Effects of human intestinal flora on plasma and caecal isoflavones, and effects of isoflavones on the composition and metabolism of flora in human flora-associated (HFA) mice

Microbial Ecology in Health and Disease

Volumn 16, Issue 1, 2004, Pages 18-22

  Tamura, Motoi ^a   Hirayama, Kazuhiro ^b   Itoh, Kikuji ^b   Shinohara, Kazuki ^a  

^a NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Daidzein; Genistein; Human flora associated (HFA) mice; Intestinal flora

Indexed keywords

BETA GLUCOSIDASE; BETA GLUCURONIDASE; DAIDZEIN; EQUOL; GENISTEIN; ISOFLAVONE; SOLVENT;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL FLORA; BACTERIAL METABOLISM; BLOOD LEVEL; CLOSTRIDIUM; CONTROLLED STUDY; DIETARY INTAKE; ENZYME ACTIVITY; FECES ANALYSIS; FECES LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE ABSORPTION; INTESTINE FLORA; MICROBIAL METABOLISM; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; BACTERIA (MICROORGANISMS); CLOSTRIDIA; CLOSTRIDIUM; GLYCINE MAX;

EID: 2442454565     PISSN: 0891060X     EISSN: None     Source Type: Journal    
DOI: 10.1080/08910600410027985     Document Type: Article

References (21)

1. Adlercreutz H, Goldin BR, Gorbach SL, Hökerstedt KAV, Watanabe S, Hämäläinen EK, Markkanen MH, Mäkelä TH, Wähälä KT, Adlercreutz T. Soybean phytoestrogen intake and cancer risk. J Nutr 1995; 125: 757S-70S.
2. Vedavanam K, Srijayanta S, O'Reilly J, Raman A, Wiseman H. Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE). Phytother Res 1999; 13: 601-8.
3. Mitchell JH, Gardner PT, McPhail DB, Morrice PC, Collins AR, Duthie GG. Antioxidant efficacy of phytoestrogens in chemical and biological model systems. Arch Biochem Biophys 1998; 360: 142-8.
4. Shutt DA, Cox RI. Steroid and phyto-oestrogen binding to sheep uterine receptors in vitro. J Endocrinol 1972; 52: 299-310.
5. Ishida H, Uesugi T, Hirai K, Toda T, Nukaya H, Yokotsuka K, Tsuji K. Preventive effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized rats fed a calcium-deficient diet. Biol Pharm Bull 1998; 21: 62-6.
6. King RA, Bursill DB. Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in human. Am J Clin Nutr 1998; 67: 867-72.
7. Kelly GE, Joannou GE, Reeder AY, Nelson C, Waring MA. The variable metabolic response to dietary isoflavones in humans. Proc Soc Exp Biol Med 1995; 208: 40-3.
8. Xu X, Harris KS, Wang HJ, Murphy PA, Hendrich S. Bioavailability of soybean isoflavones depends upon gut microflora in women. J Nutr 1995; 125: 2307-15.
9. Adlercreutz H, Fotsis T, Heikkinen R, Dwyer JT, Woods M, Goldin BR, Gorbach SL. Excretion of the lignans euterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer. Lancet 1982; 2: 1295-9.
10. Bannwart C, Fotsis T, Heikkinen R, Adlercreutz H. Identification of isoflavonic phytoestrogen daidzein in human urine. Clin Chim Acta 1984; 136: 165-72.
11. Rowland IR, Wiseman H, Sanders TA, Adlercreutz H, Bowey EA. Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr Cancer 2000; 36: 27-32.
12. Hirayama K. Ex-germfree mice harboring intestinal microbiota derived from other animal species as an experimental model for ecology and metabolism of intestinal bacteria. Exp Anim 1999; 48: 219-27.
13. Rowland IR, Mallett AK, Wise A. A comparison of the activity of five microbial enzymes in cecal content from rats, mice, and hamsters, and response to dietary pectin. Toxicol Appl Pharmacol 1983; 69: 143-8.
14. Mitsuoka T, Ohno K, Benno Y, Suzuki K, Namba K. Die Faekalflora bei Menschen. IV. Mitteilung. Vergleich des neu entwickelten Verfahrens mit dem bisherigen üblichen Vertahren zur Darmfloraanalyse. Zentralbl Bakteriol [Orig A] 1976; 234: 219-33.
15. Mitsuoka T, Sega T, Yamamoto S. Eine verbesserte Methodik der qualitativen und quantitativen Analyse der Darmflora von Menschen und Tieren. Zentralbl Bakteriol [Orig A] 1965; 195: 455-69.
16. Itoh K, Mitsaoka T. Production of gnotobiotic mice with normal physiological function. I. Selection of useful bacteria from feces of conventional mice. Z Versuchstierkd 1980; 22: 173-8.
17. Setchell KD, Borriello SP, Hulme P, Kirk DN, Axelson M. Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease. Am J Clin Nutr 1984; 40: 569-78.
18. Karr SC, Lampe JW, Hutchins AM, Slavin JL. Urinary isoflavonoid excretion in humans is dose dependent at low to moderate levels of soy-protein consumption. Am J Clin Nutr 1997; 66: 46-51.
19. Lampe JW, Karr SC, Hutchins AM, Slavin JL. Urinary equol excretion with a soy challenge: influence of habitual diet. Proc Soc Exp Biol Med 1998; 217: 335-9.
20. Braune A, Gütschow M, Engst W, Blaut M. Degradation of quercetin and luteolin by Eubacterium ramulus. Appl Environ Microbiol 2001; 67: 5558-67.
21. Winter J, Moore LH, Dowell VR Jr, Bokkenheuser VD. C-ring cleavage of flavonoids by human intestinal bacteria. Appl Environ Microbiol 1989; 55: 1203-8.