-
1
-
-
0025678601
-
Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients
-
KOLB HJ, MITTERMULLER J, CLEMM C et al.: Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood (1990) 76(12):2462-2465.
-
(1990)
Blood
, vol.76
, Issue.12
, pp. 2462-2465
-
-
Kolb, H.J.1
Mittermuller, J.2
Clemm, C.3
-
2
-
-
0026322151
-
A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
-
VAN DER BRUGGEN P, TRAVERSARI C, CHOMEZ P et al.: A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science (1991) 254(5038):1643-1647. First report of a human CTL-recognised TAA.
-
(1991)
Science
, vol.254
, Issue.5038
, pp. 1643-1647
-
-
Van Der Bruggen, P.1
Traversari, C.2
Chomez, P.3
-
4
-
-
0027405374
-
Identification of two cytotoxic T lymphocyte-recognized epitopes in the Ras protein
-
SKIPPER J, STAUSS HJ: Identification of two cytotoxic T lymphocyte-recognized epitopes in the Ras protein. J. Exp. Med. (1993) 177(5):1493-1498.
-
(1993)
J. Exp. Med.
, vol.177
, Issue.5
, pp. 1493-1498
-
-
Skipper, J.1
Stauss, H.J.2
-
5
-
-
0035892131
-
Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein
-
CLARK RE, DODI IA, HILL SC et al.: Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein. Blood (2001) 98(10):2887-2893.
-
(2001)
Blood
, vol.98
, Issue.10
, pp. 2887-2893
-
-
Clark, R.E.1
Dodi, I.A.2
Hill, S.C.3
-
6
-
-
0033819308
-
Immunization of cancer patients with autologous cancer-derived heat shock protein gp96 preparations: A pilot study
-
JANETZKI S, PALLA D, ROSENHAUER V et al.: Immunization of cancer patients with autologous cancer-derived heat shock protein gp96 preparations: a pilot study. Int. J. Cancer (2000) 88(2):232-238.
-
(2000)
Int. J. Cancer
, vol.88
, Issue.2
, pp. 232-238
-
-
Janetzki, S.1
Palla, D.2
Rosenhauer, V.3
-
7
-
-
12144290005
-
Heat shock proteins: Biological functions and clinical application as personalized vaccines for human cancer
-
CASTELLI C, RIVOLTINI L, RINI F et al.: Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer. Cancer Immunol. Immunother. (2004) 53:227-233.
-
(2004)
Cancer Immunol. Immunother.
, vol.53
, pp. 227-233
-
-
Castelli, C.1
Rivoltini, L.2
Rini, F.3
-
8
-
-
2642683198
-
Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: Definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes
-
JAGER E, CHEN YT, DRIJFHOUT JW et al.: Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J. Exp. Med. (1998) 187(2):265-270.
-
(1998)
J. Exp. Med.
, vol.187
, Issue.2
, pp. 265-270
-
-
Jager, E.1
Chen, Y.T.2
Drijfhout, J.W.3
-
9
-
-
0035902080
-
Progress in human tumour immunology and immunotherapy
-
ROSENBERG SA: Progress in human tumour immunology and immunotherapy. Nature (2001) 411(6835):380-384.
-
(2001)
Nature
, vol.411
, Issue.6835
, pp. 380-384
-
-
Rosenberg, S.A.1
-
10
-
-
0028316911
-
Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor
-
KAWAKAMI Y, ELIYAHU S, DELGADO CH et al.: Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc. Natl. Acad. Sci. USA (1994) 91(9):3515-3519.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, Issue.9
, pp. 3515-3519
-
-
Kawakami, Y.1
Eliyahu, S.2
Delgado, C.H.3
-
11
-
-
0030769148
-
Tumor eradication by wild-type p53-specific cytotoxic T lymphocytes
-
VIERBOOM MP, NIJMAN HW, OFFRINGA R et al.: Tumor eradication by wild-type p53-specific cytotoxic T lymphocytes. J. Exp. Med. (1997) 186(5):695-704. Demonstration that high-avidity p53-specific CTLs can provide tumour protection without causing damage to normal tissues in mice.
-
(1997)
J. Exp. Med.
, vol.186
, Issue.5
, pp. 695-704
-
-
Vierboom, M.P.1
Nijman, H.W.2
Offringa, R.3
-
12
-
-
0029826486
-
Peptide-specific cytotoxic T lymphocytes restricted by nonself major histocompatibility complex class I molecules: Reagents for tumor immunotherapy
-
SADOVNIKOVA E, STAUSS HJ: Peptide-specific cytotoxic T lymphocytes restricted by nonself major histocompatibility complex class I molecules: reagents for tumor immunotherapy. Proc. Natl. Acad. Sci. USA (1996) 93(23):13114-13118. The allo-restricted approach was used to circumvent T cell tolerance in mice and generate high-avidity tumour-reactive CTLs specific for a peptide epitope of MDM2.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, Issue.23
, pp. 13114-13118
-
-
Sadovnikova, E.1
Stauss, H.J.2
-
13
-
-
0031963721
-
Generation of human tumor-reactive cytotoxic T cells against peptides presented by non-self HLA class I molecules
-
SADOVNIKOVA E, JOPLING LA, SOO KS, STAUSS HJ: Generation of human tumor-reactive cytotoxic T cells against peptides presented by non-self HLA class I molecules. Eur. J. Immunol. (1998) 28(1):193-200. A study describing the use of the allo-restricted approach to generate human high-avidity CTLs specific for the broadly expressed TAA cyclin-D1.
