Excess L-arginine restores endothelium-dependent relaxation impaired by monocrotaline pyrrole

Toxicology and Applied Pharmacology

Volumn 207, Issue 3, 2005, Pages 187-194

  Cheng, Wei ^a,b   Oike, Masahiro ^a   Hirakawa, Masakazu ^a   Ohnaka, Keizo ^a   Koyama, Tetsuya ^a   Ito, Yushi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Endothelium; L arginine; Monocrotaline; Nitric oxide; Pulmonary hypertension

Indexed keywords

ACETYLCHOLINE; ARGININE; CALCIUM; COLLAGEN GEL; MONOCROTALINE PYRROLE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; PLANT TOXIN; TRITIUM;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; COW; DRUG LABELING; ENDOTHELIUM; ENDOTHELIUM CELL; EXTRACELLULAR SPACE; HYPOTHESIS; INHIBITION KINETICS; NONHUMAN; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE RELAXATION;

ANIMALS; ARGININE; BLOTTING, WESTERN; CALCIUM; CATTLE; CELL COUNT; CELL SIZE; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; MONOCROTALINE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III;

ANIMALIA; BOVINAE;

EID: 23944506867     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2005.01.002     Document Type: Article

References (32)

1. A.I. Campbell, M.A. Kuliszewski, D.J. Stewart, H.F. Frasch, C. Marshall, B.E. Marshall, R.C. Tyler, M. Muramatsu, S.H. Abman, T.J. Stelzner, D.M. Rodman, K.D. Bloch, and I.F. McMurtry Cell-based gene transfer to the pulmonary vasculature: endothelial nitric oxide synthase overexpression inhibits monocrotaline-induced pulmonary hypertension Am. J. Respir. Cell Mol. Biol. 21 1999 567 575
2. J.H. Chamley, G.R. Campbell, J.D. McConnell, and U. Groschel Stewart Comparison of vascular smooth muscle cells from adult human, monkey and rabbit in primary culture and in subculture Cell Tissue Res. 177 1977 503 522
3. H.C. Champion, T.J. Bivalacqua, S.S. Greenberg, T.D. Giles, A.L. Hyman, and P.J. Kadowitz Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice Proc. Natl. Acad. Sci. U.S.A. 99 2002 13248 13253
4. J. Gianetti, S. Bevilacqua, and R. De Caterina Inhaled nitric oxide: more than a selective pulmonary vasodilator Eur. J. Clin. Invest. 32 2002 628 635
5. T.W. Higenbottam, and E.A. Laude Endothelial dysfunction providing the basis for the treatment of pulmonary hypertension: Giles F. Filley lecture Chest 114 1998 72S 79S
6. K.M. Ito, M. Sato, K. Ushijima, M. Nakai, and K. Ito Alterations of endothelium and smooth muscle function in monocrotaline-induced pulmonary hypertensive arteries Am. J. Physiol. 279 2000 H1786 H1795
7. C. Kimura, T. Koyama, M. Oike, and Y. Ito Hypotonic stress-induced NO production in endothelium depends on endogenous ATP Biochem. Biophys. Res. Commun. 274 2000 736 740
8. C. Kimura, W. Cheng, K. Hisadome, Y.P. Wang, T. Koyama, Y. Karashima, M. Oike, and Y. Ito Superoxide anion impairs contractility in cultured aortic smooth muscle cells Am. J. Physiol. 283 2002 H382 H390
9. C. Kimura, M. Oike, K. Ohnaka, Y. Nose, and Y. Ito Constitutive nitric oxide production in bovine aortic and brain microvascular endothelial cells: a comparative study J. Physiol. (London) 554 2004 721 730
10. S. Kurz, and D.G. Harrison Insulin and the arginine paradox J. Clin. Invest. 99 1997 369 370
11. T.D. Le Cras, D.H. Kim, N.E. Markham, and A.S. Abman Early abnormalities of pulmonary vascular development in the Fawn-Hooded rat raised at Denver's altitude Am. J. Physiol. 279 2000 L283 L291
12. T. Malinski, and Z. Taha Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor Nature 358 1992 676 678
