The vanB2 gene cluster of the majority of vancomycin-resistant Enterococcus faecium isolates from Taiwan is associated with the pbp5 gene and is carried by Tn5382 containing a novel insertion sequence

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 9, 2005, Pages 3937-3939

  Lu, Jang Jih ^a,b   Chang, Tein Yao ^a   Perng, Cherng Lih ^a   Lee, Shih Yi ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NONE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSPOSASE;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; ENTEROCOCCUS FAECIUM; GENE CLUSTER; GENE INSERTION SEQUENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PBP5 GENE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TAIWAN; TRANSPOSON; VANB2 GENE;

BACTERIAL PROTEINS; DNA TRANSPOSABLE ELEMENTS; DNA, BACTERIAL; ENTEROCOCCUS FAECIUM; GENES, BACTERIAL; GRAM-POSITIVE BACTERIAL INFECTIONS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PENICILLIN-BINDING PROTEINS; TAIWAN; VANCOMYCIN RESISTANCE;

EID: 24144441742     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.9.3937-3939.2005     Document Type: Article

References (17)

1. Bonten, M. J., R. Willems, and R. A. Weinstein. 2001. Vancomycin-resistant enterococci: why are they here, and where do they come from? Lancet Infect. Dis. 1:314-325.
2. Carias, L. L., S. D. Rudin, C. J. Donskey, and L. B. Rice. 1998. Genetic linkage and cotransfer of a novel, vanB-containing transposon (Tn5382) and a low-affinity penicillin-binding protein 5 gene in a clinical vancomycin-resistant Enterococcus faecium isolate. J. Bacteriol. 180:4426-4434.
3. Chandler, M., and J. Mahillon. 2000. Insertion sequence nomenclature. ASM News 66:324.
4. Dahl, K. H., E. W. Lundblad, T. P. Rokenes, O. Olsvik, and A. Sundsfjord. 2000. Genetic linkage of the vanB2 gene cluster to Tn5382 in vancomycin-resistant enterococci and characterization of two novel insertion sequences. Microbiology 146:1469-1479.
5. Dahl, K. H., G. S. Simonsen, O. Olsvik, and A. Sundsfjord. 1999. Heterogeneity in the vanB gene cluster of genomically diverse clinical strains of vancomycin-resistant enterococci. Antimicrob. Agents Chemother. 43:1105-1110.
6. B two-component regulatory system in Enterococcus faecalis V583. J. Bacteriol. 178:1302-1309.
7. Garnier, F., S. Taourit, P. Glaser, P. Courvalin, and M. Galimand. 2000. Characterization of transposon Tn1549, conferring VanB-type resistance in Enterococcus spp. Microbiology 146:1481-1489.
8. Hanrahan, J., C. Hoyen, and L. B. Rice. 2000. Geographic distribution of a large mobile clement that transfers ampicillin and vancomycin resistance between Enterococcus faecium strains. Antimicrob. Agents Chemother. 44:1349-1351.
9. Lee, W. G., J. A. Jernigan, J. K. Rasheed, G. J. Anderson, and F. C. Tenover. 2001. Possible horizontal transfer of the vanB2 gene among genetically diverse strains of vancomycin-resistant Enterococcus faecium in a Korean hospital. J. Clin. Microbiol. 39:1165-1168.
10. Lee, W. G., and W. Kim. 2003. Identification of a novel insertion sequence in vanB2-containing Enterococcus faecium. Lett. Appl. Microbiol. 36:186-190.
11. Linden, P. K., and C. B. Miller. 1999. Vancomycin-resistant enterococci: the clinical effect of a common nosocomial pathogen. Diagn. Microbiol. Infect. Dis. 33:113-120.
12. Lu, J. J., C. L. Perng, T. S. Chiueh, S. Y. Lee, C. H. Chen, F. Y. Chang, C. C. Wang, and W. M. Chi. 2001. Detection and typing of vancomycin-resistance genes of enterococci from clinical and nosoeomial surveillance specimens by multiplex PCR. Epidemiol. Infect. 126:357-363.
13. Lu, J.-J., C.-L. Perng, M.-F. Ho, T.-S. Chiueh, and W.-H. Lee. 2001. High prevalence of VanB2 vancomycin-resistant Enterococcus fuecium in Taiwan. J. Clin. Microbiol. 39:2140-2145.
14. McGregor, K. F., C. Nolan, H.-K. Young, M.-F. I. Palepou, L. Tysall, and N. Woodford. 2001. Prevalence of the vanB2 gene cluster in vanB glycopeptide-resistant enterococci in the United Kingdom and the Republic of Ireland and its association with a Tn5382-like element. Antimicrob. Agents Chemother. 45:.367-368.
15. Quintiliani, R., Jr., and P. Courvalin. 1996. Characterization of Tn1547, a composite transposon flanked by the IS16 and IS256-like elements, that confers vancomycin resistance in Enterococcus faecalis BM4281. Gene 172:1-8.
16. Rice, L. B., and A. S. Thorisdottir. 1994. The prevalence of sequences homologous to IS256 in clinical enterococcal isolates. Plasmid 32:344-349.
17. Umeda, A., F. Garnier, P. Courvalin, and M. Galimand. 2002. Association between the vanB2 glycopeptide resistance operon and Tn1549 in enterococci from France. J. Antimicrob. Chemother. 50:253-256.