메뉴 건너뛰기




Volumn 4, Issue 5, 2005, Pages 869-877

Safety of antiepileptic drugs during pregnancy

Author keywords

Antiepileptic drug; Birth defect; Epilepsy; Management; Pregnancy; Teratogenesis

Indexed keywords

ANTICONVULSIVE AGENT; BARBITURIC ACID DERIVATIVE; CARBAMAZEPINE; CLONAZEPAM; DIAZEPAM; ETIRACETAM; GABAPENTIN; LAMOTRIGINE; LORAZEPAM; MIDAZOLAM; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PREGABALIN; PRIMIDONE; TIAGABINE; TOPIRAMATE; VALPROATE SEMISODIUM; VALPROIC ACID; VIGABATRIN; VITAMIN K GROUP; ZONISAMIDE;

EID: 24344438982     PISSN: 14740338     EISSN: None     Source Type: Journal    
DOI: 10.1517/14740338.4.5.869     Document Type: Review
Times cited : (11)

References (49)
  • 1
    • 0030317076 scopus 로고    scopus 로고
    • Descriptive epidemiology of epilepsy: Contributions of population-based studies from Rochester, Minnesota
    • HAUSER WA, ANNEGERS JF, ROCCA WA: Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota. Mayo Clin. Proc. (1996) 71:576-586.
    • (1996) Mayo Clin. Proc. , vol.71 , pp. 576-586
    • Hauser, W.A.1    Annegers, J.F.2    Rocca, W.A.3
  • 2
    • 0026281619 scopus 로고
    • Parental epilepsy, anticonvulsant drugs, and reproductive outcome: Epidemiological and experimental findings spanning three decades; 2: Human studies
    • DANSKY LV, FINNELL LV: Parental epilepsy, anticonvulsant drugs, and reproductive outcome: epidemiological and experimental findings spanning three decades; 2: human studies. Reprod. Toxicol. (1991) 5:301-335.
    • (1991) Reprod. Toxicol. , vol.5 , pp. 301-335
    • Dansky, L.V.1    Finnell, L.V.2
  • 4
    • 0034675309 scopus 로고    scopus 로고
    • Population-based, prospective study of the care of women with epilepsy in pregnancy
    • FAIRGRIEVE SD, JACKSON M, JONAS P et al.: Population-based, prospective study of the care of women with epilepsy in pregnancy. Br. Med. J. (2000) 321:674-675.
    • (2000) Br. Med. J. , vol.321 , pp. 674-675
    • Fairgrieve, S.D.1    Jackson, M.2    Jonas, P.3
  • 5
    • 0029808810 scopus 로고    scopus 로고
    • The care of pregnant women with epilepsy - A survey of obstetricians in Scotland
    • RUSSELL AJ, MACPHERSON H, CAIRNIE V, BRODIE MJ: The care of pregnant women with epilepsy - a survey of obstetricians in Scotland. Seizure (1996) 5:271-277.
    • (1996) Seizure , vol.5 , pp. 271-277
    • Russell, A.J.1    Macpherson, H.2    Cairnie, V.3    Brodie, M.J.4
  • 6
    • 15244345581 scopus 로고    scopus 로고
    • Neuropsychological effects of exposure to anticonvulsant medication in utero
    • VINTEN J, ADAB N, KINI U, GORRY J, GREGG J, BAKER GA: Neuropsychological effects of exposure to anticonvulsant medication in utero. Neurology (2005) 64:949-953.
    • (2005) Neurology , vol.64 , pp. 949-953
    • Vinten, J.1    Adab, N.2    Kini, U.3    Gorry, J.4    Gregg, J.5    Baker, G.A.6
  • 7
    • 0023278721 scopus 로고
    • Strain differences in phenobarbital-induced teratogenesis in mice
    • FINNELL RH, SHIELDS HE, TAYLOR SM et al.: Strain differences in phenobarbital-induced teratogenesis in mice. Teratology (1987) 35:177-185
    • (1987) Teratology , vol.35 , pp. 177-185
    • Finnell, R.H.1    Shields, H.E.2    Taylor, S.M.3
  • 8
    • 0017331777 scopus 로고
    • Teratogenic activity and metabolism of primidone in the mouse
    • MCELHATTON PR, SULLIVAN FM, TOSELAND PA: Teratogenic activity and metabolism of primidone in the mouse. Epilepsia (1977) 18: 1-11.
