External mechanical force as an inhibition process in kinesin's motion

Biochemical Journal

Volumn 390, Issue 1, 2005, Pages 345-349

  Ciudad, Aleix ^a   Sancho, José María ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Inhibition process; Kinesin dynamics; Load dependence; Mechanical force; Molecular motor

Indexed keywords

BIOCHEMISTRY; KINETIC THEORY; PROTEINS;

INHIBITION PROCESSES; KINESIN DYNAMICS; LOAD DEPENDENCE; MECHANICAL FORCE; MOLECULAR MOTOR;

ADENOSINETRIPHOSPHATE;

ADENOSINE TRIPHOSPHATE; KINESIN; MOLECULAR MOTOR;

ANALYTIC METHOD; ARTICLE; FORCE; MATHEMATICAL ANALYSIS; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL; TURNOVER TIME; VELOCITY;

ADENOSINE TRIPHOSPHATE; BIOMECHANICS; KINESIN; KINETICS; MODELS, BIOLOGICAL; MOLECULAR MOTOR PROTEINS; PRESSURE;

EID: 23944471142     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20042092     Document Type: Article

References (14)

1. Schnitzer, M. J. and Block, S. M. (1997) Kinesin hydrolyses one ATP per 8-nm step. Nature (London) 388, 386-390
2. Visscher, K., Schnitzer, M. J. and Block, S. M. (1999) Single kinesin molecules studied with a molecular force clamp. Nature (London) 400, 184-189
3. Dixon, M. and Webb, E. C. (1979) Enzyme inhibition and activation. In Enzymes, 3rd edn. (Dixon, M., Webb, E. C., Thorne, C. J. R. and Tipton, K. F., eds.), pp. 332-467, Longman, London
4. Palmer, T. (1995) Understanding enzymes, 4th edn., Prentice Hall/Ellis Horwood, London
5. Schnitzer, M. J., Visscher, K. V. and Block, S. M. (2000) Force production by single kinesin motors. Nat. Cell Biol. 2, 718-723
6. Fisher, M. E. and Kolomeisky, A. B. (2001) Simple mechanochemistry describes the dynamics of kinesin molecules. Proc. Natl. Acad. Sci. U.S.A. 98, 7748-7753
7. Jülicher, F., Ajdari, A. and Prost, J. (1997) Modelling molecular motors. Rev. Mod. Phys. 69, 1269-1281
8. Howard, J. (1997) Molecular motors: structural adaptations to cellular functions. Nature (London) 389, 561-567
9. Svoboda, K and Block, S. M. (1994) Force and velocity measured for single kinesin molecules. Cell 77, 773-784
10. Coppin, C. M., Pierce, D. W., Hsu, L. and Vale, R. D. (1997) The load dependence of kinesin's mechanical cycle. Proc. Natl. Acad. Sci. U.S.A. 94, 8539-8544
11. Howard, J., Hudspeth, A. J. and Vale, R. D. (1989) Movement of microtubules by single kinesin molecules. Nature (London) 342, 154-158
12. Bustamante, C., Chemla, Y. R., Forde, N. R. and Izhaky, D. (2004) Mechanical processes in biochemistry. Annu. Rev. Biochem. 73, 705-748
13. Cortés, A., Cascante, M., Cárdenas, M. L. and Cornish-Bowden, A. (2001) Relationships between inhibition constants, inhibitor concentrations for 50% inhibition and types of inhibition: new ways of analysing data. Biochem. J. 357, 263-268
14. Block, S. M., Asbury, C. L., Shaevitz, J. W. and Lang, M. J. (2003) Probing the kinesin reaction cycle with a 2D optical force clamp. Proc. Natl. Acad. Sci. U.S.A. 100, 2351-2356