In situ formation of ligand and catalyst - Application in ruthenium-catalyzed enantioselective reduction of ketones

Chemical Communications

Volumn , Issue 32, 2005, Pages 4039-4041

  Västilä, Patrik ^a   Wettergren, Jenny ^a   Adolfsson, Hans ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

KETONE; LIGAND; RUTHENIUM DERIVATIVE;

ARTICLE; CATALYSIS; CHIRALITY; ENANTIOSELECTIVITY; REACTION ANALYSIS; REDUCTION;

EID: 23944519654     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b505516d     Document Type: Article

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32. The proposed structure of catalyst 2 is displayed in Scheme 1. Attempts to isolate and analyze this complex have so far been unsuccessful.
33. 2 gave 1-phenylethanol in merely 29% conversion with 96% ee (S-isomer, reaction time 1 h). See Scheme 1 for the result obtained with ligand 1b.