    • (1977) Epilepsia , vol.18 , pp. 1-11
    • McElhatton, P.R.1    Sullivan, F.M.2    Toseland, P.A.3
  • 9
    • 2442554134 scopus 로고    scopus 로고
    • The AED (antiepileptic drug) pregnancy registry: A 6-year experience
    • HOLMES LB, WYSZYNSKI DF, LIEBERMAN E: The AED (antiepileptic drug) pregnancy registry: a 6-year experience. Arch. Neurol. (2004) 61:673-678.
    • (2004) Arch. Neurol. , vol.61 , pp. 673-678
    • Holmes, L.B.1    Wyszynski, D.F.2    Lieberman, E.3
  • 11
    • 33645609547 scopus 로고
    • Phenytoin embryopathy: Effect of epoxide hydrolase inhibitor on phenytoin exposure in utero in C57BL/6J mice
    • HARTSFIELD JK Jr, HOLMES LB, MOREL JG: Phenytoin embryopathy: effect of epoxide hydrolase inhibitor on phenytoin exposure in utero in C57BL/6J mice. Teratology (1983) 28:1-8.
    • (1983) Teratology , vol.28 , pp. 1-8
    • Hartsfield, J.K.1    Holmes, L.B.2    Morel, J.G.3
  • 12
    • 0026303466 scopus 로고
    • Parental epilepsy, anticonvulsant drugs, and reproductive outcome: Epidemiologic and experimental findings spanning three decades; 1: Animal studies
    • FINNELL RH, DANSKY LV: Parental epilepsy, anticonvulsant drugs, and reproductive outcome: epidemiologic and experimental findings spanning three decades; 1: Animal studies. Reprod. Toxicol. (1991) 5:281-299
    • (1991) Reprod. Toxicol. , vol.5 , pp. 281-299
    • Finnell, R.H.1    Dansky, L.V.2
  • 13
    • 0016537654 scopus 로고
    • Maternal Phenytoin ingestion and congenital abnormalities: Report of a case
    • HIRSCHBERGER M, KLEINBERG F. Maternal Phenytoin ingestion and congenital abnormalities: report of a case. Am. J. Dis. Child. (1975) 129:984.
    • (1975) Am. J. Dis. Child. , vol.129 , pp. 984
    • Hirschberger, M.1    Kleinberg, F.2
  • 14
    • 0033766475 scopus 로고    scopus 로고
    • Teratogenic effects of antiepileptic drugs: Use of an International Database on Malformations and Drug Exposure (MADRE)
    • ARPINO C, BRESCIANINI S, ROBERT E et al.: Teratogenic effects of antiepileptic drugs: use of an International Database on Malformations and Drug Exposure (MADRE). Epilepsia (2000) 41:1436-1443.
    • (2000) Epilepsia , vol.41 , pp. 1436-1443
    • Arpino, C.1    Brescianini, S.2    Robert, E.3
  • 15
    • 0016798512 scopus 로고
    • The fetal hydantoin syndrome
    • HANSON JW, SMITH DW: The fetal hydantoin syndrome. J. Pediatr. (1975) 87:285-290.
    • (1975) J. Pediatr. , vol.87 , pp. 285-290
    • Hanson, J.W.1    Smith, D.W.2
  • 16
    • 0026030573 scopus 로고
    • Spina bifida in infants of women treated with carbamazepine during pregnancy
    • ROSA FW: Spina bifida in infants of women treated with carbamazepine during pregnancy. N. Engl. J. Med. (1991) 324:674-677.
    • (1991) N. Engl. J. Med. , vol.324 , pp. 674-677
    • Rosa, F.W.1
  • 17
    • 0002764295 scopus 로고
    • Malformations and minor anomalies in children of epileptic mothers: Preliminary results of the prospective Helsinki study
    • Janz D, Dam M, Richens A, Bossi L Helge H and Schmidt D (Eds), Raven Press, NY, USA
    • GRANSTROM ML, HIILESMANN VK: Malformations and minor anomalies in children of epileptic mothers: preliminary results of the prospective Helsinki study. In: Epilepsy, Pregnancy and the Child. Janz D, Dam M, Richens A, Bossi L Helge H and Schmidt D (Eds), Raven Press, NY, USA (1992):251-258.
    • (1992) Epilepsy, Pregnancy and the Child , pp. 251-258
    • Granstrom, M.L.1    Hiilesmann, V.K.2
  • 18
    • 0035943105 scopus 로고    scopus 로고
    • Is carbamazepine teratogenic? A Prospective controlled study of 210 pregnancies
    • DIAV-CITRIN O, SHECHTMAN S, ARNON J, ORNOY A: Is carbamazepine teratogenic? A Prospective controlled study of 210 pregnancies. Neurology (2001) 57:321-324.