-
(1998)
Eur. J. Immunol.
, vol.28
, Issue.1
, pp. 193-200
-
-
Sadovnikova, E.1
Jopling, L.A.2
Soo, K.S.3
Stauss, H.J.4
-
14
-
-
0032893878
-
Regulation of the p53 protein by the MDM2 oncoprotein-thirty-eighth G.H.A. Clowes Memorial Award Lecture
-
FREEDMAN DA, LEVINE AJ: Regulation of the p53 protein by the MDM2 oncoprotein-thirty-eighth G.H.A. Clowes Memorial Award Lecture. Cancer Res. (1999) 59(1):1-7.
-
(1999)
Cancer Res.
, vol.59
, Issue.1
, pp. 1-7
-
-
Freedman, D.A.1
Levine, A.J.2
-
15
-
-
0033959744
-
MDM2-master regulator of the p53 tumor suppressor protein
-
MOMAND J, WU HH, DASGUPTA G: MDM2-master regulator of the p53 tumor suppressor protein. Gene (2000) 242(1-2):15-29.
-
(2000)
Gene
, vol.242
, Issue.1-2
, pp. 15-29
-
-
Momand, J.1
Wu, H.H.2
Dasgupta, G.3
-
16
-
-
0034676455
-
Surfing the p53 network
-
VOGELSTEIN B, LANE D, LEVINE AJ: Surfing the p53 network. Nature (2000) 408(6810):307-310.
-
(2000)
Nature
, vol.408
, Issue.6810
, pp. 307-310
-
-
Vogelstein, B.1
Lane, D.2
Levine, A.J.3
-
17
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
JONES SN, ROE AE, DONEHOWER LA, BRADLEY A: Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (1995) 378(6553):206-208.
-
(1995)
Nature
, vol.378
, Issue.6553
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
18
-
-
0025853776
-
Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
-
FAKHARZADEH SS, TRUSKO SP, GEORGE DL: Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J. (1991) 10(6):1565-1569.
-
(1991)
EMBO J.
, vol.10
, Issue.6
, pp. 1565-1569
-
-
Fakharzadeh, S.S.1
Trusko, S.P.2
George, D.L.3
-
19
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
MOMAND J, ZAMBETTI GP, OLSON DC, GEORGE D, LEVINE AJ: The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell (1992) 69(7):1237-1245.
-
(1992)
Cell
, vol.69
, Issue.7
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
20
-
-
0012956142
-
BCR/ABL activates mdm2 mRNA translation via the la antigen
-
TROTTA R, VIGNUDELLI T, CANDINI O et al.: BCR/ABL activates mdm2 mRNA translation via the La antigen. Cancer Cell (2003) 3(2):145-160.
-
(2003)
Cancer Cell
, vol.3
, Issue.2
, pp. 145-160
-
-
Trotta, R.1
Vignudelli, T.2
Candini, O.3
-
21
-
-
0026740449
-
Amplification of a gene encoding a p53-associated protein in human sarcomas
-
OLINER JD, KINZLER KW, MELTZER PS, GEORGE DL, VOGELSTEIN B: Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (1992) 358(6381):80-83.
-
(1992)
Nature
, vol.358
, Issue.6381
, pp. 80-83
-
-
Oliner, J.D.1
Kinzler, K.W.2
Meltzer, P.S.3
George, D.L.4
Vogelstein, B.5
-
22
-
-
0027368879
-
The human MDM-2 oncogene is overexpressed in leukemias
-
BUESO-RAMOS CE, YANG Y, DELEON E et al.: The human MDM-2 oncogene is overexpressed in leukemias. Blood (1993) 82(9):26l7-2623.
-
(1993)
Blood
, vol.82
, Issue.9
-
-
Bueso-Ramos, C.E.1
Yang, Y.2
Deleon, E.3
-
23
-
-
0027196974
-
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
-
REIFENBERGER G, LIU L, ICHIMURA K, SCHMIDT EE, COLLINS VP: Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res. (1993) 53(12):2736-2739.
-
(1993)
Cancer Res.
, vol.53
, Issue.12
, pp. 2736-2739
-
-
Reifenberger, G.1
Liu, L.2
Ichimura, K.3
Schmidt, E.E.4
Collins, V.P.5
-
24
-
-
0031038269
-
Mdm-2: 'Big brother' of p53
-
MOMAND J, ZAMBETTI GP: Mdm-2: 'big brother' of p53. J. Cell. Biochem. (1997) 64(3):343-352.
