Characterization of amino acid variation at strategic positions in parasite and human proteases for selective inhibition of falcipains in Plasmodium falciparum

Biochemical and Biophysical Research Communications

Volumn 335, Issue 3, 2005, Pages 762-770

  Liuh, Ling Goh ^a   Sim, Tiow Suan ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Biochemical characterization; Falcipain; Homology modeling; Rational drug design; Site directed mutagenesis

Indexed keywords

AMINO ACID; CATHEPSIN L; FALCIPAIN; MUTANT PROTEIN; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PEPSTATIN; PROTEINASE; PROTEINASE INHIBITOR; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

AMINO ACID ANALYSIS; ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; DRUG SCREENING; ENZYME INACTIVATION; ENZYME SPECIFICITY; ERYTHROCYTE; GENE MAPPING; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MOLECULAR INTERACTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN CALORIE MALNUTRITION; PROTEIN FAMILY; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHROMATOGRAPHY, GEL; CLONING, MOLECULAR; CYSTEINE ENDOPEPTIDASES; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE HYDROLASES; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; TRANSCRIPTION, GENETIC;

PLASMODIUM FALCIPARUM;

EID: 23944479731     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.07.147     Document Type: Article

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