Systemic bone formation with weekly PTH administration in ovariectomized rats

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 7, Issue 1, 2004, Pages 27-37

  Gittens, Sébastien A ^a   Wohl, Gregory R ^a   Zernicke, Ronald F ^b   Matyas, John R ^b   Morley, Paul ^c   Uludag, Hasan ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE[1-34];

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MINERAL; BONE TISSUE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; HORMONE SYNTHESIS; NONHUMAN; OSSIFICATION; OVARIECTOMY; RAT; STRUCTURE ANALYSIS; TRABECULAR BONE;

ANIMALS; BODY MASS INDEX; BONE DENSITY; FEMALE; LUMBAR VERTEBRAE; OSTEOGENESIS; OVARIECTOMY; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; TIBIA;

EID: 2442456771     PISSN: 14821826     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Uzawa T, Hori M, Ejiri S, Ozawa H (1995) Comparison of the effects of intermittent and continuous administration of human parathyroid hormone (1-34) on rat bone. Bone 16: 477-484
2. Lotinun S, Sibonga JD, Turner RT (2002) Differential effects of intermittent and continuous administration of parathyroid hormone on bone histomorphometry and gene expression. Endocrine 17:29-36
3. Shen V, Birchman R, Wu DD, Lindsay R (2000) Skeletal effects of parathyroid hormone infusion in ovariectomized rats with or without estrogen repletion. J Bone Min Res 15: 740-746
4. Hock JM, Fonseca J, Gunness-Hey M, Kemp BE, Martin TJ (1989) Comparison of the anabolic effects of synthetic parathyroid hormone-related protein (PTHrP) 1-34 and PTH 1-34 on bone in rats. Endocrinol 125:2022-2027
5. Gunness-Hey M, Hock JM (1989) Loss of the anabolic effect of parathyroid hormone on bone after discontinuation of hormone in rats. Bone 10:447-452
6. Oxlund H, Ejersted C, Andreassen TT, Torring O, Nilsson MH (1993) Parathyroid hormone (1-34) and (1-84) stimulate cortical bone formation both from periosteum and endosteum. Calcif Tissue Int 53:394-399
7. Gunness-Hey M, Hock JM (1984) Increased trabecular bone mass in rats treated with human synthetic parathyroid hormone. Metab Bone Dis Relat Res 5:177-181
8. Moriyama I, Iwamoto J, Takeda T, Toyama Y (2002) Comparative effects of intermittent administration of human parathyroid hormone (1-34) on trabecular and cortical bone loss in tail-suspended and sciatic neurectomized young rats. J Orthop Sci 7:379-385
9. Halloran BP, Bikle DD, Harris J, Tanner S, Curren T, Morey-Holton E (1997) Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading. J Bone Miner Res 12:1068-1074
10. Ogawa T, Yamagiwa H, Hayami T, Liu Z, Huang KY, Tokunaga K, Murai T, Endo N (2002) Human PTH (1-34) induces longitudinal bone growth in rats. J Bone Miner Metab 20:83-90.
11. Oxlund H, Dalstra M, Ejersted C, Andreassen TT (2002) Parathyroid hormone induces formation of new trabecular bone with substantial mechanical strength at a site where it had disappeared in old rats. Eur J Endocrinol 146:431-438
12. Ejersted C, Andreassen TT, Nilsson MH, Oxlund H (1994) Human parathyroid hormone (1-34) increases bone formation and strength of cortical bone in aged rats. Eur J Endocrinol 130:201-207
13. Ejersted C, Andreassen TT, Hauge EM, Melsen F, Oxlund H (1995) Parathyroid hormone (1-34) increases vertebral bone mass, compressive strength, and quality in old rats. Bone 17:507-511
14. Ejersted C, Andreassen TT, Oxlund H, Jorgensen PH, Bak B, Haggblad J, Torring O, Nilsson MH (1993) Human parathyroid hormone (1-34) and (1-84) increase the mechanical strength and thickness of cortical bone in rats. J Bone Miner Res 8:1097-1101
15. Ejersted C, Oxlund H, Andreassen TT (1998) Bisphosphonate maintains parathyroid hormone (1-34)-induced cortical bone mass and mechanical strength in old rats. Calcif Tissue Int 62:316-322
16. Simmons HA, Pirie CM, Thompson DD, Ke HZ (1998) Parathyroid hormone (1-34) increased total body bone mass in aged female rats. J Pharmacol Exp Ther 286:341-344
17. Mitlak BH, Williams DC, Bryant HU, Paul DC, Neer RM (1992) Intermittent administration of bovine PTH-(1-34) increases serum 1,25-dihydroxyvitamin D concentrations and spinal bone density in senile (23 monthmonth) rats. J Bone Miner Res 7:479-484