-
(1997)
J. Cell. Biochem.
, vol.64
, Issue.3
, pp. 343-352
-
-
Momand, J.1
Zambetti, G.P.2
-
25
-
-
0037080023
-
Can the low-avidity self-specific T cell repertoire be exploited for tumor rejection?
-
CORDARO TA, DE VISSER KE, TIRION FH, SCHUMACHER TN, KRUISBEEK AM: Can the low-avidity self-specific T cell repertoire be exploited for tumor rejection? J. Immunol. (2002) 168(2):651-660.
-
(2002)
J. Immunol.
, vol.168
, Issue.2
, pp. 651-660
-
-
Cordaro, T.A.1
De Visser, K.E.2
Tirion, F.H.3
Schumacher, T.N.4
Kruisbeek, A.M.5
-
26
-
-
0031963994
-
Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity
-
MORGAN DJ, KREUWEL HT, FLECK S et al.: Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity. J. Immunol. (1998) 160(2):643-651.
-
(1998)
J. Immunol.
, vol.160
, Issue.2
, pp. 643-651
-
-
Morgan, D.J.1
Kreuwel, H.T.2
Fleck, S.3
-
27
-
-
0033556322
-
High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy
-
ZEH HJ 3RD, PERRY-LALLEY D, DUDLEY ME, ROSENBERG SA, YANG JC: High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy. J. Immunol. (1999) 162(2):989-994.
-
(1999)
J. Immunol.
, vol.162
, Issue.2
, pp. 989-994
-
-
Zeh III, H.J.1
Perry-Lalley, D.2
Dudley, M.E.3
Rosenberg, S.A.4
Yang, J.C.5
-
28
-
-
0036644333
-
Antimelanoma activity of CTL generated from peripheral blood mononuclear cells after stimulation with autologous dendritic cells pulsed with melanoma gp100 peptide G209-2M is correlated to TCR avidity
-
YANG S, LINETTE GP, LONGERICH S, HALUSKA FG: Antimelanoma activity of CTL generated from peripheral blood mononuclear cells after stimulation with autologous dendritic cells pulsed with melanoma gp100 peptide G209-2M is correlated to TCR avidity. J. Immunol. (2002) 169(1):531-539.
-
(2002)
J. Immunol.
, vol.169
, Issue.1
, pp. 531-539
-
-
Yang, S.1
Linette, G.P.2
Longerich, S.3
Haluska, F.G.4
-
29
-
-
0029965055
-
Selective expansion of high- Or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy
-
ALEXANDER-MILLER MA, LEGGATT GR, BERZOFSKY JA: Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc. Natl. Acad. Sci. USA (1996) 93:4102-4107.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 4102-4107
-
-
Alexander-Miller, M.A.1
Leggatt, G.R.2
Berzofsky, J.A.3
-
30
-
-
0034624983
-
In vitro evolution of a T cell receptor with high affinity for peptide/MHC
-
HOLLER PD, HOLMAN PO, SHUSTA EV et al.: In vitro evolution of a T cell receptor with high affinity for peptide/MHC. Proc. Natl. Acad. Sci. USA (2000) 97(10):5387-5392.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, Issue.10
, pp. 5387-5392
-
-
Holler, P.D.1
Holman, P.O.2
Shusta, E.V.3
-
31
-
-
0037309288
-
Transfer of TCR genes into mature T cells is accompanied by the maintenance of parental T cell avidity
-
RUBINSTEIN MP, KADIMA AN, SALEM ML et al.: Transfer of TCR genes into mature T cells is accompanied by the maintenance of parental T cell avidity. J. Immunol. (2003) 170:1209-1217.
-
(2003)
J. Immunol.
, vol.170
, pp. 1209-1217
-
-
Rubinstein, M.P.1
Kadima, A.N.2
Salem, M.L.3
-
32
-
-
0034907484
-
How much TCR does a T cell need?
-
LABRECQUE N, WHITFIELD LS, OBST R et al.: How much TCR does a T cell need? Immunity (2001) 15(1):71-82.
-
(2001)
Immunity
, vol.15
, Issue.1
, pp. 71-82
-
-
Labrecque, N.1
Whitfield, L.S.2
Obst, R.3
-
33
-
-
0035451399
-
Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: Correlation with CD8alphabeta versus CD8alphaalpha expression
-
CAWTHON AG, LU H, ALEXANDER-MILLER MA: Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: correlation with CD8alphabeta versus CD8alphaalpha expression. J. Immunol. (2001) 167(5):2577-2584.
-
(2001)
J. Immunol.
, vol.167
, Issue.5
, pp. 2577-2584
-
-
Cawthon, A.G.1
Lu, H.2
Alexander-Miller, M.A.3
-
34
-
-
0033571386
-
CD2 sets quantitative thresholds in T cell activation
-
BACHMANN MF, BARNER M, KOPF M: CD2 sets quantitative thresholds in T cell activation. J. Exp. Med. (1999) 190(10):1383-1391.
