Analysis of a mitochondrial apoptotic pathway using bid-targeted ribozymes in human MCF7 cells in the absence of a caspase-3-dependent pathway

Antisense and Nucleic Acid Drug Development

Volumn 13, Issue 2, 2003, Pages 75-82

  Onuki, Reiko ^a,b   Kawasaki, Hiroaki ^a,c   Baba, Tadashi ^b   Taira, Kazunari ^a,c  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; PROTEIN BID; RIBOZYME; TUMOR NECROSIS FACTOR ALPHA; CYSTEINE PROTEINASE; PROCASPASE 7; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TARGETING; BREAST CARCINOMA; CELL STRAIN MCF 7; PROTEIN SECRETION;

EID: 24344481770     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/108729003321629629     Document Type: Article

References (28)

1. ADAMS, J.M., and CORY, S. (1998). The Bcl-2 protein family: Arbiters of cell survival. Science 281, 1322-1326.
2. BASU, A., JOHNSON, D., and WOOLARD, M. (2002). Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome c-independent pathway. Exp. Cell Res. 278, 209-214.
3. BOSSY-WETZEL, E., and GREEN, D.R. (1999). Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. J. Biol. Chem. 274, 17484-17490.
4. CROMPTON, M. (2000). Bax, Bid and the permeabilization of the mitochondrial outer membrane in apoptosis. Curr. Opin. Cell Biol. 12, 414-419.
5. HASELOFF, J., and GERLACH, W.L. (1988). Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature 334, 585-591.
6. JANICKE, R.U., SPRENGART, M.L., WATI, M.R., and PORTER, A.G. (1998). Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 273, 9357-9360.
7. KATO, Y., KUWABARA, T., WARASHINA, M., TODA, H., and TAIRA, K. (2001). Relationships between the activities in vitro and in vivo of various kinds of ribozyme and their intracellular localization in mammalian cells. J. Biol. Chem. 276, 15378-15385.
8. KAWASAKI, H., and TAIRA, K. (2003). Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells. Nucleic Acids Res. 31, 700-707.
9. KOSEKI, S., TANABE, T., TANI, K., ASANO, S., SHIODA, T., NAGAI, Y., SHIMADA, T., OHKAWA, J., and TAIRA, K. (1999). Factors governing the activity in vivo of ribozymes transcribed by RNA polymerase III. J. Virol. 73, 1868-1877.
10. KUWABARA, T., WARASHINA, M., KOSEKI, S., SANO, M., OHKAWA, J., NAKAYAMA, K., and TAIRA, K. (2001a). Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: Engineered tRNAs with an extended 3′ end can be exported efficiently and specifically to the cytoplasm in mammalian cells. Nucleic Acids Res. 29, 2780-2788.
11. KUWABARA, T., WARASHINA, M., SANO, M., TANG, H., WONG-STAAL, F., MUNEKATA, E., and TAIRA, K. (2001b). Recognition of engineered tRNAs with an extended 3′ end by Exportin-t (Xpo-t) and transport of tRNA-attached ribozymes to the cytoplasm in somatic cells. Biomacromolecules 2, 1229-1242.
12. KUWANA, T., MACKEY, M., PERKINS, G., ELLISMAN, M., LATTERICH, M., SCHNEITER, R., GREEN, D., and NEWMEYER, D. (2002). Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 111, 331-342.
13. LECHARDEUR, D., DRZYMALA, L., SHARMA, M., ZYLKA, D., KINACH, R., PACIA, J., HICKS, C., USMANI, N., ROMMENS, J., and LUKACS, G. (2000). Determinants of the nuclear localization of the heterodimeric DNA fragmentation factor (ICAD/CAD). J. Cell Biol. 150, 321-334.
14. LI, H., and YUAN, J. (1999). Deciphering the pathways of life and death. Curr. Opin. Cell Biol. 11, 261-266.
15. LI, P., NIJHAWAN, D., BUDIHARDJO, I., SRINIVASULA, S.M., AHMAD, M., ALNEMRI, E.S., and WANG, X. (1997). Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489.
16. ONUKI, R., NAGASAKI, A., KAWASAKI, H., BABA, T., UYEDA, T.Q., and TAIRA, K. (2002). Confirmation by FRET in individual living cells of the absence of significant amyloid (beta)-mediated caspase 8 activation. Proc. Natl. Acad. Sci. USA 99, 14716-14721.
17. ROUCOU, X., ROSTOVTSEVA, T., MONTESSUIT, S., MARTINOU, J., and ANTONSSON, B. (2002). Bid induces cytochrome c-impermeable Bax channels in liposomes. Biochem. J. 363, 547-552.
18. RUCHAUD, S., KORFALI, N., VILLA, P., KOTTKE, T., DINGWALL, C., KAUFMANN, S., and EARNSHAW, W. (2002). Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. EMBO J. 21, 1967-1977.
19. SRINIVASAN, A., LI, F., WONG, A., KODANDAPANI, L., SMIDT, R., Jr., KREBS, J.F., FRITZ, L.C., WU, J.C., and TOMASELLI, K.J. (1998). Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells. J. Biol. Chem. 273, 4523-4529.
20. SUN, X.M., MacFARLANE, M., ZHUANG, J., WOLF, B.B., GREEN, D.R., and COHEN, G.M. (1999). Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J. Biol. Chem. 274, 5053-5060.
21. SUYAMA, E., KAWASAKI, H., AND TAIRA, K. (2002). Identification of a caspase 3-independent role of pro-apoptotic factor Bak in TNF-alpha-induced apoptosis. FEBS Lett. 528, 63-69.
22. SYMONS, R.H. (1992). Small catalytic RNAs. Annu. Rev. Biochem. 61, 641-671.
23. UHLENBECK, O.C. (1987). A small catalytic oligoribonucleotide. Nature 328, 596-600.
24. WEI, M.C., LINDSTEN, T., MOOTHA, V.K., WEILER, S., GROSS, A., ASHIYA, M., THOMPSON, C.B., and KORSMEYER, S.J. (2000). tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14, 2060-2071.
25. WOLF, B.B., SCHULER, M., ECHEVERRI, F., and GREEN, D.R. (1999). Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation. J. Biol. Chem. 274, 30651-30656.
26. YIN, X.M., WANG, K., GROSS, A., ZHAO, Y., ZINKEL, S., KLOCKE, B., ROTH, K.A., and KORSMEYER, S.J. (1999). Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400, 886-891.
27. ZHA, J., WEILER, S., OH, K.J., WEI, M.C., and KORSMEYER, S.J. (2000). Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science 290, 1761-1765.
28. ZHOU, D.M., and TAIRA, K. (1998). The hydrolysis of RNA: From theoretical calculations to the hammerhead ribozyme-mediated cleavage of RNA. Chem. Rev. 98, 991-1026.