    • (2001) Neurology , vol.57 , pp. 321-324
    • Diav-Citrin, O.1    Shechtman, S.2    Arnon, J.3    Ornoy, A.4
  • 19
    • 14444288534 scopus 로고    scopus 로고
    • Maternal use of antiepileptic drugs and the risk of major congenital malformations: A joint European prospective study of human teratogenesis associated with maternal epilepsy
    • SAMREN EB, VAN DUIJN CM, KOCH S et al.: Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy. Epilepsia (1997) 38:981-990.
    • (1997) Epilepsia , vol.38 , pp. 981-990
    • Samren, E.B.1    Van Duijn, C.M.2    Koch, S.3
  • 20
    • 0037465533 scopus 로고    scopus 로고
    • Major malformations in offspring of women with epilepsy
    • KAAJA E, KAAJA R, HIILESMAA V: Major malformations in offspring of women with epilepsy. Neurology. (2003) 60:575-579.
    • (2003) Neurology , vol.60 , pp. 575-579
    • Kaaja, E.1    Kaaja, R.2    Hiilesmaa, V.3
  • 21
    • 0033968253 scopus 로고    scopus 로고
    • A mouse model for valproate teratogenicity: Parental effects, homeotic transformations, and altered HOX expression
    • FAIELLA A, WERNIG M, CONSALEZ GG et al.: A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression. Hum. Mol. Genet. (2000) 22:227-236.
    • (2000) Hum. Mol. Genet. , vol.22 , pp. 227-236
    • Faiella, A.1    Wernig, M.2    Consalez, G.G.3
  • 22
    • 0034959518 scopus 로고    scopus 로고
    • Repeated neural tube defects and valproate monotherapy suggest a pharmacogenetic abnormality
    • DUNCAN S, MERCHO S, LOPES-CENDES I et al.: Repeated neural tube defects and valproate monotherapy suggest a pharmacogenetic abnormality. Epilepsia (2001) 42:750-753.
    • (2001) Epilepsia , vol.42 , pp. 750-753
    • Duncan, S.1    Mercho, S.2    Lopes-Cendes, I.3
  • 23
    • 0037183488 scopus 로고    scopus 로고
    • Valproate embryopathy in three sets of siblings: Further proof of hereditary susceptibility
    • MALM H, KAJANTIE E, KIVIRIKKO S, KAARIAINEN H, PEIPPO M, SOMER M: Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility. Neurology. (2002) 59:630-633.
    • (2002) Neurology , vol.59 , pp. 630-633
    • Malm, H.1    Kajantie, E.2    Kivirikko, S.3    Kaariainen, H.4    Peippo, M.5    Somer, M.6
  • 24
    • 0026845320 scopus 로고
    • The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort
    • OMTZIGT JG, LOS FJ, GROBBEE DE et al.: The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort. Neurology (1992) 42(4 Suppl. 5):119-125.
    • (1992) Neurology , vol.42 , Issue.4 SUPPL. 5 , pp. 119-125
    • Omtzigt, J.G.1    Los, F.J.2    Grobbee, D.E.3
  • 25
    • 0026846163 scopus 로고
    • Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs
    • LINDHOUT D, OMTZIGT JG, CORNEL MC: Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs. Neurology (1992) 42(4 Suppl. 5):111-118.
    • (1992) Neurology , vol.42 , Issue.4 SUPPL. 5 , pp. 111-118
    • Lindhout, D.1    Omtzigt, J.G.2    Cornel, M.C.3
  • 26
    • 0026844611 scopus 로고
    • Major and minor birth malformations and antiepileptic drugs
    • KOCH S, LOSCHE G, JAGER-ROMAN E et al.: Major and minor birth malformations and antiepileptic drugs. Neurology (1992) 42(4 Suppl. 5):83-88.
    • (1992) Neurology , vol.42 , Issue.4 SUPPL. 5 , pp. 83-88
    • Koch, S.1    Losche, G.2    Jager-Roman, E.3
  • 27
    • 7444266950 scopus 로고    scopus 로고
    • Critical relationship between sodium valproate dose and human teratogenicity results of the Australian register of antiepileptic drugs in pregnancy
    • VAJDA FJ, O'BRIEN TJ, HITCHCOCK A et al.: Critical relationship between sodium valproate dose and human teratogenicity results of the Australian register of antiepileptic drugs in pregnancy. J. Clin. Neurosci. (2004) 11:854-8.
    • (2004) J. Clin. Neurosci. , vol.11 , pp. 854-858
    • Vajda, F.J.1    O'Brien, T.J.2    Hitchcock, A.3
  • 28
    • 2342617745 scopus 로고    scopus 로고
    • Sodium valproate and prescribing in pregnancy
    • Committee on Safety of Medicines
    • Committee on Safety of Medicines. Sodium valproate and prescribing in pregnancy. Current Problems in Pharmacovigilance (2003) 29:6.
