Phosphorylation of 9-β-D-arabinofuranosylguanine monophosphate by Drosophila melanogaster guanylate kinase

Biochemical Pharmacology

Volumn 70, Issue 7, 2005, Pages 987-992

  Johansson, Magnus ^a   Amiri, Marjan ^a   Karlsson, Anna ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Anti cancer therapy; Nucleoside analog; Nucleoside kinase; Nucleoside phosphorylation; Purine; Suicide gene therapy

Indexed keywords

2',2' DIFLUORODEOXYGUANOSINE MONOPHOSPHATE; 9BETA DEXTRO ARABINOFURANOSYLGUANINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; DEOXYGUANOSINE PHOSPHATE; GUANOSINE PHOSPHATE; GUANYLATE KINASE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; DROSOPHILA MELANOGASTER; ENZYME ANALYSIS; MOLECULAR CLONING; PHOSPHORYLATION; PREDICTION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ARABINONUCLEOTIDES; BASE SEQUENCE; CLONING, MOLECULAR; DNA PRIMERS; DNA, COMPLEMENTARY; DROSOPHILA MELANOGASTER; GUANYLATE KINASE; MOLECULAR SEQUENCE DATA; NUCLEOSIDE-PHOSPHATE KINASE; PHOSPHORYLATION; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 24344455169     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.06.023     Document Type: Article

References (17)

1. A.R. Van Rompay, M. Johansson, and A. Karlsson Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases Pharmacol Ther 100 2003 119 139
2. C.J. Springer, and I. Niculescu-Duvaz Prodrug-activating systems in suicide gene therapy J Clin Invest 105 2000 1161 1167
3. X. Zheng, M. Johansson, and A. Karlsson Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase J Biol Chem 275 2000 39125 39129
4. M. Johansson, A.R. Van Rompay, B. Degreve, J. Balzarini, and A. Karlsson Cloning and characterization of the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster J Biol Chem 274 1999 23814 23819
5. A. Lavie, I. Schlichting, I.R. Vetter, M. Konrad, J. Reinstein, and R.S. Goody The bottleneck in AZT activation Nat Med 3 1997 922 924
6. S. Gallois-Montbrun, B. Schneider, Y. Chen, V. Giacomoni-Fernandes, L. Mulard, and S. Morera Improving nucleoside diphosphate kinase for antiviral nucleotide analogs activation J Biol Chem 277 2002 39953 39959
7. A.R. Van Rompay, M. Johansson, and A. Karlsson Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme Mol Pharmacol 56 1999 562 569
8. J.Y. Liou, G.E. Dutschman, W. Lam, Z. Jiang, and Y.C. Cheng Characterization of human UMP/CMP kinase and its phosphorylation of d- and l-form deoxycytidine analogue monophosphates Cancer Res 62 2002 1624 1631
9. S. Curbo, M. Amiri, F. Foroogh, M. Johansson, and A. Karlsson The Drosophila melanogaster UMP-CMP kinase cDNA encodes an N-terminal mitochondrial import signal Biochem Biophys Res Commun 311 2003 440 445
10. S.F. Altschul, W. Gish, W. Miller, E.W. Myers, and D.J. Lipman Basic local alignment search tool J Mol Biol 215 1990 403 410
11. I.O. Gaidarov, O.N. Suslov, and N.G. Abdulaev Enzymes of the cyclic GMP metabolism in bovine retina. I. Cloning and expression of the gene for guanylate kinase FEBS Lett 335 1993 81 84
12. J. Fitzgibbon, N. Katsanis, D. Wells, J. Delhanty, W. Vallins, and D.M. Hunt Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation FEBS Lett 385 1996 185 188
13. W.A. Brady, M.S. Kokoris, M. Fitzgibbon, and M.E. Black Cloning, characterization, and modeling of mouse and human guanylate kinases J Biol Chem 271 1996 16734 16740
14. The FlyBase Consortium. The FlyBase database of the Drosophila genome projects and community literature. Nucleic Acids Res 2003;31:172-5.
15. K. Nakai, and P. Horton PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization Trends Biochem Sci 24 1999 34 36
16. A.R. Van Rompay, M. Johansson, and A. Karlsson Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases Pharmacol Ther 87 2000 189 198
17. J. Balzarini, P. Herdewijn, and E. De Clercq Differential patterns of intracellular metabolism of 2′,3′-didehydro-2′,3′- dideoxythymidine and 3′-azido-2′,3′-dideoxythymidine, two potent anti-human immunodeficiency virus compounds J Biol Chem 264 1989 6127 6133