-
(1999)
J. Exp. Med.
, vol.190
, Issue.10
, pp. 1383-1391
-
-
Bachmann, M.F.1
Barner, M.2
Kopf, M.3
-
35
-
-
0034610974
-
Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease
-
LUDEWIG B, OCHSENBEIN AF, ODERMATT B et al.: Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease. J. Exp. Med. (2000) 191(5):795-804.
-
(2000)
J. Exp. Med.
, vol.191
, Issue.5
, pp. 795-804
-
-
Ludewig, B.1
Ochsenbein, A.F.2
Odermatt, B.3
-
36
-
-
0035554675
-
The risk of autoimmunity associated with tumor immunotherapy
-
GILBOA E: The risk of autoimmunity associated with tumor immunotherapy. Nat. Immunol. (2001) 2(9):789-792.
-
(2001)
Nat. Immunol.
, vol.2
, Issue.9
, pp. 789-792
-
-
Gilboa, E.1
-
37
-
-
17944364189
-
Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: Comparison of prophylaxis and therapy
-
VAN ELSAS A, SUTMULLER RP, HURWITZ AA et al.: Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J. Exp. Med. (2001) 194(4):481-489.
-
(2001)
J. Exp. Med.
, vol.194
, Issue.4
, pp. 481-489
-
-
Van Elsas, A.1
Sutmuller, R.P.2
Hurwitz, A.A.3
-
38
-
-
0032533459
-
Passive but not active CD8+ T cell-based immunotherapy interferes with liver tumor progression in a transgenic mouse model
-
ROMIEU R, BARATIN M, KAYIBANDA M et al.: Passive but not active CD8+ T cell-based immunotherapy interferes with liver tumor progression in a transgenic mouse model. J. Immunol. (1998) 161(10):5133-5137. Demonstration that vaccine-induced low-avidity CTLs are less effective than adoptively transferred high-avidity CTLs at controlling tumour growth in vivo.
-
(1998)
J. Immunol.
, vol.161
, Issue.10
, pp. 5133-5137
-
-
Romieu, R.1
Baratin, M.2
Kayibanda, M.3
-
39
-
-
0032987983
-
Cytotoxic T-lymphocyte epitope immunodominance in the control of choroid plexus tumors in simian virus 40 large T antigen transgenic mice
-
SCHELL TD, MYLIN LM, GEORGOFF I et al.: Cytotoxic T-lymphocyte epitope immunodominance in the control of choroid plexus tumors in simian virus 40 large T antigen transgenic mice. J. Virol. (1999) 73(7):5981-5993.
-
(1999)
J. Virol.
, vol.73
, Issue.7
, pp. 5981-5993
-
-
Schell, T.D.1
Mylin, L.M.2
Georgoff, I.3
-
40
-
-
0032954938
-
Adoptive immunotherapy prevents prostate cancer in a transgenic animal model
-
GRANZIERO L, KRAJEWSKI S, FARNESS P et al.: Adoptive immunotherapy prevents prostate cancer in a transgenic animal model. Eur. J. Immunol. (1999) 29(4):1127-1138.
-
(1999)
Eur. J. Immunol.
, vol.29
, Issue.4
, pp. 1127-1138
-
-
Granziero, L.1
Krajewski, S.2
Farness, P.3
-
41
-
-
0028884728
-
Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides
-
MANDELBOIM O, VADAI E, FRIDKIN M et al.: Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides. Nat. Med. (1995) 1(11):1179-1183.
-
(1995)
Nat. Med.
, vol.1
, Issue.11
, pp. 1179-1183
-
-
Mandelboim, O.1
Vadai, E.2
Fridkin, M.3
-
42
-
-
0036493558
-
In vivo manipulation of dendritic cells to induce therapeutic immunity
-
MERAD M, SUGIE T, ENGLEMAN EG, FONG L: In vivo manipulation of dendritic cells to induce therapeutic immunity. Blood (2002) 99(5):1676-1682.
-
(2002)
Blood
, vol.99
, Issue.5
, pp. 1676-1682
-
-
Merad, M.1
Sugie, T.2
Engleman, E.G.3
Fong, L.4
-
43
-
-
0033514923
-
Immune surveillance against a solid tumor fails because of immunological ignorance
-
OCHSENBEIN AF, KLENERMAN P, KARRER U et al.: Immune surveillance against a solid tumor fails because of immunological ignorance. Proc. Natl. Acad. Sci. USA (1999) 96(5):2233-2238.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, Issue.5
, pp. 2233-2238
-
-
Ochsenbein, A.F.1
Klenerman, P.2
Karrer, U.3
-
44
-
-
0030892137
-
Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes
-
THEOBALD M, BIGGS J, HERNANDEZ J et al.: Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes. J. Exp. Med. (1997) 185(5):833-841. A study illustrating the effects of immunological tolerance on the CTL repertoire specific for p53 in HLA-A2 transgenic mice.
