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Volumn 32, Issue 4, 2005, Pages 218-223

Randomized placebo-controlled trial of interferon alpha-2b plus ribavirin with and without lactoferrin for chronic hepatitis C

Author keywords

Chronic hepatitis C; Interferon alpha 2b; Lactoferrin; Ribavirin

Indexed keywords

ALANINE AMINOTRANSFERASE; FERRITIN; HEMOGLOBIN; IRON; LACTOFERRIN; PLACEBO; RECOMBINANT ALPHA2B INTERFERON; RIBAVIRIN; VIRUS RNA;

EID: 23944467709     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hepres.2005.03.018     Document Type: Article
Times cited : (24)

References (41)
  • 2
    • 17144440527 scopus 로고    scopus 로고
    • Close association between high serum ALT and more rapid recurrence of hepatocellular carcinoma in hepatectomized patients with HCV-associated liver cirrhosis and hepatocellular carcinoma
    • K. Tarao Y. Rino S. Takemiya et al. Close association between high serum ALT and more rapid recurrence of hepatocellular carcinoma in hepatectomized patients with HCV-associated liver cirrhosis and hepatocellular carcinoma Intervirology 43 2000 20-26
    • (2000) Intervirology , vol.43 , pp. 20-26
    • Tarao, K.1    Rino, Y.2    Takemiya, S.3
  • 3
    • 17344369924 scopus 로고    scopus 로고
    • Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C
    • Osaka Liver Disease Study Group
    • A. Kasahara N. Hayashi K. Mochizuki et al. Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Osaka Liver Disease Study Group Hepatology 27 1998 1394-1402
    • (1998) Hepatology , vol.27 , pp. 1394-1402
    • Kasahara, A.1    Hayashi, N.2    Mochizuki, K.3
  • 4
    • 17144455384 scopus 로고    scopus 로고
    • Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy
    • Y. Shiratori F. Imazeki M. Moriyama et al. Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy Ann Intern Med 132 2000 517-524
    • (2000) Ann. Intern. Med. , vol.132 , pp. 517-524
    • Shiratori, Y.1    Imazeki, F.2    Moriyama, M.3
  • 5
    • 0030931156 scopus 로고    scopus 로고
    • Hepatitis C and hepatocellular carcinoma
    • A.M. Di Bisceglie Hepatitis C and hepatocellular carcinoma Hepatology 26 Suppl. 1 1997 34S-38S
    • (1997) Hepatology , vol.26 , Issue.SUPPL. 1
    • Di Bisceglie, A.M.1
  • 6
    • 0028961434 scopus 로고
    • Incidence of hepatocellular carcinoma in chronic hepatitis B and C: A prospective study of 251 patients
    • S. Takano O. Yokosuka F. Imazeki M. Tagawa M. Omata Incidence of hepatocellular carcinoma in chronic hepatitis B and C: A prospective study of 251 patients Hepatology 21 1995 650-655
    • (1995) Hepatology , vol.21 , pp. 650-655
    • Takano, S.1    Yokosuka, O.2    Imazeki, F.3    Tagawa, M.4    Omata, M.5
  • 7
    • 17344370538 scopus 로고    scopus 로고
    • Prognosis of chronic hepatitis C: Results of a large, prospective cohort study
    • C. Niederau S. Lange T. Heintges et al. Prognosis of chronic hepatitis C: Results of a large, prospective cohort study Hepatology 28 1998 1687-1695
    • (1998) Hepatology , vol.28 , pp. 1687-1695
    • Niederau, C.1    Lange, S.2    Heintges, T.3
  • 8
    • 0032547938 scopus 로고    scopus 로고
    • Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
    • J.G. McHutchison S.C. Gordon E.R. Schiff et al. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C N Engl J Med 339 1998 1485-1492
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1485-1492
    • McHutchison, J.G.1    Gordon, S.C.2    Schiff, E.R.3
  • 9
    • 0032547944 scopus 로고    scopus 로고
    • Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C
    • G.L. Davis R. Esteban-Mur V. Rustgi et al. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C N Engl J Med 339 1998 1493-1499
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1493-1499
