Male sex aggravates the phenotype in mouse models of hypertrophic cardiomyopathy

Herz

Volumn 30, Issue 5, 2005, Pages 405-408

  Maass, Alexander H ^a   Maier, Sebastian K G ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Arrhythmia; Fibrosis; Hypertrophy; Myosin heavy chain; Sudden cardiac death; Troponin T

Indexed keywords

MYOSIN HEAVY CHAIN; TROPONIN T;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FEMALE; HYPERTROPHIC CARDIOMYOPATHY; MALE; MORTALITY; MOUSE; MUTATION; NONHUMAN; PHENOTYPE; STRESS; SYSTOLE; TRANSGENIC MOUSE;

EID: 24144473918     PISSN: 03409937     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00059-005-2710-9     Document Type: Article

References (19)

1. Bonne G, Carrier L, Richard P, et al. Familial hypertrophic cardiomyopathy: from mutations to functional defects. Circ Res 1998;83:580-93.
2. Freeman K, Lerman I, Kranias EG, et al. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. J Clin Invest 2001;107:967-74.
3. Konhilas JP, Maass AH, Luckey SW, et al. Sex modifies exercise and cardiac adaptation in mice. Am J Physiol Heart Circ Physiol 2004;287:H2768-76.
4. Leinwand LA. Sex is a potent modifier of the cardiovascular system. J Clin Invest 2003;112:302-7.
5. Maass AH, Ikeda K, Oberdorf-Maass S, et al. Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T. Circulation 2004;110:2102-9.
6. Maron BJ. Hypertrophic cardiomyopathy. Lancet 1997;350:127-33.
7. Maron BJ, Gardin JM, Flack JM, et al. Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults. Circulation 1995;92:785-9.
8. Maron BJ, Shirani J, Poliac LC, et al. Sudden death in young competitive athletes. Clinical, demographic, and pathological profiles. JAMA 1996;276:199-204.
9. Olsson MC, Palmer BM, Leinwand LA, et al. Gender and aging in a transgenic mouse model of hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol 2001;280:H1136-44.
10. Peters RW ,Gold MR. The influence of gender on arrhythmias. Cardiol Rev 2004;12:97-105.
11. Roberts R, Sigwart U. New concepts in hypertrophic cardiomyopathies, part I. Circulation 2001;104:2113-6.
12. Roberts R, Sigwart U. New concepts in hypertrophic cardiomyopathies, part II. Circulation 2001;104:2249-52.
13. Semsarian C, Healey MJ, Fatkin D, et al. A polymorphic modifier gene alters the hypertrophic response in a murine model of familial hypertrophic cardiomyopathy. J Mol Cell Cardiol 2001;33:2055-60.
14. Suzuki M, Carlson KM, Marchuk DA, et al. Genetic modifier loci affecting survival and cardiacfunction in murine dilated cardiomyopathy. Circulation 2002;105:1824-9.
15. Tardiff JC, Factor SM, Tompkins BD, et al. A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. J Clin Invest 1998;101:2800-11.
16. Tardiff JC, Hewett TE, Palmer BM, et al. Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. J Clin Invest 1999;104:469-81.
17. Varnava AM, Elliott PM, Baboonian C, et al. Hypertrophic cardiomyopathy: histopathological features of sudden death in cardiac troponin T disease. Circulation 2001;104:1380-4.
18. Vikstrom KL, Factor SM ,Leinwand LA. Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy. Mol Med 1996;2:556-67.
19. Wigle ED, Rakowski H, Kimball BP, et al. Hypertrophic cardiomyopathy. Clinical spectrum and treatment. Circulation 1995;92:1680-92.