-
(1997)
J. Exp. Med.
, vol.185
, Issue.5
, pp. 833-841
-
-
Theobald, M.1
Biggs, J.2
Hernandez, J.3
-
45
-
-
0029952513
-
A synthetic peptide derived from the tumor-associated protein mdm2 can stimulate autoreactive, high avidity cytotoxic T lymphocytes that recognize naturally processed protein
-
DAHL AM, BEVERLEY PC, STAUSS HJ: A synthetic peptide derived from the tumor-associated protein mdm2 can stimulate autoreactive, high avidity cytotoxic T lymphocytes that recognize naturally processed protein. J. Immunol. (1996) 157(1):239-246. A report investigating whether tumour-reactive self-MHC-restricted murine CTLs specific for peptide epitopes of MDM2 can be generated in vitro.
-
(1996)
J. Immunol.
, vol.157
, Issue.1
, pp. 239-246
-
-
Dahl, A.M.1
Beverley, P.C.2
Stauss, H.J.3
-
46
-
-
1042292578
-
Incomplete tolerance to the tumour-associated antigen MDM2
-
RAMIREZ F, GHANI Y, STAUSS H: Incomplete tolerance to the tumour-associated antigen MDM2. Int. Immunol. (2004) 16(2):327-334. A study demonstrating that MDM2 peptide vaccination does not prevent the growth of MDM2-expressing tumours in mice.
-
(2004)
Int. Immunol.
, vol.16
, Issue.2
, pp. 327-334
-
-
Ramirez, F.1
Ghani, Y.2
Stauss, H.3
-
47
-
-
0034780027
-
Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer
-
STANISLAWSKI T, VOSS RH, LOTZ C et al.: Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer. Nat. Immunol. (2001) 2(10):962-970. HLA-A2 transgenic mice were used to circumvent T cell tolerance and generate high-avidity HLA-A2-restricted MDM2-specific CTLs. Retroviral transfer of the TCR genes isolated from the CTLs generated human tumour-reactive MDM2-specific CTLs.
-
(2001)
Nat. Immunol.
, vol.2
, Issue.10
, pp. 962-970
-
-
Stanislawski, T.1
Voss, R.H.2
Lotz, C.3
-
48
-
-
7444232644
-
Induction of unresponsiveness limits tumor protection by adoptively transferred MDM2-specific cytotoxic T lymphocytes
-
BENDLE GM, HOLLER A, PANG LK et al.: Induction of unresponsiveness limits tumor protection by adoptively transferred MDM2-specific cytotoxic T lymphocytes. Cancer Res. (2004) 64(21):8052-8056. Demonstration that adoptive immunotherapy with high-avidity MDM2-specific CTLs can be safe, but the induction of tolerance in transferred CTLs may limit their therapeutic efficacy.
-
(2004)
Cancer Res.
, vol.64
, Issue.21
, pp. 8052-8056
-
-
Bendle, G.M.1
Holler, A.2
Pang, L.K.3
-
49
-
-
4644324025
-
Cancer immunotherapy: Moving beyond current vaccines
-
ROSENBERG SA, YANG JC, RESTIFO NP: Cancer immunotherapy: moving beyond current vaccines. Nat. Med. (2004) 10(9):909-915.
-
(2004)
Nat. Med.
, vol.10
, Issue.9
, pp. 909-915
-
-
Rosenberg, S.A.1
Yang, J.C.2
Restifo, N.P.3
-
50
-
-
4644289323
-
Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression
-
OKA Y, TSUBOI A, TAGUCHI T et al.: Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression. Proc. Natl. Acad. Sci. USA (2004) 101(38):13885-13890.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.38
, pp. 13885-13890
-
-
Oka, Y.1
Tsuboi, A.2
Taguchi, T.3
-
51
-
-
0035902607
-
Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy
-
FONG L, HOU Y, RIVAS A et al.: Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy. Proc. Natl. Acad. Sci. USA (2001) 98(15):8809-8814.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, Issue.15
, pp. 8809-8814
-
-
Fong, L.1
Hou, Y.2
Rivas, A.3
-
52
-
-
0035417932
-
Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine
-
BANCHEREAU J, PALUCKA AK, DHODAPKAR M et al.: Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine. Cancer Res. (2001) 61(17):6451-6458.
-
(2001)
Cancer Res.
, vol.61
, Issue.17
, pp. 6451-6458
-
-
Banchereau, J.1
Palucka, A.K.2
Dhodapkar, M.3
-
53
-
-
19944434269
-
High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumor antigens
-
GERMEAU C, MA W, SCHIAVETTI F et al.: High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumor antigens. J. Exp. Med. (2005) 201(2):241-248.
-
(2005)
J. Exp. Med.
, vol.201
, Issue.2
, pp. 241-248
-
-
Germeau, C.1
Ma, W.2
Schiavetti, F.3
-
54
-
-
13244273592
-
Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen
-
LURQUIN C, LETHE B, DE PLAEN E et al.: Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen. J. Exp. Med. (2005) 201(2):249-257.