    • Davis, G.L.1    Esteban-Mur, R.2    Rustgi, V.3
  • 10
    • 0032501714 scopus 로고    scopus 로고
    • Randomised, double-blind, placebo-controlled trial of interferon alpha-2b with and without ribavirin for chronic hepatitis C
    • The Swedish Study Group
    • O. Reichard G. Norkrans A. Fryden J.H. Braconier A. Sonnerborg O. Weiland Randomised, double-blind, placebo-controlled trial of interferon alpha-2b with and without ribavirin for chronic hepatitis C. The Swedish Study Group Lancet 351 1998 83-87
    • (1998) Lancet , vol.351 , pp. 83-87
    • Reichard, O.1    Norkrans, G.2    Fryden, A.3    Braconier, J.H.4    Sonnerborg, A.5    Weiland, O.6
  • 11
    • 15044353027 scopus 로고    scopus 로고
    • Prediction of treatment outcome with daily high-dose IFN α-2b plus ribavirin in patients with chronic hepatitis C with genotype 1b and high HCV RNA levels: Relationship of baseline viral levels and viral dynamics during and after therapy
    • S. Iino E. Tomita H. Kumada et al. Prediction of treatment outcome with daily high-dose IFN α-2b plus ribavirin in patients with chronic hepatitis C with genotype 1b and high HCV RNA levels: Relationship of baseline viral levels and viral dynamics during and after therapy Hepatol Res 30 2004 63-70
    • (2004) Hepatol. Res. , vol.30 , pp. 63-70
    • Iino, S.1    Tomita, E.2    Kumada, H.3
  • 12
    • 0029130333 scopus 로고
    • Lactoferrin: Molecular structure and biological function
    • B. Lonnerdal S. Iyer Lactoferrin: Molecular structure and biological function Annu Rev Nutr 15 1995 93-110
    • (1995) Annu. Rev. Nutr. , vol.15 , pp. 93-110
    • Lonnerdal, B.1    Iyer, S.2
  • 13
    • 0029126185 scopus 로고
    • Lactoferrin: A general review
    • P.F. Levay M. Viljoen Lactoferrin: A general review Haematologica 80 1995 252-267
    • (1995) Haematologica , vol.80 , pp. 252-267
    • Levay, P.F.1    Viljoen, M.2
  • 15
    • 0028890512 scopus 로고
    • Lactoferrin inhibits herpes simplex virus type-1 (HSV-1) infection to mouse cornea
    • T. Fujihara K. Hayashi Lactoferrin inhibits herpes simplex virus type-1 (HSV-1) infection to mouse cornea Arch Virol 140 1995 1469-1472
    • (1995) Arch. Virol. , vol.140 , pp. 1469-1472
    • Fujihara, T.1    Hayashi, K.2
  • 16
    • 0029297892 scopus 로고
    • Impairment of circulating lactoferrin in HIV-1 infection
    • M.C. Defer B. Dugas O. Picard C. Damais Impairment of circulating lactoferrin in HIV-1 infection Cell Mol Biol 41 1995 417-421
    • (1995) Cell Mol. Biol. , vol.41 , pp. 417-421
    • Defer, M.C.1    Dugas, B.2    Picard, O.3    Damais, C.4
  • 17
    • 0029080953 scopus 로고
    • Antiviral effects of plasma and milk proteins: Lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro
    • M.C. Harmsen P.J. Swart M.P. de Bethune et al. Antiviral effects of plasma and milk proteins: Lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro J Infect Dis 172 1995 380-388
    • (1995) J. Infect. Dis. , vol.172 , pp. 380-388
    • Harmsen, M.C.1    Swart, P.J.2    de Bethune, M.P.3
  • 18
    • 0032540093 scopus 로고    scopus 로고
    • Lactoferrin markedly inhibit hepatitis C virus infection in cultured human hepatocytes
    • M. Ikeda K. Sugiyama T. Tanaka et al. Lactoferrin markedly inhibit hepatitis C virus infection in cultured human hepatocytes Biochem Biophys Res Commun 245 1998 549-553
    • (1998) Biochem. Biophys. Res. Commun. , vol.245 , pp. 549-553
    • Ikeda, M.1    Sugiyama, K.2    Tanaka, T.3
  • 19
    • 0030740063 scopus 로고    scopus 로고
    • Hepatitis C virus envelope proteins bind lactoferrin
    • M. Yi S. Kaneko D.Y. Yu S. Murakami Hepatitis C virus envelope proteins bind lactoferrin J Virol 71 1997 5997-6002
    • (1997) J. Virol. , vol.71 , pp. 5997-6002
    • Yi, M.1    Kaneko, S.2    Yu, D.Y.3    Murakami, S.4
