Anemia associated with critical illness: Is the erythropoietin receptor a culprit?

Critical Care Medicine

Volumn 32, Issue 5, 2004, Pages 1234-1235

  Bar Or, David ^a   Kepros, John P ^a  

^a SWEDISH MEDICAL CENTER   (United States)

Author keywords

Anemia; Erythropoetin receptor; Iron; Sepsis

Indexed keywords

ADAPTOR PROTEIN; ASCORBIC ACID; ERYTHROPOIETIN RECEPTOR; FERRIC ION; FERROUS ION; HYDROXYL RADICAL; IRON; IRON DEXTRAN; JANUS KINASE; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; MONOMER; PROTEIN TYROSINE KINASE; REDUCING AGENT; STAT PROTEIN; SUPEROXIDE; THIOL DERIVATIVE; UBIQUITIN PROTEIN LIGASE;

ANEMIA; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELL TYPE; CONFORMATIONAL TRANSITION; CRITICAL ILLNESS; DIMERIZATION; DISEASE ASSOCIATION; DISULFIDE BOND; EDITORIAL; ELECTRON TRANSPORT; EPITHELIUM CELL; ERYTHROBLAST; ERYTHROPOIESIS; FENTON REACTION; GENE EXPRESSION REGULATION; HUMAN; INTESTINE EPITHELIUM; IRON METABOLISM; IRON THERAPY; LIGAND BINDING; NONHUMAN; OXIDATION REDUCTION REACTION; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SEPSIS; SIGNAL TRANSDUCTION; STRESS;

ANEMIA, IRON-DEFICIENCY; CAUSALITY; CRITICAL ILLNESS; HUMANS; IRON; RECEPTORS, ERYTHROPOIETIN; RESEARCH DESIGN; SEPSIS;

EID: 2442431593     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000125512.19069.19     Document Type: Editorial

References (14)

1. Patteril MV, Davey-Quinn AP, Gedney JA, et al: Functional iron deficiency, infection and systemic inflammatory response syndrome in critical illness. Anaesth Intensive Care 2001; 29:473-478
2. Rodriguez RM, Corwin HL, Gettinger A, et al: Nutritional deficiencies and blunted erythropoietin response as causes of the anemia of critical illness. J Crit Care 2001; 16:36-41
3. Eckardt KU: Anaemia of critical illness - implications for understanding and treating rHuEPO resistance. Nephrol Dial Transplant 2002; 17(Suppl 5):48-55
4. Walsh DS, Pattanapanyasat K, Lamchiagdhase P, et al: Iron status following trauma, excluding burns. Br J Surg 1996; 83:982-985
5. Javadi P, Buchman TG, Stromberg P, et al: High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis. Crit Care Med 2004; 32:1178-1185
6. Abel J, Spannbrucker N, Fandrey J, et al: Serum erythropoietin levels in patients with sepsis and septic shock. Eur J Haematol 1996; 57:359-363
7. Darveau M, Notebaert E, Denault AY, et al: Recombinant human erythropoietin use in intensive care. Ann Pharmacother 2002; 36: 1068-1074
8. Krafte-Jacobs B, Bock GH: Circulating erythropoietin and interleukin-6 concentrations increase in critically ill children with sepsis and septic shock. Crit Care Med 1996; 24:1455-1459
9. Sela S, Shurtz-Swirski R, Sharon R, et al: The polymorphonuclear leukocyte - a new target for erythropoietin. Nephron 2001; 88: 205-210
10. Cervi D, Truong AH, Lee JS, et al: Phosphorylation status of c-Kit and Epo receptors, and the presence of wild-type p53 confer in vitro resistance of murine erythroleukemic cells to Celecoxib. Oncogene 2004, In Press
11. Seubert N, Royer Y, Staerk J, et al: Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. Mol Cell 2003; 12: 1239-1250
12. Lebigot I, Gardellin P, Lefebvre L, et al: Upregulation of SLAP in FLI-1-transformed erythroblasts interferes with EpoR signaling. Blood 2003; 102:4555-4562
13. Galley HF, Davies MJ, Webster NR: Ascorbyl radical formation in patients with sepsis: Effect of ascorbate loading. Free Radic Biol Med 1996; 20:139-143
14. Friedman AD, Nimbalkar D, Quelle FW: Erythropoietin receptors associate with a ubiquitin ligase, p33RUL, and require its activity for erythropoietin-induced proliferation. J Biol Chem 2003; 278: 26851-26861