Ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis: A role for the tumor necrosis factor signaling axis

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 8, 2005, Pages 1466-1472

  Wahl, Elizabeth C ^b   Perrien, Daniel S ^b   Aronson, James ^a,b   Liu, Zhendong ^b   Fletcher, Terry W ^a   Skinner, Robert A ^a   Feige, Ulrich ^c   Suva, Larry J ^a   Badger, Thomas M ^a   Lumpkin Jr , Charles K ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b ARKANSAS CHILDREN S HOSPITAL RESEARCH INSTITUTE   (United States)

^c AMGEN INC   (United States)

Author keywords

Chronic Alcohol; Chronic Ethanol; Distraction Osteogenesis; Interleukin 1; Tumor Necrosis Factor

Indexed keywords

ALCOHOL; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; MACROGOL; RECOMBINANT INTERLEUKIN 1; RECOMBINANT TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISTRACTION OSTEOGENESIS; DOSE RESPONSE; FIBROBLAST; FRACTURE EXTERNAL FIXATION; INFLAMMATORY CELL; LEG LENGTHENING; MALE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TIBIA FRACTURE;

ALCOHOLISM; ANIMALS; BONE REGENERATION; ETHANOL; INTERLEUKIN-1; MALE; OSTEOGENESIS, DISTRACTION; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 24144502492     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.alc.0000174695.09579.11     Document Type: Article

References (36)