  • 20
    • 0033956354 scopus 로고    scopus 로고
    • Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells
    • M. Ikeda A. Nozaki K. Sugiyama et al. Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells Virus Res 66 2000 51-63
    • (2000) Virus Res. , vol.66 , pp. 51-63
    • Ikeda, M.1    Nozaki, A.2    Sugiyama, K.3
  • 21
    • 0036127867 scopus 로고    scopus 로고
    • Lactoferrin inhibits hepatitis C virus viremia in chronic hepatitis C patients with high viral loads and HCV genotype 1b
    • M. Iwasa M. Kaito J. Ikoma et al. Lactoferrin inhibits hepatitis C virus viremia in chronic hepatitis C patients with high viral loads and HCV genotype 1b Am J Gasrtoenterol 97 2002 766-767
    • (2002) Am. J. Gasrtoenterol. , vol.97 , pp. 766-767
    • Iwasa, M.1    Kaito, M.2    Ikoma, J.3
  • 22
    • 0032962172 scopus 로고    scopus 로고
    • Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: A pilot study
    • K. Tanaka M. Ikeda A. Nozaki et al. Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: A pilot study Jpn J Cancer Res 90 1999 367-371
    • (1999) Jpn. J. Cancer Res. , vol.90 , pp. 367-371
    • Tanaka, K.1    Ikeda, M.2    Nozaki, A.3
  • 23
    • 0036747346 scopus 로고    scopus 로고
    • Dose-response trial of lactoferrin in patients with chronic hepatitis C
    • S. Okada K. Tanaka T. Sato et al. Dose-response trial of lactoferrin in patients with chronic hepatitis C Jpn J Cancer Res 93 2002 1063-1069
    • (2002) Jpn. J. Cancer Res. , vol.93 , pp. 1063-1069
    • Okada, S.1    Tanaka, K.2    Sato, T.3
  • 24
    • 0038410193 scopus 로고    scopus 로고
    • Long-term follow-up of chronic hepatitis C patients treated with oral lactoferrin for 12 months
    • K. Ishii N. Takamura M. Shinohara et al. Long-term follow-up of chronic hepatitis C patients treated with oral lactoferrin for 12 months Hepatol Res 25 2003 226-233
    • (2003) Hepatol. Res. , vol.25 , pp. 226-233
    • Ishii, K.1    Takamura, N.2    Shinohara, M.3
  • 25
    • 2342646131 scopus 로고    scopus 로고
    • A randomized controlled trial of consensus interferon with or without lactoferrin for chronic hepatitis C patients with genotype 1b and high viral load
    • N. Hirashima E. Orito K. Ohba et al. A randomized controlled trial of consensus interferon with or without lactoferrin for chronic hepatitis C patients with genotype 1b and high viral load Hepatol Res 29 2004 9-12
    • (2004) Hepatol. Res. , vol.29 , pp. 9-12
    • Hirashima, N.1    Orito, E.2    Ohba, K.3
  • 27
    • 0026777128 scopus 로고
    • HCV genotypes in chronic hepatitis C and response to interferon
    • K. Kanai M. Kako H. Okamoto HCV genotypes in chronic hepatitis C and response to interferon Lancet 339 1992 1543
    • (1992) Lancet , vol.339 , pp. 1543
    • Kanai, K.1    Kako, M.2    Okamoto, H.3
  • 28
    • 0028204083 scopus 로고
    • Related articles, links abstract factors predictive of response to interferon-alpha therapy in hepatitis C virus infection
    • A. Tsubota K. Chayama K. Ikeda et al. Related articles, links abstract factors predictive of response to interferon-alpha therapy in hepatitis C virus infection Hepatology 19 1994 1088-1094
    • (1994) Hepatology , vol.19 , pp. 1088-1094
    • Tsubota, A.1    Chayama, K.2    Ikeda, K.3
  • 29
    • 0028263211 scopus 로고
    • Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C
    • K. Hino S. Sainokami K. Shimoda et al. Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C J Med Virol 42 1994 299-305
    • (1994) J. Med. Virol. , vol.42 , pp. 299-305
    • Hino, K.1    Sainokami, S.2    Shimoda, K.3
  • 30
    • 0028947744 scopus 로고
    • Predictive factors in the response to interferon therapy in chronic hepatitis C