-
(2005)
J. Exp. Med.
, vol.201
, Issue.2
, pp. 249-257
-
-
Lurquin, C.1
Lethe, B.2
De Plaen, E.3
-
55
-
-
0037302519
-
Determinant spreading and tumor responses after peptide-based cancer immunotherapy
-
RIBAS A, TIMMERMAN JM, BUTTERFIELD LH, ECONOMOU JS: Determinant spreading and tumor responses after peptide-based cancer immunotherapy. Trends Immunol. (2003) 24(2):58-61.
-
(2003)
Trends Immunol.
, vol.24
, Issue.2
, pp. 58-61
-
-
Ribas, A.1
Timmerman, J.M.2
Butterfield, L.H.3
Economou, J.S.4
-
56
-
-
0025100777
-
Graft-versus-leukemia reactions after bone marrow transplantation
-
HOROWITZ MM, GALE RP, SONDEL PM et al.: Graft-versus-leukemia reactions after bone marrow transplantation. Blood (1990) 75(3):555-562.
-
(1990)
Blood
, vol.75
, Issue.3
, pp. 555-562
-
-
Horowitz, M.M.1
Gale, R.P.2
Sondel, P.M.3
-
57
-
-
0029027351
-
Identification of a graft versus host disease-associated human minor histocompatibility antigen
-
DEN HAAN JM, SHERMAN NE, BLOKLAND E et al.: Identification of a graft versus host disease-associated human minor histocompatibility antigen. Science (1995) 268(5216):1476-1480.
-
(1995)
Science
, vol.268
, Issue.5216
, pp. 1476-1480
-
-
Den Haan, J.M.1
Sherman, N.E.2
Blokland, E.3
-
58
-
-
0033575383
-
Prevention of graft versus host disease by inactivation of host antigen-presenting cells
-
SHLOMCHIK WD, COUZENS MS, TANG CB et al.: Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science (1999) 285(5426):412-415.
-
(1999)
Science
, vol.285
, Issue.5426
, pp. 412-415
-
-
Shlomchik, W.D.1
Couzens, M.S.2
Tang, C.B.3
-
59
-
-
0037058993
-
Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells
-
YEE C, THOMPSON JA, BYRD D et al.: Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc. Natl. Acad. Sci. USA (2002) 99(25):16168-16173.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, Issue.25
, pp. 16168-16173
-
-
Yee, C.1
Thompson, J.A.2
Byrd, D.3
-
60
-
-
5144226237
-
Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes
-
ROSENBERG SA, DUDLEY ME: Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes. Proc. Natl. Acad. Sci. USA (2004) 101(Suppl. 2):14639-14645.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.SUPPL. 2
, pp. 14639-14645
-
-
Rosenberg, S.A.1
Dudley, M.E.2
-
61
-
-
0037174674
-
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
-
DUDLEY ME, WUNDERLICH JR, ROBBINS PF et al.: Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science (2002) 298(5594):850-854.
-
(2002)
Science
, vol.298
, Issue.5594
, pp. 850-854
-
-
Dudley, M.E.1
Wunderlich, J.R.2
Robbins, P.F.3
-
62
-
-
0041419656
-
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells
-
OVERWIJK WW, THEORET MR, FINKELSTEIN SE et al.: Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells. J. Exp. Med. (2003) 198(4):569-580.
-
(2003)
J. Exp. Med.
, vol.198
, Issue.4
, pp. 569-580
-
-
Overwijk, W.W.1
Theoret, M.R.2
Finkelstein, S.E.3
-
63
-
-
0034687706
-
Changing T cell specificity by retroviral T cell receptor display
-
KESSELS HW, VAN DEN BOOM MD, SPITS H, HOOIJBERG E, SCHUMACHER TN: Changing T cell specificity by retroviral T cell receptor display. Proc. Natl. Acad. Sci. USA (2000) 97(26):14578-14583. A study demonstrating that in vitro mutagenesis of TCRs can be used to change their affinity and/or specificity, thereby circumventing T cell tolerance.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, Issue.26
, pp. 14578-14583
-
-
Kessels, H.W.1
Van Den Boom, M.D.2
Spits, H.3
Hooijberg, E.4
Schumacher, T.N.5
-
64
-
-
0032909172
-
Immunotherapy with CTLs restricted by nonself MHC
-
STAUSS HJ: Immunotherapy with CTLs restricted by nonself MHC. Immunol. Today (1999) 20(4):180-183.
-
(1999)
Immunol. Today
, vol.20
, Issue.4
, pp. 180-183
-
-
Stauss, H.J.1
-
65
-
-
0034176750
-
Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1
-
GAO L, BELLANTUONO I, ELSASSER A et al.: Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1. Blood(2000) 95(7):2198-2203.