    • (2003) Current Problems in Pharmacovigilance , vol.29 , pp. 6
  • 29
  • 31
    • 7244257375 scopus 로고    scopus 로고
    • The longer term outcome of children born to mothers with epilepsy
    • ADAB N, KINI U, VINTEN J et al.: The longer term outcome of children born to mothers with epilepsy. J. Neurol. Neurosurg. Psychiatry (2004) 75:1575-1583.
    • (2004) J. Neurol. Neurosurg. Psychiatry , vol.75 , pp. 1575-1583
    • Adab, N.1    Kini, U.2    Vinten, J.3
  • 32
    • 9144257236 scopus 로고    scopus 로고
    • Normal intelligence in children with prenatal exposure to carbamazepine
    • GAILY E, KANTOLA-SORSA E, HIILESMAA V et al.: Normal intelligence in children with prenatal exposure to carbamazepine. Neurology (2004) 13:28-32.
    • (2004) Neurology , vol.13 , pp. 28-32
    • Gaily, E.1    Kantola-Sorsa, E.2    Hiilesmaa, V.3
  • 33
    • 0030788657 scopus 로고    scopus 로고
    • Teratogenic effects of vigabatrin in TO mouse fetuses
    • ABDULRAZZAQ YM, BASTAKI SM, PADMANABHAN R: Teratogenic effects of vigabatrin in TO mouse fetuses. Teratology (1997) 55:165-176.
    • (1997) Teratology , vol.55 , pp. 165-176
    • Abdulrazzaq, Y.M.1    Bastaki, S.M.2    Padmanabhan, R.3
  • 34
    • 15244362235 scopus 로고    scopus 로고
    • Lamotrigine and the risk of malformations in pregnancy
    • CUNNINGTON M, TENNIS P: Lamotrigine and the risk of malformations in pregnancy. Neurology (2005) 64:955-960.
    • (2005) Neurology , vol.64 , pp. 955-960
    • Cunnington, M.1    Tennis, P.2
  • 35
    • 77957174599 scopus 로고
    • Developmental toxicity studies in mice, rats, and rabbits with the anticonvulsant gabapentin
    • PETRERE JA, ANDERSON JA: Developmental toxicity studies in mice, rats, and rabbits with the anticonvulsant gabapentin. Fundam. Appl. Toxicol. (1994) 23:585-589.
    • (1994) Fundam. Appl. Toxicol. , vol.23 , pp. 585-589
    • Petrere, J.A.1    Anderson, J.A.2
  • 36
    • 0141706894 scopus 로고    scopus 로고
    • Gabapentin exposure in human pregnancy: Results from the Gabapentin Pregnancy Registry
    • MONTOURIS G: Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry. Epilepsy Behav. (2003) 4:310-317.
    • (2003) Epilepsy Behav. , vol.4 , pp. 310-317
    • Montouris, G.1
  • 37
    • 0036712989 scopus 로고    scopus 로고
    • A postmarketing surveillance study of gabapentin as add-on therapy for 3,100 patients in England
    • WILTON LV, SHAKIR S: A postmarketing surveillance study of gabapentin as add-on therapy for 3,100 patients in England. Epilepsia (2002) 43:983-992.
    • (2002) Epilepsia , vol.43 , pp. 983-992
    • Wilton, L.V.1    Shakir, S.2
  • 38
    • 0033034045 scopus 로고    scopus 로고
    • Safety of tiagabine: Summary of 53 trials
    • LEPPIK IE, GRAM L, DEATON R et al.: Safety of tiagabine: summary of 53 trials. Epilepsy Res. (1999) 33:235-246.
    • (1999) Epilepsy Res. , vol.33 , pp. 235-246
    • Leppik, I.E.1    Gram, L.2    Deaton, R.3
  • 39
    • 0036799782 scopus 로고    scopus 로고
    • Topiramate kinetics during delivery, lactation, and in the neonate: Preliminary observations
    • OHMAN I, VITOLS S, LUEF G et al.: Topiramate kinetics during delivery, lactation, and in the neonate: preliminary observations. Epilepsia (2002) 43:1157-1160.
    • (2002) Epilepsia , vol.43 , pp. 1157-1160
    • Ohman, I.1    Vitols, S.2    Luef, G.3
  • 40
    • 0030426706 scopus 로고    scopus 로고
    • Teratogenicity of carbamazepine-10, 11-epoxide and oxcarbazepine in the SWV mouse
    • BENNETT GD, AMORE BM, FINNELL RH et al.: Teratogenicity of carbamazepine-10, 11-epoxide and oxcarbazepine in the SWV mouse. Pharmacol. Exp. Ther. (1996) 279:1237-1242.