    • K. Yoshioka Y. Higashi M. Yamada et al. Predictive factors in the response to interferon therapy in chronic hepatitis C Liver 15 1995 57-62
    • (1995) Liver , vol.15 , pp. 57-62
    • Yoshioka, K.1    Higashi, Y.2    Yamada, M.3
  • 31
    • 0032032484 scopus 로고    scopus 로고
    • A pilot randomized, controlled trial of the effect of iron depletion on long-term response to alpha-interferon in patients with chronic hepatitis C
    • T.L. Fong S.H. Han N.C. Tsai et al. A pilot randomized, controlled trial of the effect of iron depletion on long-term response to alpha-interferon in patients with chronic hepatitis C J Hepatol 28 1998 369-374
    • (1998) J. Hepatol. , vol.28 , pp. 369-374
    • Fong, T.L.1    Han, S.H.2    Tsai, N.C.3
  • 32
    • 0028915570 scopus 로고
    • Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C
    • J.K. Olynyk K.R. Reddy A.M. Di Bisceglie et al. Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C Gastroenterology 108 1995 1104-1109
    • (1995) Gastroenterology , vol.108 , pp. 1104-1109
    • Olynyk, J.K.1    Reddy, K.R.2    Di Bisceglie, A.M.3
  • 34
    • 0028824335 scopus 로고
    • Elevated serum iron predicts poor response to interferon treatment in patients with chronic HCV infection
    • N. Arber M. Moshkowitz F. Konikoff et al. Elevated serum iron predicts poor response to interferon treatment in patients with chronic HCV infection Dig Dis Sci 40 1995 2431-2433
    • (1995) Dig. Dis. Sci. , vol.40 , pp. 2431-2433
    • Arber, N.1    Moshkowitz, M.2    Konikoff, F.3
  • 36
    • 0028929335 scopus 로고
    • Distribution of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy
    • A.L. Barton B.F. Banner E.E. Cable H.L. Bonkovsky Distribution of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy Am J Clin Pathol 103 1995 419-424
    • (1995) Am. J. Clin. Pathol. , vol.103 , pp. 419-424
    • Barton, A.L.1    Banner, B.F.2    Cable, E.E.3    Bonkovsky, H.L.4
  • 37
    • 17544383347 scopus 로고    scopus 로고
    • Iron reduction before and during interferon therapy of chronic hepatitis C: Results of a multicenter, randomized, controlled trial
    • R.J. Fontana J. Israel P. LeClair et al. Iron reduction before and during interferon therapy of chronic hepatitis C: Results of a multicenter, randomized, controlled trial Hepatology 31 2000 730-736
    • (2000) Hepatology , vol.31 , pp. 730-736
    • Fontana, R.J.1    Israel, J.2    LeClair, P.3
  • 39
    • 0028318340 scopus 로고
    • Improvement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron
    • H. Hayashi T. Takikawa N. Nishimura M. Yano T. Isomuar Sakomoto Improvement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron Am J Gastroenterol 89 1994 986-988
    • (1994) Am. J. Gastroenterol. , vol.89 , pp. 986-988
    • Hayashi, H.1    Takikawa, T.2    Nishimura, N.3    Yano, M.4    Isomuar, T.5    Sakomoto6
  • 40
    • 0029330270 scopus 로고
    • Iron and chronic viral hepatitis: Emerging evidence for an important interaction
    • R.B. Rubin A. Barton B.F. Banner H.L. Bonkovsky Iron and chronic viral hepatitis: Emerging evidence for an important interaction Dig Dis 13 1995 223-238
    • (1995) Dig. Dis. , vol.13 , pp. 223-238
    • Rubin, R.B.1    Barton, A.2    Banner, B.F.3    Bonkovsky, H.L.4
  • 41
    • 0036213973 scopus 로고    scopus 로고
    • Intracellular cytokine analysis of CD4-positive T cells predictive of sustained response to interferon therapy for patients with chronic hepatitis C
    • K. Ishii N. Takamura M. Shinohara et al. Intracellular cytokine analysis of CD4-positive T cells predictive of sustained response to interferon therapy for patients with chronic hepatitis C Dig Dis Sci 47 2002 778-783
    • (2002) Dig. Dis. Sci. , vol.47 , pp. 778-783
    • Ishii, K.1    Takamura, N.2    Shinohara, M.3


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