-
(2000)
Blood
, vol.95
, Issue.7
, pp. 2198-2203
-
-
Gao, L.1
Bellantuono, I.2
Elsasser, A.3
-
66
-
-
12744253307
-
Sinks, suppressors and antigen presenters: How lymphodepletion enhances T cell-mediated tumor immunotherapy
-
KLEBANOFF CA, KHONG HT, ANTONY PA, PALMER DC, RESTIFO NP: Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy. Trends Immunol. (2005) 26(2):111-117.
-
(2005)
Trends Immunol.
, vol.26
, Issue.2
, pp. 111-117
-
-
Klebanoff, C.A.1
Khong, H.T.2
Antony, P.A.3
Palmer, D.C.4
Restifo, N.P.5
-
67
-
-
19944434233
-
Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR
-
+ helper T cells.
-
(2005)
Immunity
, vol.22
, Issue.1
, pp. 117-129
-
-
Kuball, J.1
Schmitz, F.W.2
Voss, R.H.3
-
68
-
-
0033168142
-
Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity
-
CLAY TM, CUSTER MC, SACHS J et al.: Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity. J. Immunol. (1999) 163(1):507-513.
-
(1999)
J. Immunol.
, vol.163
, Issue.1
, pp. 507-513
-
-
Clay, T.M.1
Custer, M.C.2
Sachs, J.3
-
69
-
-
0034769412
-
Immunotherapy through TCR gene transfer
-
KESSELS HW, WOLKERS MC, VAN DEN BOOM MD, VAN DER VALK MA, SCHUMACHER TN: Immunotherapy through TCR gene transfer. Nat. Immunol. (2001) 2(10):957-961. The first study showing that TCR-transduced T cells can persist and function in vivo in mice.
-
(2001)
Nat. Immunol.
, vol.2
, Issue.10
, pp. 957-961
-
-
Kessels, H.W.1
Wolkers, M.C.2
Van Den Boom, M.D.3
Van Der Valk, M.A.4
Schumacher, T.N.5
-
70
-
-
0042834246
-
High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens
-
MORGAN RA, DUDLEY ME, YU YY et al.: High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens. J. Immunol. (2003) 171(6):3287-3295.
-
(2003)
J. Immunol.
, vol.171
, Issue.6
, pp. 3287-3295
-
-
Morgan, R.A.1
Dudley, M.E.2
Yu, Y.Y.3
-
71
-
-
0024976414
-
Tolerance of class I histocompatibility antigens expressed extrathymically
-
MORAHAN G, ALLISON J, MILLER JF: Tolerance of class I histocompatibility antigens expressed extrathymically. Nature (1989) 339(6226):622-624.
-
(1989)
Nature
, vol.339
, Issue.6226
, pp. 622-624
-
-
Morahan, G.1
Allison, J.2
Miller, J.F.3
-
72
-
-
0027532184
-
Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen
-
ROCHA B, TANCHOT C, VON BOEHMER H: Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J. Exp. Med. (1993) 177(5):1517-1521.
-
(1993)
J. Exp. Med.
, vol.177
, Issue.5
, pp. 1517-1521
-
-
Rocha, B.1
Tanchot, C.2
Von Boehmer, H.3
-
73
-
-
0033103127
-
CD4 T cells and their role in antitumor immune responses
-
TOES RE, OSSENDORP F, OFFRINGA R, MELIEF CJ: CD4 T cells and their role in antitumor immune responses. J. Exp. Med. (1999) 189(5):753-756.
-
(1999)
J. Exp. Med.
, vol.189
, Issue.5
, pp. 753-756
-
-
Toes, R.E.1
Ossendorp, F.2
Offringa, R.3
Melief, C.J.4
-
74
-
-
0034919646
-
The role of MHC class II-restricted tumor antigens and CD4+ T cells in antitumor immunity
-
WANG RF: The role of MHC class II-restricted tumor antigens and CD4+ T cells in antitumor immunity. Trends Immunol. (2001) 22(5):269-276.
-
(2001)
Trends Immunol.
, vol.22
, Issue.5
, pp. 269-276
-
-
Wang, R.F.1
-
75
-
-
0032473562
-
Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors
-
OSSENDORP F, MENGEDE E, CAMPS M, FILIUS R, MELIEF CJ: Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors. J. Exp. Med. (1998) 187(5):693-702.
-
(1998)
J. Exp. Med.
, vol.187
, Issue.5
, pp. 693-702
-
-
Ossendorp, F.1
Mengede, E.2
Camps, M.3
Filius, R.4
Melief, C.J.5
-
76
-
-
0037103249
-
Opposing effects of IL-2 in tumor immunotherapy: Promoting CD8 T cell growth and inducing apoptosis
-
SHRIKANT P, MESCHER MF: Opposing effects of IL-2 in tumor immunotherapy: promoting CD8 T cell growth and inducing apoptosis. J. Immunol. (2002) 169(4):1753-1759.