18. Tsuchida T, Sato K, Miyakoshi N, Abe T, Kudo T, Tamura Y, Kasukawa Y, Suzuki K (2000) Histomorphometric evaluation of the recovering effect of human parathyroid hormone (1-34) on bone structure and turnover in streptozotocin-induced diabetic rats. Calcif Tissue Int 66:229-233
19. Hock JM, Gera I, Fonseca J, Raisz LG (1988) Human parathyroid hormone-(1-34) increases bone mass in ovariectomized and orchidectomized rats. Endocrinology 122:2899-2904
20. Thompson DD, Simmons HA, Pirie CM, Ze HZ (1995) FDA guidelines and animal models for osteoporosis. Bone 16:157-161
21. Morley P, Whitfield JF, Willick GE (2001) Parathyroid hormone: an anabolic treatment for osteoporosis. Curr Pharm Des 7:671-687
22. Dempster DW, Cosman F, Parisien M, Shen V, Lindsay R. (1993) Anabolic actions of parathyroid hormone on bone. Endocr Rev. 14:690-709.
23. Li M, Wronski TJ (1995) Response of femoral neck to estrogen depletion and parathyroid hormone in aged rats. Bone 16:551-557
24. Kneissel M, Boyde A, Gasser JA (2001) Bone tissue and its mineralization in aged estrogen-depleted rats after long-term intermittent treatment with parathyroid hormone (PTH) analog SDZ PTS 893 or human PTH(1-34). Bone 28:237-250
25. Sato M, Zeng GQ, Turner CH (1997) Biosynthetic human parathyroid hormone (1-34) effects on bone quality in aged ovariectomized rats. Endocrinology 138:4330-4337
26. Oxlund H, Dalstra M, Ejersted C, Andreassen TT (2002) Parathyroid hormone induces formation of new cancellous bone with substantial mechanical strength at a site where it had disappeared in old rats. Eur J Endocrinol 146:431-438.
27. Vahle JL, Sato M, Long GG, Young JK, Francis PC, Engelhardt JA, Westmore MS, Linda Y, Nold JB (2002) Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety. Toxicol Pathol 30:312-321
28. Sato M, Ma YL, Hock JM, Westmore MS, Vahle J, Villanueva A, Turner CH (2002) Skeletal efficacy with parathyroid hormone in rats was not entirely beneficial with long-term treatment. J Pharmacol Exp Ther 302:304-313
29. Crandall C (2002) Parathyroid hormone for treatment of osteoporosis. Arch Intern Med. 162:2297-2309.
30. Bain S, Ramamurthy NS, Impeduglia T, Scolman S, Golub LM, Rubin (1997) Tetracycline prevents trabecular bone loss and maintains near-normal rates of bone formation in streptozotocin diabetic rats. Bone 21:147-153
31. Feldkamp LA, Davis LC, Kress JW (1984) Practical cone-beam algorithm. J Opt Soc Am - A 1: 612-619
32. Glaseby CA (1993) An Analysis of Histogram-Based Thresholding Algorithms. CVGIP: Graphical Models and Image Processing 55:532-537
33. Mosekilde L, Tornvig L, Thomsen JS, Orhii PB, Banu MJ, Kalu DN (2000) Parathyroid hormone and growth hormone have additive or synergetic effect when used as intervention treatment in ovariectomized rats with established osteopenia. Bone 26:643-651
34. Okimoto N, Tsurukami H, Okazaki Y, Nishida S, Sakai A, Ohnishi H, Hori M, Yasukawa K, Nakamura T (1998) Effects of a weekly injection of human parathyroid hormone (1-34) and withdrawal on bone mass, strength, and turnover in mature ovariectomized rats. Bone 22:523-531
35. Bouxsein ML, Myburgh KH, van der Meulen MC, Lindenberger E, Marcus R (1994) Age-related differences in cross-sectional geometry of the forearm bones in healthy women. Calcif Tissue Int 54:113-118
36. Judex S, Gross TS, Zernicke RF (1997) Strain gradients correlate with sites of exercise-induced boneforming surfaces in the adult skeleton. J Bone & Min Res 12:1737-1745
37. Turner RT, Evans GL, Cavolina JM, Halloran B, Morey-Holton E. (1998) Programmed administration of parathyroid hormone increases bone formation and reduces bone loss in hindlimb-unloaded ovariectomized rats. Endocrinology. 139:4086-4091
38. Gunness-Hey M, Hock JM (1989) Loss of the anabolic effect of parathyroid hormone on bone after discontinuation of hormone in rats. Bone 10:447-452
39. Fox J, Miller MA, Stroup GB, Nemeth EF, Miller SC (1997) Plasma levels of parathyroid hormone that induce anabolic effects in bone of ovariectomized rats can be achieved by stimulation of endogenous hormone secretion. Bone 21:163-169