Real-time Raman system for in vivo disease diagnosis

Journal of Biomedical Optics

Volumn 10, Issue 3, 2005, Pages

  Motz, Jason T ^a   Gandhi, Saumil J ^a   Scepanovic, Obrad R ^a   Haka, Abigail S ^a   Kramer, John R ^a   Dasari, Ramachandra R ^a   Feld, Michael S ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Atherosclerosis; Breast cancer; In vivo Raman spectroscopy; Raman probes; Real time diagnosis

Indexed keywords

GLASS FIBER;

ALGORITHM; ANIMAL; ARTERIOSCLEROSIS; ARTICLE; ARTIFICIAL INTELLIGENCE; BREAST TUMOR; COMPUTER ASSISTED DIAGNOSIS; COMPUTER INTERFACE; COMPUTER PROGRAM; COMPUTER SYSTEM; EQUIPMENT; EVALUATION STUDY; FIBER OPTICS; HUMAN; METHODOLOGY; RAMAN SPECTROMETRY; EVALUATION; INSTRUMENTATION;

ALGORITHMS; ANIMALS; ARTERIOSCLEROSIS; ARTIFICIAL INTELLIGENCE; BREAST NEOPLASMS; COMPUTER SYSTEMS; DIAGNOSIS, COMPUTER-ASSISTED; FIBER OPTIC TECHNOLOGY; HUMANS; OPTICAL FIBERS; SOFTWARE; SPECTRUM ANALYSIS, RAMAN; USER-COMPUTER INTERFACE; FIBER OPTICS;

BIOCHEMISTRY; DIAGNOSIS; DISEASES; ONCOLOGY; OPTICAL SYSTEMS; RAMAN SPECTROSCOPY; SURGERY; TISSUE;

ATHEROSCLEROSIS; BREAST CANCER; DISEASE DIAGNOSIS; OPTICAL FIBER RAMAN PROBES; REAL-TIME RAMAN SYSTEM; TISSUE ANALYSIS;

BIOMEDICAL ENGINEERING;

EID: 24144484885     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.1920247     Document Type: Article

References (27)

