A novel oscillating bioreactor BelloCell: Implications for insect cell culture and recombinant protein production

Biotechnology Letters

Volumn 27, Issue 15, 2005, Pages 1059-1065

  Lu, Jen Te ^a   Chung, Yao Chi ^a   Chan, Zun Ren ^a   Hu, Yu Chen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

Baculovirus; BelloCell; Immobilization; Packed bed reactor; Protein production

Indexed keywords

CELL CULTURE; CELLS; PROTEINS; REDUCTION;

BACULOVIRUS; BELLOCELL; IMMOBILIZATION; PACKED BED REACTORS; PROTEIN PRODUCTION;

BIOREACTORS;

GREEN FLUORESCENT PROTEIN; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; BACULOVIRUS; BIOREACTOR; CELL COUNT; CELL CULTURE; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; FLUORESCENCE MICROSCOPY; GAS; GENETICS; INSECT; METABOLISM; OSCILLOMETRY; TIME;

ANIMALS; BACULOVIRIDAE; BIOREACTORS; CELL COUNT; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; GASES; GREEN FLUORESCENT PROTEINS; INSECTS; MICROSCOPY, FLUORESCENCE; OSCILLOMETRY; RECOMBINANT PROTEINS; TIME FACTORS;

INSECTA; LEPIDOPTERA; SPODOPTERA FRUGIPERDA;

EID: 24044511187     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-005-8450-3     Document Type: Article

References (11)

1. R Akhnoukh G Kretzmer K Schugerl 1996 On-line monitoring and control of the cultivation of Spodoptera frugiperda Sf9 insect cells and beta-galactosidase production by Autographa californica virus vector Enzyme Microb. Technol 18 220 228
2. S Alauotila A Marjamaki MT Matikainen M Jalkanen 1994 Use of a hollow-fiber bioreactor for large-scale production of alpha 2-adrenoceptors in mammalian cells J. Biotechnol 37 179 184
3. J Archambault J Robert L Tom 1994 Culture of immobilized insect cells Bioprocess Eng 11 189 197
4. C Bedard R Tom A Kamen 1993 Growth, nutrient consumption, and end-product accumulation in Sf-9 and BTI-EAA insect cell cultures: Insights into growth limitation and metabolism Biotechnol. Prog 9 615 624
5. Y-C Hu J Kaufman MW Cho H Golding J Shiloach 2000 Production of HIV-1 gp120 in packed-bed bioreactor using the vaccinia virus/T7 expression system Biotechnol. Prog 16 744 750
6. Y-C Hu J-T Lu Y-C Chung 2003a High-density cultivation of insect cells and production of recombinant baculovirus using a novel oscillating bioreactor Cytotechnology 42 145 153
7. Y-C Hu C-T Tsai Y-J Chang J-H Huang 2003b Enhancement and prolongation of baculovirus-mediated expression in mammalian cells: Focuses on strategic infection and feeding Biotechnol. Prog 19 373 379
8. 2+ binding receptor from HEK 293 cells using perfusion through a packed bed bioreactor Cytotechnology 33 3 11
9. R Kompier N Kislev I Segal A Kadouri 1991 Use of a stationary bed reactor and serum-free medium for the production of recombinant proteins in insect cells Enzyme Microb. Technol 13 822 827
10. AJ Racher JB Griffiths 1993 Investigation of parameters affecting a fixed bed bioreactor process for recombinant cell lines Cytotechnology 13 125 131
11. M Reiter G Bluml T Gaida N Zach F Unterluggauer O Doblhoffdier M Noe R Plail S Huss H Katinger 1991 Modular integrated fluidized-bed bioreactor technology BioTechnology 9 1100 1102