Structural biology: Nitrogenase complexes: Multiple docking sites for a nucleotide switch protein

Science

Volumn 309, Issue 5739, 2005, Pages 1377-1380

  Tezcan, F Akif ^a,d   Kaiser, Jens T ^a,b   Mustafi, Debarshi ^a   Walton, Mika Y ^b   Howard, James B ^c   Rees, Douglas C ^a,b  

^a California Institute of Technology   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; AMMONIA; CATALYSIS; COMPLEXATION; CRYSTAL STRUCTURE; ELECTRON TRANSITIONS; ELECTRONS; HYDROLYSIS; PROTEINS;

ADENOSINE TRIPHOSPHATASE (ATPASE); DINITROGEN; MOLECULAR MOTORS; NUCLEOTIDES;

NITROGEN;

ADENOSINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE MAGNESIUM; ADENOSINE TRIPHOSPHATASE; AMMONIA; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROGEN; MOLYBDENUM IRON PROTEIN; NITROGEN; NITROGENASE; NUCLEOTIDE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; DRUG DERIVATIVE; PROTEIN SUBUNIT;

BIOLOGY;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ELECTRON TRANSPORT; HYDROGEN BOND; HYDROLYSIS; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; AZOTOBACTER VINELANDII; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; DIMERIZATION; ENZYMOLOGY; METABOLISM; PHYSICAL CHEMISTRY; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AZOTOBACTER VINELANDII; BINDING SITES; CATALYSIS; CHEMISTRY, PHYSICAL; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ELECTRON TRANSPORT; HYDROGEN BONDING; HYDROLYSIS; MODELS, MOLECULAR; MOLYBDOFERREDOXIN; NITROGENASE; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS;

EID: 23944500884     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1115653     Document Type: Article

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34. This work was supported by the NIH and HHMI. F.A.T. acknowledges the Helen Hay Whitney Foundation for a postdoctoral fellowship. Operations at Stanford Synchrotron Radiation Laboratory and the Advanced Light Source are funded by the Office of Basic Energy Sciences of the U.S. Department of Energy and NIH. We thank the Parsons and Moore Foundations for support of facilities at Caltech. Coordinates and structure factors for .the nf-Av2:Av1, adp-Av2:Av1, and pcp-Av2:Av1 structures have been deposited in the RCSB Protein Data Bank (entries 2AFH, 2AFI, and 2AFK, respectively) for release upon publication.