99mTc-EC-guanine: Synthesis, biodistribution, and tumor imaging in animals

Pharmaceutical Research

Volumn 22, Issue 9, 2005, Pages 1471-1479

  Yang, David J ^a   Ozaki, Kaoru ^a   Oh, Chang Sok ^a   Azhdarinia, Ali ^a   Yang, Thomas ^a   Ito, Megumi ^a   Greenwell, Allison ^a   Bryant, Jerry ^a   Kohanim, Saady ^a   Wong, Vincenzo K ^a   Kim, E Edmund ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Biodistribution; EC Guan; Proliferation; SPECT

Indexed keywords

DNA; ETHYLENEDICYSTEINE GUANINE TC 99M; RADIOPHARMACEUTICAL AGENT; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CELL CULTURE EQUIPMENT; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ASSAY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMAGING; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; RODENT; SCINTIGRAPHY; TISSUE DISTRIBUTION; TUMOR CELL;

ANIMALS; AUTORADIOGRAPHY; CELL CYCLE; GUANINE; HUMANS; MALE; ORGANOTECHNETIUM COMPOUNDS; PROSTATIC NEOPLASMS; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; SIMPLEXVIRUS; THYMIDINE KINASE; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TUMOR CELLS, CULTURED;

EID: 24044512334     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-6157-8     Document Type: Article

References (34)

