Single mutation at P1 of a chymotrypsin inhibitor changes it to a trypsin inhibitor: X-ray structural (2.15 Å) and biochemical basis

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1752, Issue 1, 2005, Pages 65-72

  Khamrui, Susmita ^a   Dasgupta, Jhimli ^a   Dattagupta, Jiban K ^a   Sen, Udayaditya ^a  

^a SAHA INSTITUTE OF NUCLEAR PHYSICS   (India)

Author keywords

Chymotrypsin inhibitor; Docking studies; Site directed mutagenesis; Specificity change; X ray structure

Indexed keywords

CHYMOTRYPSIN INHIBITOR; TRYPSIN INHIBITOR;

ARTICLE; CHEMICAL ANALYSIS; CONFORMATION; CRYSTAL STRUCTURE; ERYTHRINA; HYDROGEN BOND; INFORMATION; MUTATION; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN FAMILY; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; X RAY ANALYSIS;

AMINO ACID SUBSTITUTION; BASE SEQUENCE; CHYMOTRYPSIN; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEASE INHIBITORS; PROTEIN CONFORMATION; TRYPSIN INHIBITORS; VARIATION (GENETICS);

ERYTHRINA CAFFRA; PSOPHOCARPUS TETRAGONOLOBUS;

EID: 23944503272     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2005.06.012     Document Type: Article

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