Fractalkine gene therapy for neuroblastoma is more effective in combination with targeted IL-2

Cancer Letters

Volumn 228, Issue 1-2, 2005, Pages 187-193

  Zeng, Yan ^a   Jiang, Jikai ^a   Huebener, Nicole ^a   Wenkel, Jens ^a   Gaedicke, Gerhard ^a   Xiang, Rong ^b   Lode, Holger N ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Ch14.18 IL 2; Fractalkine; GD2; Gene therapy; Immunotherapy; Neuroblastoma

Indexed keywords

FRACTALKINE; GANGLIOSIDE ANTIBODY; GANGLIOSIDE GD2 ANTIBODY; INTERLEUKIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER ADJUVANT THERAPY; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; METASTASIS; MOUSE; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; RNA TRANSLATION; SHORT SURVEY; TREATMENT OUTCOME;

MURINAE;

EID: 23944494575     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.01.057     Document Type: Review

References (12)

1. C. Gerard, and B.J. Rollins Chemokines and disease Nat. Immunol. 2 2001 108 115
2. J.F. Bazan, K.B. Bacon, G. Hardiman, W. Wang, K. Soo, and D. Rossi A new class of membrane-bound chemokine with a CX3C motif Nature 385 1997 640 644
3. Y. Pan, C. Lloyd, H. Zhou, S. Dolich, J. Deeds, and J.A. Gonzalo Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation Nature 387 1997 611 617
4. M. Matloubian, A. David, S. Engel, J.E. Ryan, and J.G. Cyster A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo Nat. Immunol. 1 2000 298 304
5. A.M. Fong, L.A. Robinson, D.A. Steeber, T.F. Tedder, O. Yoshie, and T. Imai Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow J. Biol. Chem. 188 1998 1413 1419
6. P. Fraticelli, M. Sironi, G. Bianchi, D. D'Ambrosio, C. Albanesi, and A. Stoppacciaro Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses J. Clin. Invest. 107 2001 1173 1181
7. O. Yoneda, T. Imai, M. Nishimura, M. Miyaji, T. Mimori, and T. Okazaki Membrane-bound form of fractalkine induces IFN-gamma production by NK cells Eur. J. Immunol. 33 2003 53 58
8. T. Imai, K. Hieshima, C. Haskell, M. Baba, M. Nagira, and M. Nishimura Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion Cell 91 1997 521 530
9. J.D. Pancook, J.C. Becker, S.D. Gillies, and R.A. Reisfeld Eradication of established hepatic human neuroblastoma metastases in mice with severe combined immunodeficiency by antibody-targeted interleukin-2 Proc. Natl Acad. Sci. USA 42 1996 88 92
10. H.N. Lode, R. Xiang, S.R. Duncan, A.N. Theofilopoulos, S.D. Gillies, and R.A. Reisfeld Tumor-targeted IL-2 amplifies T cell-mediated immune response induced by gene therapy with single-chain IL-12 Proc. Natl Acad. Sci. USA 96 1999 8591 8596
11. H.N. Lode, R. Xiang, N.M. Varki, C.A. Dolman, S.D. Gillies, and R.A. Reisfeld Targeted interleukin-2 therapy for spontaneous neuroblastoma metastases to bone marrow J. Natl Cancer Inst. 89 1997 1586 1594
12. D. Dilloo, K. Bacon, W. Holden, W. Zhong, S. Burdach, and A. Zlotnik Combined chemokine and cytokine gene transfer enhances antitumor immunity Nat. Med. 2 1996 1090 1095