1. Aronson J (1994) Experimental and clinical experience with distraction osteogenesis. Cleft Palate Craniofac J 31:473-481; discussion 481-482.
2. Aronson J, Gao GG, Shen XC, McLaren SG, Skinner RA, Badger TM, Lumpkin Jr, CK (2001) The effect of aging on distraction osteogenesis in the rat. J Orthop Res 19:421-427.
3. Aronson J, Liu L, Liu Z, Gao GG, Perrien D, Brown E, Skinner RA, Thomas JR, Morris KD, Suva LJ, Badger TM, Lumpkin Jr, CK (2002) Decreased endosteal membranous bone formation accompanies aging in a mouse model of distraction osteogenesis. E-biomed, Journal of Regenerative Medicine 3:7-15.
4. Aronson J, Shen XC, Skinner RA, Hogue WR, Badger TM, Lumpkin Jr CK (1997) Rat model of distraction osteogenesis. J Orthop Res 15:221-226.
5. Badger TM, Ronis MJ, Lumpkin CK, Valentine CR, Shahare M, Irby D, Huang J, Mercado C, Thomas P, Ingelman-Sundberg M, Crouch J (1993) Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome p450 isozymes of the rat. J Pharmacol Exp Ther 264:438-447.
6. Bertolini DR, Nedwin GE, Bringman TS, Smith DD, Mundy GR (1986) Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature 319:516-518.
7. Brown EC, Perrien DS, Fletcher TW, Irby DJ, Aronson J, Gao GG, Hogue WJ, Skinner RA, Suva LJ, Ronis MJ, Hakkak R, Badger TM, Lumpkin Jr CK (2002) Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition. J Pharmacol Exp Ther 301:1132-1138.
8. Coxon A, Bolon B, Estrada J, Kaufman S, Scully S, Rattan A, Duryea D, Hu YL, Rex K, Pacheco E, Van G, Zack D, Feige U (2002) Inhibition of interleukin-1 but not tumor necrosis factor suppresses neovascularization in rat models of corneal angiogenesis and adjuvant arthritis. Arthritis Rheum 46:2604-2612.
9. Crilly RG, Anderson C, Hogan D, Delaquerriere-Richardson L (1988) Bone histomorphometry, bone mass, and related parameters in alcoholic males. Calcif Tissue Int 43:269-276.
10. Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA (1994) A lymphotoxin-beta-specific receptor [comment]. Science 264:707-710.
11. Demis E, Roux C, Breban M, Dougados M (2002) Infliximab in spondylarthropathy-influence on bone density. Clin Exp Rheumatol 20:S185-S186.
12. Dinarello CA (2002) The IL-1 family and inflammatory diseases. Clin Exp Rheumatol 20:S1-S13.
13. Fang C, Lindros KO, Badger TM, Ronis MJ, Ingelman-Sundberg M (1998) Zonated expression of cytokines in rat liver: Effect of chronic ethanol and the cytochrome p450 2c1 inhibitor, chlormethiazole. Hepatology 27:1304-1310.
14. Feige U, Hu YL, Gasser J, Campagnuolo G, Munyakazi L, Bolon B (2000) Anti-interleukin-1 and anti-tumor necrosis factor-alpha synergistically inhibit adjuvant arthritis in Lewis rats. Cell Mol Life Sci 57:1457-1470.
15. Frost A, Jonsson KB, Nilsson O, Ljunggren O (1997) Inflammatory cytokines regulate proliferation of cultured human osteoblasts. Acta Orthop Scand 68:91-96.
16. Fujii T, Sato K, Ozawa M, Kasono K, Imamura H, Kanaji Y, Tsushima T, Shizume K (1989) Effect of interleukin-1 (IL-1) on thyroid hormone metabolism in mice: Stimulation by IL-1 of iodothyronine 5′-deiodinating activity (type i) in the liver. Endocrinology 124:167-174.
17. Gerstenfeld LC, Cho TJ, Kon T, Aizawa T, Cruceta J, Graves BD, Einhorn TA (2001) Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling. Cells Tissues Organs 169:285-294.
18. Jee WSS (1991) The aged rat model for bone biology studies: Foreword. Cells and Materials Supplement 1:1-3.
19. Kimble RB, Matayoshi AB, Vannice JL, Kung VT, Williams C, Pacifici R (1995) Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period. Endocrinology 136:3054-3061.
20. Lumpkin Jr, CK Aronson J, Shen XC, Gao GG, Skinner RA, Badger TM (1996) The impact of total enteral nutrition on distraction osteogenesis in a rat model. J Bone Miner Res 11:962-969.
21. Ma T, Miyanishi K, Trindade MC, Genovese M, Regula D, Smith RL, Goodman SB (2003) Interleukin 1 receptor antagonist inhibits localized bone formation in vivo. J Rheumatol 30:2547-2552.
22. Nanes MS (2003) Tumor necrosis factor-alpha: Molecular and cellular mechanisms in skeletal pathology. Gene 321:1-15.
23. Nguyen L, Dewhirst FE, Hauschka PV, Stashenko P (1991) Interleukin-1 beta stimulates bone resorption and inhibits bone formation in vivo. Lymphokine Cytokine Res 10:15-21.
24. Ozawa M, Sato K, Han DC, Kawakami M, Tsushima T, Shizume K (1988) Effects of tumor necrosis factor-alpha/cachectin on thyroid hormone metabolism in mice. Endocrinology 123:1461-1467.
25. Perrien DS, Brown EC, Fletcher TW, Irby DJ, Aronson J, Gao GG, Skinner RA, Hogue WR, Feige U, Suva U, Ronis MJ, Badger TM, Lumpkin Jr CK (2002) Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis. J Pharmacol Exp Ther 303:904-908.
26. Perrien DS, Liu Z, Wahl EC, Bunn RC, Skinner RA, Aronson J, Fowlkes J, Badger TM, Lumpkin Jr CK (2003) Chronic ethanol exposure is associated with a local increase in TNF-alpha and decreased proliferation in the rat distraction gap. Cytokine 23:179-189.
27. Purohit V (1997) Introduction to the alcohol and osteoporosis symposium. Alcohol Clin Exp Res 21:383-384.
28. Ronis MJ, Aronson J, Gao GG, Hogue W, Skinner RA, Badger TM, Lumpkin Jr CK (2001) Skeletal effects of developmental lead exposure in rats. Toxicol Sci 62:321-329.
29. Sampson HW (1998) Effect of alcohol consumption on adult and aged bone: A histomorphometric study of the rat animal model. Alcohol Clin Exp Res 22:2029-2034.
30. Skinner RA, Hickman SG, Nelson CL, Germer RA (1992) Modified stain for identification of Staphylococcus aureus in osteomyelitis. J Histotechnol 15:303-306.
31. Skinner RA, Hickmon SG, Lumpkin Jr, CK Aronson J, Nicholas RW (1997) Decalcified bone: Twenty years of successful specimen management. J Histotechnol 16:765-773.
32. Tay BK, Le AX, Gould SE, Helms JA (1998) Histochemical and molecular analyses of distraction osteogenesis in a mouse model. J Orthop Res 16:636-642.
33. Turner RT, Wronski TJ, Zhang M, Kidder LS, Bloomfield SA, Sibonga JD (1998) Effects of ethanol on gene expression in rat bone: Transient dose-dependent changes in mRNA levels for matrix proteins, skeletal growth factors, and cytokines are followed by reductions in bone formation. Alcohol Clin Exp Res 22:1591-1599.
34. Ueng SW, Lin SS, Wang CR, Liu SJ, Tai CL, Shih CH (1999) Bone healing of tibial lengthening is delayed by cigarette smoking: Study of bone mineral density and torsional strength on rabbits. J Trauma 46:110-115.
35. Voronov E, Shouval DS, Krelin Y, Cagnano E, Benharroch D, Iwakura Y, Dinarello CA, Apte RN (2003) IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci USA 100:2645-2650.
36. Wennberg P, Nordstrom P, Lorentzon R, Lerner UH, Lorentzon M (2002) TNF-alpha gene polymorphism and plasma TNF-alpha levels are related to lumbar spine bone area in healthy female Caucasian adolescents. Eur J Endocrinol 146:629-634.