1. 3H]thymidine, and gallium-67 J. Nucl. Med. 32 2118 2123
2. J. Okada K. Yoshihawa M. Itami K. Imaseki K. Uno J. Itami J. Kuyama A. Mikata N. Arimizu 1992 Positron emission tomography using fluorine-18- fluorodeoxyglucose in malignant lymphoma: a comparison with proliferative activity J. Nucl. Med. 33 325 329
3. K. Higashi A. C. Clavo R. L. Wahl 1992 Does FDG uptake measure proliferative activity of human cancer cells? In vitro comparison with DNA flow cytometry and tritiated thymidine uptake J. Nucl. Med. 34 414 419
4. J. McConathy L. Martarello E. J. Malveaux V. M. Camp N. E. Simpson C. P. Simpson G. D. Bowers Z. Zhang J. J. Olson M. M. Goodman 2003 Synthesis and evaluation of 2-amino-4-[(18)F]fluoro-2-methylbutanoic acid (FAMB): relationship of amino acid transport to tumor imaging properties of branched fluorinated amino acids Nucl. Med. Biol. 30 477 490
5. P. L. Jager B. E. Plaat E. G. de Vries W. M. Molenaar W. Vaalburg D. A. Piers H. J. Hoekstra 2000 Imaging of soft-tissue tumors using l-3-[iodine-123]iodo-alpha-methyl-tyrosine single photon emission computed tomography: comparison with proliferative and mitotic activity, cellularity, and vascularity Clin. Cancer Res. 6 2252 2259
6. J. G. Tjuvajev M. Doubrovin T. Akhurst S. Cai J. Balatoni M. M. Alauddin R. Finn W. Bornmann H. Thaler P. S. Conti R. G. Blasberg 2002 Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression J. Nucl. Med. 43 1072 1083
7. 18F] fluoroguanine derivatives: in vivo probes for imaging gene expression with positron emission tomography Nucl. Med. Biol. 27 157 162
8. S. S. Gambhir E. Bauer M. E. Black Q. Liang M. S. Kokoris J. R. Barrio M. Iyer M. Namavari M. E. Phelps H. R. Herschman 2000 A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography Proc. Natl. Acad. Sci. USA 97 2785 2790
9. M. Iyer J. R. Barrio M. Namavari E. Bauer N. Satyamurthy K. Nguyen T. Toyokuni M. E. Phelps H. R. Herschman S. S. Gambhir 2001 8-[18F] Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET J. Nucl. Med. 42 96 105
10. 18F]FHBG) : a new potential imaging agent for viral infection and gene therapy using PET Nucl. Med. Biol. 25 175 180
11. 18)F] fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels Eur. J. Nucl. Med. Mol. Imaging 32 257 263
12. P. Goethals M. V. Eijkeren W. Lodewyck R. Dams 1995 Measurement of [methyl-carbon-11]thymidine and its metabolites in head and neck tumors J. Nucl. Med. 36 880 882
13. J. Tjuvajev H. A. Macapinlac F. Daghighian A. M. Scott J. Z. Ginos R. D. Finn P. Kothari R. Desai J. Zhang B. Beattie M. Graham S. M. Larson R. G. Blasberg 1994 Imaging of brain tumor proliferative activity with iodine-131-iododeoxyuridine J. Nucl. Med. 35 407 1417
14. 18F-5-Flourodeoxyuridine in animals Eur. J. Nucl. Med. 8 258 261
15. 18F]flouroethyluracil J. Pharm. Sci. 85 339 344
16. 99m HYNIC-annexin V: a potential radiopharmaceutical for the in-vivo detection of apoptosis Eur. J. Nucl. Med. 26 10 1251 1258
17. 99m l,l-ethylenedicysteine, a new renal imaging agent Eur. J. Nucl. Med. 20 738 746
18. E. P. Canet C. Casali A. Desenfant M. Y. An C. Corot J. F. Obadia D. Revel M. F. Janier 2000 Kinetic characterization of CMD-A2-Gd-DOTA as an intravascular contrast agent for myocardial perfusion measurement with MRI Magn. Reson. Med. 43 403 409
19. 99m DMSA renal cortex scan to detect renal damage in women with type 2 diabetes J. Diabet. Complicat. 17 297 300
20. Y. Li A. E. Martell R. D. Hancock J. H. Reibenspies C. J. Anderson M. J. Welch 1996 N,N′-Ethylenedicysteine (EC) and its metal complexes: synthesis, characterization crystal structures, and equilibrium constants Inorg. Chem. 35 2 404 414
21. 99mTc-Ethylenedicysteinefolate: a new tumor imaging agent. Synthesis, labeling and evaluation in animals Cancer Biother. Radiopharm. 13 427 435
22. 99mTc-ethylenedicysteine- colchicine for evaluation of antiangiogenic effects Anti-cancer Drugs 10 685 692
23. 99mTc-labeled metronidazole Pharm. Res. 16 743 750
24. 99mTc-EC-annexin V Cancer Biother. Radiopharm. 16 73 84
25. 99mTc-EC-endostatin Cancer Biother. Radiopharm. 17 233 246
26. 99mTc- ethylenedicysteine-C225 monoclonal antibody Anti-cancer Drugs 14 49 56
27. 99mTc ECDG targeted at the multifunctional glucose transport system: feasibility study with rodents Radiology 226 465 473
28. 99mTc-labeled metronidazole Stroke 34 982 986
29. Y. Li A. E. Martell R. D. Hancock J. H. Reibenspies C. J. Anderson M. J. Welch 1996 N,N′-Ethylenedi-l-cysteine (EC) and its metal complexes: synthesis, characterization crystal structures, and equilibrium constants Inorg. Chem. 35 2 404 414
30. H. Griengle E. Wanek W. Schwarz W. Streicher B. Rosenwirth E. D. Clercq 1987 2′-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity J. Med. Chem. 30 1199 1204
31. 18F]fluoro-2-deoxy-d-glucose in positron emission tomography for colorectal cancer Eur. J. Nucl. Med. Mol. Imaging 30 988 994
32. S. Uesugi T. Kaneyasu M. Ikehara 1982 Synthesis and properties of ApU analogues containing 2′-halo-2′-deoxyadenosine. Effect of 2′ substituents on oligonucleotide conformation Biochemistry 21 5870 5877
33. L. Malspeis M. R. Grever A. E. Staubus D. Young 1990 Pharmacokinetics of 9-B-arabinofuranosy1-2-fluoroadenine in cancer patients during the phase I clinical investigation of fludarabine phosphate Semin. Oncol. 17 18 32
34. P. Khalili E. Naimi E. E. Knaus L. I. Wiebe 2002 Pharmacokinetics and metabolism of the novel synthetic C-nucleoside, 1-(2-deoxy-beta-d-ribofuranosyl) -2,4-difluoro-5-iodobenzene: a potential mimic of 5-iodo-2′-deoxyuridine Biopharm. Drug Dispos. 23 3 105 113