-
(2002)
J. Immunol.
, vol.169
, Issue.4
, pp. 1753-1759
-
-
Shrikant, P.1
Mescher, M.F.2
-
77
-
-
0034541167
-
Tumor-specific CD4+ T cells have a major 'post-licensing' role in CTL mediated anti-tumor immunity
-
MARZO AL, KINNEAR BF, LAKE RA et al.: Tumor-specific CD4+ T cells have a major 'post-licensing' role in CTL mediated anti-tumor immunity. J. Immunol. (2000) 165(11):6047-6055.
-
(2000)
J. Immunol.
, vol.165
, Issue.11
, pp. 6047-6055
-
-
Marzo, A.L.1
Kinnear, B.F.2
Lake, R.A.3
-
78
-
-
0037144612
-
A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
-
BOURGEOIS C, ROCHA B, TANCHOT C: A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science (2002) 297(5589):2060-2063.
-
(2002)
Science
, vol.297
, Issue.5589
, pp. 2060-2063
-
-
Bourgeois, C.1
Rocha, B.2
Tanchot, C.3
-
79
-
-
0037456367
-
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
-
JANSSEN EM, LEMMENS EE, WOLFE T et al.: CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature (2003) 421(6925):852-856.
-
(2003)
Nature
, vol.421
, Issue.6925
, pp. 852-856
-
-
Janssen, E.M.1
Lemmens, E.E.2
Wolfe, T.3
-
80
-
-
4644271443
-
CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection
-
SUN JC, WILLIAMS MA, BEVAN MJ: CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat. Immunol. (2004) 5(9):927-933.
-
(2004)
Nat. Immunol.
, vol.5
, Issue.9
, pp. 927-933
-
-
Sun, J.C.1
Williams, M.A.2
Bevan, M.J.3
-
81
-
-
0033662405
-
CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells
-
QIN Z, BLANKENSTEIN T: CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells. Immunity (2000) 12(6):677-686.
-
(2000)
Immunity
, vol.12
, Issue.6
, pp. 677-686
-
-
Qin, Z.1
Blankenstein, T.2
-
82
-
-
0028023727
-
Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene
-
TOPALIAN SL, RIVOLTINI L, MANCINI M et al.: Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene. Proc. Natl. Acad. Sci. USA (1994) 91(20):9461-9465.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, Issue.20
, pp. 9461-9465
-
-
Topalian, S.L.1
Rivoltini, L.2
Mancini, M.3
-
83
-
-
10944270781
-
Identification of a naturally processed cyclin D1 T-helper epitope by a novel combination of HLA class II targeting and differential mass spectrometry
-
DENGJEL J, DECKER P, SCHOOR O et al.: Identification of a naturally processed cyclin D1 T-helper epitope by a novel combination of HLA class II targeting and differential mass spectrometry. Eur.J. Immunol. (2004) 34(12):3644-3651.
-
(2004)
Eur.J. Immunol.
, vol.34
, Issue.12
, pp. 3644-3651
-
-
Dengjel, J.1
Decker, P.2
Schoor, O.3
-
85
-
-
13244265603
-
Redirecting human CD4+ T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCRαβ gene transfer requires CD8α
-
WILLEMSEN R, RONTELTAP C, HEUVELING M, DEBETS R, BOLHUIS R: Redirecting human CD4+ T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCRαβ gene transfer requires CD8α. Gene Ther. (2005) 12:140-146.
-
(2005)
Gene Ther.
, vol.12
, pp. 140-146
-
-
Willemsen, R.1
Ronteltap, C.2
Heuveling, M.3
Debets, R.4
Bolhuis, R.5
-
86
-
-
13944278036
-
Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor
-
ROSZKOWSKI JJ, LYONS GE, KAST WM et al.: Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor. Cancer Res. (2005) 65(4):1570-1576.
-
(2005)
Cancer Res.
, vol.65
, Issue.4
, pp. 1570-1576
-
-
Roszkowski, J.J.1
Lyons, G.E.2
Kast, W.M.3
-
87
-
-
0037022629
-
Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death
-
CHENG LE, OHLEN C, NELSON BH, GREENBERG PD: Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death. Proc. Natl. Acad. Sci. USA (2002) 99(5):3001-3006.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, Issue.5
, pp. 3001-3006
-
-
Cheng, L.E.1
Ohlen, C.2
Nelson, B.H.3
Greenberg, P.D.4
-
88
-
-
4644364500
-
Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo
-
LOU Y, WANG G, LIZEE G et al.: Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo. Cancer Res. (2004) 64(18):6783-6790. A study showing that DC vaccination can improve the tumour-protective efficacy of adoptively transferred CTLs in mice.
-
(2004)
Cancer Res.
, vol.64
, Issue.18
, pp. 6783-6790
-
-
Lou, Y.1
Wang, G.2
Lizee, G.3
-
89
-
-
0037148344
-
Telomerase as a universal tumor-associated antigen for cancer immunotherapy
-
VONDERHEIDE RH: Telomerase as a universal tumor-associated antigen for cancer immunotherapy. Oncogene (2002) 21(4):674-679.
-
(2002)
Oncogene
, vol.21
, Issue.4
, pp. 674-679
-
-
Vonderheide, R.H.1
|