The search for effective HIV vaccines

New England Journal of Medicine

Volumn 353, Issue 8, 2005, Pages 753-757

  Markel, Howard ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Center for the History of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANTIDEPRESSANT AGENT; DNA VACCINE; HEPATITIS B VACCINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INFLUENZA VACCINE; LIVE VACCINE; MEASLES VACCINE; PERTUSSIS VACCINE; POLIOMYELITIS VACCINE; TYPHOID VACCINE; VIRUS VECTOR; GLYCOPROTEIN GP 120; VIRUS ENVELOPE PROTEIN;

CANARYPOX VIRUS; CELLULAR IMMUNITY; CLINICAL TRIAL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNE RESPONSE; MEDICAL RESEARCH; PRIORITY JOURNAL; REVIEW; SEXUAL TRANSMISSION; VIRUS REPLICATION; ANIMAL; ARTICLE; DRUG INDUSTRY; ECONOMICS; EPIDEMIC; GENETICS; HISTORY; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOLOGY; PATHOGENICITY;

AIDS VACCINES; ANIMALS; CLINICAL TRIALS; DISEASE OUTBREAKS; DRUG INDUSTRY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HIV; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HUMANS; VIRAL ENVELOPE PROTEINS;

EID: 23944491679     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMp058146     Document Type: Review

References (5)

1. Shilts R. And the band played on: politics, people, and the AIDS epidemic. New York: St. Martin's Press, 1987:451.
2. Mattapallil JJ, Douek DC, Hill B, Nishimura Y, Martin M, Roederer M. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 2005;434:1093-7.
3. Li Q, Duan L, Estes JD, et al. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 2005;434:1148-52.
4. Mehandru S, Poles MA, Tenner-Racz K, et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 2004;200:761-70.
5. Brenchley JM, Schacker TW, Ruff LE, et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004;200:749-59.