α-Aminoalkylphosphonates as a tool in experimental optimisation of P1 side chain shape of potential inhibitors in S1 pocket of leucine- and neutral aminopeptidases

European Journal of Medicinal Chemistry

Volumn 40, Issue 8, 2005, Pages 764-771

  Dra̧g, Marcin ^a   Grembecka, Jolanta ^a   Pawełczak, Małgorzata ^b   Kafarski, Paweł ^a  

^a WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

^b UNIVERSITY OF OPOLE   (Poland)

Author keywords

Aminopeptidase N; Aminophosphonates; Inhibitor; Leucine aminopeptidase

Indexed keywords

CYTOSOL AMINOPEPTIDASE; MICROSOMAL AMINOPEPTIDASE; PHOSPHONIC ACID DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG DETERMINATION; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME STRUCTURE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINOPEPTIDASES; ANIMALS; BINDING SITES; HYDROGEN-ION CONCENTRATION; KIDNEY; LEUCINE; LEUCYL AMINOPEPTIDASE; MOLECULAR STRUCTURE; PHOSPHONIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23944516347     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.02.011     Document Type: Article

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