13. R. Mathew, G.A. Zeballos, H. Tun, and M.H. Gewitz Role of nitric oxide and endothelin-1 in monocrotaline-induced pulmonary hypertension in rats Cardiovasc. Res. 30 1995 739 746
14. R. Mathew, N. Yuan, L. Rosenfeld, M.H. Gewitz, and A. Kumar Effects of monocrotaline on endothelial nitric oxide synthase expression and sulfhydryl levels in rat lungs Heart Dis. 4 2002 152 158
15. R. Mathew, J. Huang, M. Shah, K. Patel, M. Gewitz, and P.B. Sehgal Disruption of endothelial-cell caveolin-1α/raft scaffolding during development of monocrotaline-induced pulmonary hypertension Circulation 110 2004 1499 1506
16. A.R. Mattocks, R. Jukes, and J. Brown Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids Toxicon 27 1989 561 567
17. K.K. McDonald, S. Zharikov, E.R. Block, and M.S. Kilberg A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the "arginine paradox" J. Biol. Chem. 272 1997 31213 31216
18. S. Mehta, D.J. Stewart, D. Langleben, and R.D. Levy Short-term pulmonary vasodilation with l-arginine in pulmonary hypertension Circulation 92 1995 1539 1545
19. E.D. Michelakis The role of the NO axis and its therapeutic implications in pulmonary arterial hypertension Heart Failure Rev. 8 2003 5 21
20. L.J. Millatt, G.S. Whitley, D. Li, J.M. Leiper, H.M. Siragy, R.M. Carey, and R.A. Johns Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension Circulation 108 2003 1493 1498
21. R.D. Minshall, W.C. Sessa, R.V. Stan, R.G. Anderson, and A.B. Malik Caveolin regulation of endothelial function Am. J. Physiol.: Lung Cell. Mol. Physiol. 285 2003 L1179 L1183
22. Y. Mitani, K. Maruyama, and M. Sakurai Prolonged administration of l-arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats Circulation 96 1997 689 697
23. S. Moncada, R.M. Palmer, and E.A. Higgs Nitric oxide: physiology, pathophysiology, and pharmacology Pharmacol. Rev. 43 1991 109 142
24. J.F. Reindel, and R.A. Roth The effects of monocrotaline pyrrole on cultured bovine pulmonary artery endothelial and smooth muscle cells Am. J. Pathol. 138 1991 707 719
25. L.J. Rubin Primary pulmonary hypertension N. Engl. J. Med. 336 1997 111 117
26. Shah, M., Patel, K., Sehgal, P.B., in press. Monocrotaline pyrrole-induced endothelial cell megalocytosis involves a Golgi-blockade mechanism. Am. J. Physiol. Cell Physiol.
27. H.C. Thomas, M.W. Lame, D.W. Wilson, and H.J. Segall Cell cycle alterations associated with covalent binding of monocrotaline pyrrole to pulmonary artery endothelial cell DNA Toxicol. Appl. Pharmacol. 141 1996 319 329
28. H.C. Thomas, M.W. Lame, D. Morin, D.W. Wilson, and H.J. Segall Prolonged cell-cycle arrest associated with altered cdc2 kinase in monocrotaline pyrrole-treated pulmonary artery endothelial cells Am. J. Respir. Cell Mol. Biol. 19 1998 129 142
29. D. Tsikas, R.H. Boger, J. Sandmann, S.M. Bode-Boger, and J.C. Frolich Endogenous nitric oxide synthase inhibitors are responsible for the l-arginine paradox FEBS Lett. 478 2000 1 3
30. R.C. Tyler, M. Muramatsu, S.H. Abman, T.J. Stelzner, D.M. Rodman, K.D. Bloch, and I.F. McMurtry Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension Am. J. Physiol. 276 1999 L297 L303
31. 2+ transient in vascular smooth muscle cells in coculture J. Biol. Chem. 271 1996 5647 5655
32. H. Wilkens, A. Guth, J. Konig, N. Forestier, B. Cremers, B. Hennen, M. Bohm, and G.W. Sybrecht Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension Circulation 104 2001 1218 1222