Topical application of morphine gel in inflammatory mucosal and cutaneous lesions;Topische applikation von morphingel bei entzündlichen haut- und schleimhautläsionen

Schmerz

Volumn 19, Issue 4, 2005, Pages 296-301

  Platzer, M ^a   Likar, R ^a   Stein, C ^b   Beubler, E ^c   Sittl, R ^d  

^a GENERAL HOSPITAL KLAGENFURT   (Austria)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF GRAZ   (Austria)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Inflammatory skin mucosal lesions; Morphine gel; Peripheral opioid receptor

Indexed keywords

MORPHINE;

ARTICLE; DRUG EFFECT; DRUG FORMULATION; GENITAL PAIN; HUMAN; MUCOSA INFLAMMATION; PAIN ASSESSMENT; SKIN DEFECT; SKIN ULCER;

ADMINISTRATION, TOPICAL; ADULT; AGED; ANALGESICS, OPIOID; FEMALE; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; MORPHINE; MUCOUS MEMBRANE; SKIN DISEASES; SKIN ULCER;

EID: 23944479726     PISSN: 0932433X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00482-004-0372-9     Document Type: Article

References (15)

1. Antonijevic I, Mousa SA, Schäfer M, Stein C (1995) Perineural defect and peripheral opioid analgesia in inflammation. J Neurosci 15:165-172
2. Cerchietti LC, Navigante AH, Bonomi MR, Zaderajko MA, Menendez PR, Pogany CE, Roth BM (2002) Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. Cancer 95(10):2230-2236
3. Flock P (2003) Pilot study to determine the effectiveness of diamorphine gel to control pressure ulcer pain. J Pain Symptom Manage 25 (6):547-554
4. Kalso E, Smith L, McQuay HJ, Moore RA (2002) No pain, no gain: clinical excellence and scientific rigour-lessons learned from IA morphine. Pain 98 (3):269-275
5. Krajnik M, Zylicz Z, Finaly I, Luczak J, van Sorge AA (1999) Potential uses of topical opioids in palliative care-report of 6 cases. Pain 80:121-125
6. Likar R, Koppert W, Blatnig H, Chiari F, Sittl R, Stein C et al. (2001) Efficacy of peripheral morphine analgesia in inflamed, non-inflamed and perineural tissue of dental surgery patients. J Pain Symptom Manage 21:330-337
7. Ramesh PR, Santhosh AR, Kumar KS (1998) Topical morphinein Ayurveda. Palliat Med 12:64
8. Selley DE, Breivogel CS, Childers SR (1993) Modification of G protein-coupled functions by low-pH pretreatments of membranes from NG108-15 cells: increase in opioid agonist efficacy by decreased inervation of G proteins. Mol Pharmacol 44:731-741
9. Stein C (1995) The control of pain in peripheral tissue by opioids. N Engl J Med 332:1685-1690
10. Stein C, Schäfer M, Machelska H (2003) Attacking pain at its source: new perspectives on opioids. Nature Med 9 (8):1003-1008
11. Stiles J, Honda CN, Krohne SG, Kazacos EA (2003) Effect of topical administration of 1% morphine sulfate solution on signs of pain and corneal wound healing in dogs. Am J Vet Res 64 (7):813-818
12. Twillman RK, Long TD, Cathers TA, Mueller DW (1999) Treatment of painful skin ulcers with topical opioids. J Pain Symptom Manage 17 (4):288-292
13. Wenk HN, Nannenga MN, Honda CN (2003) Effect of morphine sulphate eye drops on hyperalgesia in the rat cornea. Pain 105 (3):455-465
14. Zeppetella G, Paul J, Ribeiro MDC (2003) Analgesic efficacy of morphine applied topically to painful ulcers. J Pain Symptom Manage 25 (6):555-558
15. Zöllner C, Shaqura MA, Bopaiah CR Mousa S, Stein C, Schafer M (2003) Painful inflammation-induced increase in mu-opioid receptor binding and G-protein coupling in primary afferent neurons. Mol Pharmacol 64 (2):202-210