Chemoprotective effects of captopril against cyclophosphamide-induced genotoxicity in mouse bone marrow cells

Archives of Toxicology

Volumn 79, Issue 8, 2005, Pages 482-486

  Hosseinimehr, S J ^a   Karami, M ^a  

^a MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Captopril; Chemoprotection; Cyclophosphamide; Glutathione; Micronucleus

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; CAPTOPRIL; CYCLOPHOSPHAMIDE; FREE RADICAL; GLUTATHIONE; SCAVENGER; THIOL;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DRUG EFFECT; ERYTHROCYTE; GENOTOXICITY; LIVER; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIMUTAGENIC AGENTS; ANTIOXIDANTS; BONE MARROW CELLS; CAPTOPRIL; CHEMOPREVENTION; CYCLOPHOSPHAMIDE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROBLASTS; GLUTATHIONE; INJECTIONS, INTRAPERITONEAL; LIVER; MALE; MICE; MICE, INBRED STRAINS; MICRONUCLEUS TESTS; MUTAGENS;

EID: 23944493409     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-005-0655-7     Document Type: Article

References (26)

1. Abd El-Aziz MA, Amer AL, El-Missiry MA (2001) Potential protective role of angiotensin-converting enzyme inhibitors captopril and enalapril against adriamycin-induced acute cardiac and hepatic toxicity in rats. Appl Toxicol 21:469-473
2. Anderson ME (1998) Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact 111-112:1-14
3. Bartosz M, Kedziora J, Bartosz G (1997) Antioxidant and prooxidant properties of captopril and enalapril. Free Radic Biol Med 23:729-735
4. Blasiak J, Gloc E, Wozniak K, Mlynarski W, Stolarska M (2002) Genotoxicity of idarubicin and its modulation by vitamins C and E and amifostine. Chem Biol Interact 140:1-18
5. Brookes P (1990) The early history of the biological alkylating agents. Mutat Res 233:3-14
6. Cavanagh EMD, Inserra F, Ferder L (2002) Enalaperil and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues. Am J Physiol Regul Integr Comp Physiol 278:572-577
7. Donnerstag B, Ohlenschlager B, Cinatle J (1996) Reduced glutathione and 5-acetylglutathione as selective apoptosis-inducing agents in cancer therapy. Cancer Lett 110:63-70
8. Fraiser LH, Kanekal S, Kehrer JP (1991) Cyclophosphamide toxicity. Drugs 42:781-795
9. Griggs JJ (1998) Reducing the toxicity of anticancer therapy: new strategies. Leuk Res 22:27-33
10. Hosseinimehr SJ, Tavakoli H, Pourheidary GR (2003) Radioprotective effects of citrus extract against gamma irradiation in mouse bone marrow cells. J Radiat Res 44:273-241
11. Jay D, Garcia EJ, Aviala MC, Munoz E (2002) Superoxide-superoxide oxidoreductase activity of the captopril-copper complex. Arch Med Res 33:115-122
12. Koleva I, Van Beek TA, Linssen JPH (2002) Screening of plant extracts for antioxidant activity: a comparative study on three testing methods. Phytochem Anal 13:8-17
13. Kowalski J, Herman ZS (1996) Captopril augments antitumor activity of cyclophosphamide in mice. Pol J Pharmacol 48:281-285
14. Lapenna D, De Gioia S, Mezzetti A, Ciofani G, Di Ilio C, Cuccurullo F (1995) The prooxidant properties of captopril. Biochem Pharmacol 50:27-32
15. Manda K, Bhatia AL (2003) Prophylactic action of melatonin against cyclophosphamide-induced oxidative stress in mice. Cell Biol Toxicol 19:367-372
16. Mavournin KH, Cimino DH, Salamone MF, Heddle JA (1990) The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of US Environmental Protection Agency Gene-Tox Program. Mutat Res 239:29-80
17. Mazur L, Blawat A (1999) Effects of GSH and WR-2721 on induction of micronuclei by cyclophosphamide. Toxicol Lett 110:67-72
18. Moore MJ (1991) Clinical pharmacokinetics of cyclophosphamide. Clin Pharmacokinet 20:194-208
19. Muller MJ, Streffer C (1994) Micronucleus assay. In: Obe G (ed) Advances in mutagenesis research, vol 5. Springer, Berlin Heidelberg New York, pp 4-134
20. Rompelberg CJM, Stenhuis WH, de Vogel N, Vonosenbruggen WA (1995) Antimutagenicity of eugenol in the rodent bone marrow micronucleus test. Mutat Res 346:69-75
21. Schmid W (1975) The micronucleus test. Mutat Res 31:9-15
22. Sedlak J, Lindsay RH (1968) Estimation of total protein with bound and non-protein sulfhydryl groups in tissues with Ellman's reagent. Anal Biochem 25:192-205
23. Stewart FA (1989) Modification of normal tissue response to radiotherapy and chemotherapy. Int J Radiat Oncol Biol Phys 16:1195-1200
24. Tiwari AK (2001) Imbalance in antioxidant defense and human diseases: multiple approach of natural antioxidants therapy. Curr Sci 81:1179-1187
25. Van der Vijgh WJF, Peters GJ (1994) Protection of normal tissues from cytotoxic effects of chemotherapy and radiation by Amifostine (Ethyol): preclinical aspects. Semin Oncol 21:2-7
26. Vijayalaxmi KK, Venu R (1999) In vivo anticlastogenic effects of L-ascorbic acid in mice. Mutat Res 438:47-51