1. A. Mahadevan-Jansen and R. Richards-Kortum, "Raman spectroscopy for the detection of cancers and precancers," J. Biomed. Opt. 1(1), 31-70 (1996). (Pubitemid 126646134)
2. E. B. Hanlon, R. Manoharan, T. W. Koo, K. E. Shafer, J. T. Motz, M. Fitzmaurice, J. R. Kramer, I. Itzkan, R. R. Dasari, and M. S. Feld, "Prospects for in vivo Raman spectroscopy," Phys. Med. Biol. 45(2), R1-R59 (2000). (Pubitemid 30096760)
3. H. P. Buschman, G. Deinum, J. T. Motz, M. Fitzmaurice, J. R. Kramer, A. van der Laarse, A. V. Bruschke, and M. S. Feld, "Raman microspectroscopy of human coronary atherosclerosis: biochemical assessment of cellular and extracellular morphologic structures in situ," Cardiovasc. Pathol. 10(2), 69-82 (2001). (Pubitemid 32577386)
4. H. P. Buschman, J. T. Motz, G. Deinum, T. J. Römer, M. Fitzmaurice, J. R. Kramer, A. van der Laarse, A. V. Bruschke, and M. S. Feld, "Diagnosis of human coronary atherosclerosis by morphology-based Raman spectroscopy," Cardiovasc. Pathol. 10(2), 59-68 (2001). (Pubitemid 32577385)
5. M. Gniadecka, O. F. Nielsen, D. H. Christensen, and H. C. Wulf, "Structure of water, proteins, and lipids in intact human skin, hair, and nail," J. Invest. Dermatol. 110(4), 393-398 (1998). (Pubitemid 28158656)
6. A. S. Haka, K. E. Shafer-Peltier, M. Fitzmaurice, J. Crowe, R. R. Dasari, and M. S. Feld, "Identifying microcalcifications in benign and malignant breast lesions by probing differences in their chemical composition using Raman spectroscopy," Cancer Res. 62(18), 5375-5380 (2002). (Pubitemid 35024616)
7. A. M. K. Enejder, T. W. Koo, J. Oh, M. Hunter, S. Sasic, M. S. Feld, and G. L. Horowitz, "Blood analysis by Raman spectroscopy," Opt. Lett. 27(22), 2004-2006 (2002).
8. R. R. Alfano, C. H. Liu, W. L. Sha, H. R. Zhu, D. L. Akins, J. Cleary, R. Prudente, and E. Cellmer, "Human breast tissues studied by IR Fourier transform Raman spectroscopy," Lasers Life Sci. 4(1), 23-28 (1991).
9. C. J. Frank, R. L. McCreery, and D. C. B. Redd, "Raman spectroscopy of normal and diseased human breast tissues," Anal. Chem. 67(5), 777-783 (1995).
10. R. Manoharan, K. Shafer, L. Perelman, J. Wu, K. Chen, G. Deinum, M. Fitzmaurice, J. Myles, J. Crowe, R. R. Dasari, and M. S. Feld, "Raman spectroscopy and fluorescence photon migration for breast cancer diagnosis and imaging," Photochem. Photobiol. 67(1), 15-22 (1998). (Pubitemid 128471956)
11. P. Crow, N. Stone, C. A. Kendall, J. S. Uff, J. A. M. Farmer, H. Barr, and M. P. J. Wright, "The use of Raman spectroscopy to identify and grade prostatic adenocarcinoma in vitro," Br. J. Cancer 89(1), 106-108 (2003). (Pubitemid 36897944)
12. P. J. Caspers, G. W Lucassen, R. Wolthuis, H. A. Bruining, and G. J. Puppels, "In vitro and in vivo Raman spectroscopy of human skin," Biospectroscopy 4(5 Suppl), S31-S39 (1998). (Pubitemid 128757802)
13. P. J. Caspers, G. W Lucassen, H. A. Bruining, and G. J. Puppels, "Automated depth-scanning confocal Raman microspectrometer for rapid in vivo determination of water concentration profiles in human skin," J. Raman Spectrosc. 31(8-9), 813-818 (2000).
14. T. R. Hata, T. A. Scholz, I. V. Ermakov, R. W McClane, F. Khachik, W. Gellermann, and L. K. Pershing, "Non-invasive Raman spectroscopic detection of carotenoids in human skin," J. Invest. Dermatol. 115(3), 441-448 (2000).
15. U. Utzinger, D. L. Heintzelman, A. Mahadevan-Jansen, A. Malpica, M. Follen, and R. Richards-Kortum, "Near-infrared Raman spectroscopy for in vivo detection of cervical precancers," Appl. Spectrosc. 55(8), 955-959 (2001). (Pubitemid 32936269)
16. H. P. Buschman, E. T. Marple, M. L. Wach, B. Bennett, T. C. Schut, H. A. Bruining, A. V. Bruschke, A. van der Laarse, and G. J. Puppels, "In vivo determination of the molecular composition of artery wall by intravascular Raman spectroscopy," Anal. Chem. 72(16), 3771-3775 (2000). (Pubitemid 30646514)
17. T. C. Bakker Schut, M. J. H. Witjes, H. J. C. M. Sterenborg, O. C. Speelman, J. L. N. Roodenburg, E. T. Marple, H. A. Bruining, and G J. Puppels, "In vivo detection of dysplastic tissue by Raman spectroscopy," Anal. Chem. 72(24), 6010-6018 (2000). (Pubitemid 32002679)
18. M. G. Shim, L. M. Song, N. E. Marcon, and B. C. Wilson, "In vivo near-infrared Raman spectroscopy: demonstration of feasibility during clinical gastrointestinal endoscopy," Photochem. Photobiol. 72(1), 146-150 (2000).
19. J. T. Motz, M. Hunter, L. H. Galindo, J. A. Gardecki, J. R. Kramer, R. R. Dasari, and M. S. Feld, "Optical fiber probe for biomedical Raman spectroscopy," Appl. Opt. 43(3), 542-554 (2004).
20. J. T. Motz, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, M. Fitzmaurice, R. R. Dasari, J. R. Kramer, and M. S. Feld, "In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque," Submitted (2005).
21. T. C. Bakker Schut, R. Wolthuis, P. J. Caspers, and G. J. Puppels, "Real-time tissue characterization on the basis of in vivo Raman spectra," J. Raman Spectrosc. 33(7), 580-585 (2002).
22. K. E. Shafer-Peltier, A. S. Haka, M. Fitzmaurice, J. Crowe, J. Myles, R. R. Dasari, and M. S. Feld, "Raman microspectroscopic model of human breast tissue: implications for breast cancer diagnosis in vivo," J. Raman Spectrosc. 33(7), 552-563 (2002).
23. A. S. Haka, K. E. Shafer-Peltier, M. Fitzmaurice, J. Crowe, R. R. Dasari, and M. S. Feld, "Detecting breast cancer using Raman spectroscopy," Submitted (2005).
24. J. F. Brennan, Y. Wang, R. R. Dasari, and M. S. Feld, "Near-infrared Raman spectrometer systems for human tissue studies," Appl. Spectrosc. 51(2), 201-208 (1997). (Pubitemid 127613820)
25. M. G. Shim and B. C. Wilson, "Development of an in vivo Raman spectroscopic system for diagnostic applications," J. Raman Spectrosc. 28(2-3), 131-142 (1997). (Pubitemid 127693372)
26. G. J. Puppels, T. C. Bakker Schut, P. J. Caspers, R. Wolthuis, M. van Aken, A. van der Laarse, H. A. Bruining, H. P. J. Buschman, M. G Shim, and B. C. Wilson, "In Vivo Raman Spectroscopy," in Handbook of Raman Spectroscopy, I. R. Lewis and H. G. M. Edwards, Eds., pp. 549-574, Dekker, New York (2001).
27. J. T. Motz, Development of in vivo Raman spectroscopy of atherosclerosis, PhD thesis, Massachusetts Institute of Technology, Cambridge (2003).