factor disease? AIDS 5:1405, 1991
48. Pantaleo G, Graziosi C, Fauci AS: The immunopathogenesis of human immunodeficiency virus infection. N Engl J Med 328:327, 1993
49. Baroni CD, Pezzella F, Stoppacciaro A, Mirolo M, Pescarmona E, Vitolo D, Cassano AM, Barsotti P, Nicoletti L, Ruco LP, Uccini S: Systemic lymphadenopathy (LAS) in intravenous drug abusers. Histology, immunohistochemistry and electron microscopy: Pathogenetic correlations. Histopathology 9:1275, 1985
50. Burke AP, Anderson D, Mannan P, Ribas JL, Liang YH, Smialek J, Virmani R: Systemic lymphadenopathic histology in human immunodeficiency virus-1-seropositive drug addicts without apparent immunodeficiency syndrome. Hum Pathol 25:248, 1994
51. Pantaleo G, Graziosi C, Demurest JF, Cohen OJ, Vaccarezza M, Gantt K, Muro-Cacho C, Fauci AS: Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol Rev 140:105, 1994
52. Zinkernagel RM, Hengartner H: T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS. Immunol Today 15:262, 1994
53. Mosier D, Sieburg H: Macrophage-tropic HIV: Critical for AIDS pathogenesis? Immunol Today 15:332, 1994
54. Razvi ES, Welsh RM: Programmed cell death of T lymphocytes during acute viral infection: A mechanism for virus-induced immune deficiency. J Virol 67:5754, 1993
55. Akbar AN, Borthwick N, Salmon M, Gombert W, Bofill M, Shamsaaden N, Pilling D, Pett S, Grundy JE, Janossy G: The significance of low bcl-2 expression by CD45RO T cells in normal individuals and in patients with acute viral infections. The role of apoptosis in T cell memory. J Exp Med 178:427, 1993.
56. Rimaniol AC, Zylberberg H, Zavala F, Viard JP: Inflammatory cytokines and inhibitors in HIV infection: Correlation between interleukin-1 receptor antagonist and weight loss. AIDS 10:1349, 1996