    • (1996) Pharmacol. Exp. Ther. , vol.279 , pp. 1237-1242
    • Bennett, G.D.1    Amore, B.M.2    Finnell, R.H.3
  • 41
    • 1842788174 scopus 로고    scopus 로고
    • Oxcarbazepine in pregnancy, clinical experience in Argentina
    • MEISCHENGUISER R, D'GIONO CH, FERRARO SM: Oxcarbazepine in pregnancy, clinical experience in Argentina. Epilepsy Behav. (2004) 5:163-167.
    • (2004) Epilepsy Behav. , vol.5 , pp. 163-167
    • Meischenguiser, R.1    D'Giono, C.H.2    Ferraro, S.M.3
  • 42
    • 0142040806 scopus 로고    scopus 로고
    • Developmental outcome of levetiracetam, its major metabolite in humans, 2-pyrrolidinone N-butyric acid, and its enantiomer (R)-alpha-ethyl-oxopyrrolidine acetamide in a mouse model of teratogenicity
    • ISOHERRANEN N, SPIEGELSTEIN O, BIALER M et al.: Developmental outcome of levetiracetam, its major metabolite in humans, 2-pyrrolidinone N-butyric acid, and its enantiomer (R)-alpha-ethyl-oxopyrrolidine acetamide in a mouse model of teratogenicity. Epilepsia (2003) 44:1280-1288
    • (2003) Epilepsia , vol.44 , pp. 1280-1288
    • Isoherranen, N.1    Spiegelstein, O.2    Bialer, M.3
  • 43
    • 0042420527 scopus 로고    scopus 로고
    • Levetiracetam monotherapy during pregnancy: A case series
    • LONG L: Levetiracetam monotherapy during pregnancy: a case series. Epilepsy Behav. (2003) 4:447-448.
    • (2003) Epilepsy Behav. , vol.4 , pp. 447-448
    • Long, L.1
  • 44
    • 33645611267 scopus 로고    scopus 로고
    • Leveciracetam therapy in human pregnancy: Preliminary experience from The UK Epilepsy and Pregnancy Register
    • 26th IBE/ILAE International Epilepsy Congress. Paris, France
    • HUNT SJ, CRAIG JJ, IRWIN B et al.: Leveciracetam therapy in human pregnancy: preliminary experience from The UK Epilepsy and Pregnancy Register. 26th IBE/ILAE International Epilepsy Congress. Paris, France (2005).
    • (2005)
    • Hunt, S.J.1    Craig, J.J.2    Irwin, B.3
  • 45
    • 0029807973 scopus 로고    scopus 로고
    • Preliminary report on teratogenic effects of zonisamide in the offspring of treated women with epilepsy
    • KONDO T, KANEKO S, AMANO Y et al.: Preliminary report on teratogenic effects of zonisamide in the offspring of treated women with epilepsy. Epilepsia (1996) 37:1242-1244.
    • (1996) Epilepsia , vol.37 , pp. 1242-1244
    • Kondo, T.1    Kaneko, S.2    Amano, Y.3
  • 46
    • 7044241277 scopus 로고    scopus 로고
    • Safety of zonisamide therapy: Prospective follow-up survey
    • OHTAHARA S, YAMATOGI Y: Safety of zonisamide therapy: prospective follow-up survey. Seizure (2004) 13 (Suppl. 1):S50-S55
    • (2004) Seizure , vol.13 , Issue.SUPPL. 1
    • Ohtahara, S.1    Yamatogi, Y.2
  • 47
    • 0028299243 scopus 로고
    • Epilepsy and pregnancy: A prospective study of seizure control in relation to free and total plasma concentrations of carbamazepine and phenytoin
    • TOMSON T, LINDBOM U, EKQVIST B et al.: Epilepsy and pregnancy: a prospective study of seizure control in relation to free and total plasma concentrations of carbamazepine and phenytoin. Epilepsia (1994) 35:122-130.
    • (1994) Epilepsia , vol.35 , pp. 122-130
    • Tomson, T.1    Lindbom, U.2    Ekqvist, B.3
  • 49
    • 2342422000 scopus 로고    scopus 로고
    • Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants?
    • CHOULIKA S, GRABOWSKI E, HOLMES LB: Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants? Am. J. Obstet. Gynecol. (2004) 190:882-883.
    • (2004) Am. J. Obstet. Gynecol. , vol.190 , pp. 882-883
    • Choulika, S.1    Grabowski, E.2    Holmes, L.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.