Acute cardiac toxicity associated with high-dose intravenous methotrexate therapy: Case report and review of the literature

Pharmacotherapy

Volumn 25, Issue 9, 2005, Pages 1271-1276

  Perez Verdia, Alejandro ^a   Angulo, Freddy ^a   Hardwicke, Fred L ^a   Nugent, Kenneth M ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Arrhythmia; Cardiac toxicity; High dose methotrexate

Indexed keywords

ACICLOVIR; ADENOSINE; ALPRAZOLAM; AMINOPHYLLINE; CISPLATIN; DEXAMETHASONE; DOXORUBICIN; ENOXAPARIN; ETHINYLESTRADIOL; FOLINIC ACID; LEVOFLOXACIN; LORAZEPAM; MAGNESIUM SULFATE; MANNITOL; METHOTREXATE; MULTIVITAMIN; ONDANSETRON; PANTOPRAZOLE; POTASSIUM CHLORIDE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; SCOPOLAMINE; SERTRALINE; WARFARIN; ZOLPIDEM;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; BRADYCARDIA; CANCER CHEMOTHERAPY; CARDIOTOXICITY; CASE REPORT; CHEMOTHERAPY INDUCED EMESIS; DEATH; DRUG MEGADOSE; ELECTROCARDIOGRAM; FEMALE; HEART ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; MALE; METASTASIS; NEUROTOXICITY; NONHUMAN; OSTEOSARCOMA; PREOPERATIVE TREATMENT; PSORIASIS; REVIEW; RHEUMATOID ARTHRITIS; SUPRAVENTRICULAR PREMATURE BEAT; SURVIVAL RATE; TREATMENT OUTCOME; TWO DIMENSIONAL ECHOCARDIOGRAPHY;

ADULT; ANTIMETABOLITES, ANTINEOPLASTIC; BRADYCARDIA; ELECTROCARDIOGRAPHY; FATAL OUTCOME; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; LEUCOVORIN; METHOTREXATE; OSTEOSARCOMA; SPINAL NEOPLASMS; TACHYCARDIA, VENTRICULAR; VITAMIN B COMPLEX;

EID: 24144494246     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.2005.25.9.1271     Document Type: Review

References (14)

1. Vezmar S, Becker A, Bode U, et al. Biochemical and clinical aspects of methotrexate neurotoxicity. Chemotherapy 2003;49:92-104.
2. Quinn CT, Kamen BA. A biochemical perspective of methotrexate neurotoxicity with insight on nonfolate rescue modalities. J Invest Med 1996;44:522-30.
3. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-45.
4. Kettunen R, Huikuri HV, Oikarinen A, et al. Methotrexate-linked ventricular arrhythmias. Acta Derm Venereol 1995;75:391-2.
5. Borek G, Jenzer HR, Frey LD, et al. Repetitive exercise induced ventricular tachycardia in a patient with rheumatoid arthritis taking low dose methotrexate. J Rheumatol 1992;19:1004-5.
6. Gasser AB, Tieche M, Bronner KW. Neurologic and cardiotoxicity following IV application of methotrexate. Cancer Treat Rep 1982;66:1561-2.
7. Walker RW, Allen JC, Rosen G, et al. Transient cerebral dysfunction secondary to high-dose methotrexate. J Clin Oncol 1986;4:1845-50.
8. Jaffe N, Takaue Y, Takashi A, et al. Transient neurologic disturbances induced by high-dose methotrexate treatment. Cancer 1985;56:1356-60.
9. Lien HH, Blomlie V, Saeter G, et al. Osteogenic sarcoma: MR signal abnormalities of the brain in asymptomatic patients treated with high-dose methotrexate. Radiology 1991;179:547-50.
10. Mallet ML. Proarrhythmic effects of adenosine: a review of the literature. Emerg Med J 2004;21:408-10.
11. Welch GN, Loscalzo J. Homocysteine and artherothrombosis. N Engl J Med 1998;338:1042-50.
12. Nakayama DK, Geller DA, Di Silvio M, et al. Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle. Am J Physiol 1994;266:L455-60.
13. Phillips PC, Thaler HT, Allen JC, et al. High-dose leucovorin reverses acute high-dose methotrexate neurotoxicity in the rat. Ann Neurol 1989;25:365-72.
14. Fuskevag OM, Kristiansen C, Lindal S, et al. Leucovorin and maximum tolerated dose toxicity of methotrexate in rats. Pediatric Hematol Oncol 2000;17:651-8.