-
1
-
-
0024805768
-
DNA-intercalating ligands as anti-cancer drugs: Prospects for future design
-
Denny, W. A. DNA-intercalating ligands as anti-cancer drugs: prospects for future design. Anti-Cancer Drug Des. 1989, 4, 241-263.
-
(1989)
Anti-Cancer Drug Des.
, vol.4
, pp. 241-263
-
-
Denny, W.A.1
-
2
-
-
0024316466
-
DNA topoisomerase poisons as antitumor drugs
-
Liu, L. F. DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem. 1989, 58, 351-375.
-
(1989)
Annu. Rev. Biochem.
, vol.58
, pp. 351-375
-
-
Liu, L.F.1
-
3
-
-
0030022599
-
The 1′-substituent on the anilino ring of the antitumor drug amsacrine is a critical element for topoisomerase II inhibition and cytotoxicity
-
Rene, B.; Fosse, P.; Khelifa, T.; Jacquemin-Sablon, A.; Bailly, C. The 1′-substituent on the anilino ring of the antitumor drug amsacrine is a critical element for topoisomerase II inhibition and cytotoxicity. Mol. Pharmacol. 1996, 49, 343-350.
-
(1996)
Mol. Pharmacol.
, vol.49
, pp. 343-350
-
-
Rene, B.1
Fosse, P.2
Khelifa, T.3
Jacquemin-Sablon, A.4
Bailly, C.5
-
4
-
-
0016771313
-
Potential antitumor agents. 16. 4′-(Acridin-9-ylamino) methanesulfonanilides
-
Cain, B. F.; Atwell, G. J.; Denny, W. A. Potential antitumor agents. 16. 4′-(Acridin-9-ylamino)methanesulfonanilides. J. Med. Chem. 1975, 78, 1110-1117.
-
(1975)
J. Med. Chem.
, vol.78
, pp. 1110-1117
-
-
Cain, B.F.1
Atwell, G.J.2
Denny, W.A.3
-
5
-
-
0028000647
-
Stimulation of site-specific topoisomerase II-mediated DNA cleavage by an N-methylpyrrolecarboxamide-anilinoacridine conjugate: Relation to DNA binding
-
Fossé, P.; René, B.; Saucier, J.-M.; Hénichart, J.-P.; Waring, M. J.; Colson, P.; Houssier, C.; Bailly, C. Stimulation of site-specific topoisomerase II-mediated DNA cleavage by an N- methylpyrrolecarboxamide-anilinoacridine conjugate: relation to DNA binding. Biochemistry 1994, 33, 9865-9874.
-
(1994)
Biochemistry
, vol.33
, pp. 9865-9874
-
-
Fossé, P.1
René, B.2
Saucier, J.-M.3
Hénichart, J.-P.4
Waring, M.J.5
Colson, P.6
Houssier, C.7
Bailly, C.8
-
6
-
-
0023493551
-
Role of DNA intercalation in the inhibition of purified mouse leukemia (L1210) DNA topoisomerase II by 9-aminoacridines
-
Pommier, Y.; Covey, J.; Kerrigan, D.; Mattes, W.; Markovits, J.; et al. Role of DNA intercalation in the inhibition of purified mouse leukemia (L1210) DNA topoisomerase II by 9-aminoacridines. Biochem. Pharmacol. 1987, 36, 3477-3486.
-
(1987)
Biochem. Pharmacol.
, vol.36
, pp. 3477-3486
-
-
Pommier, Y.1
Covey, J.2
Kerrigan, D.3
Mattes, W.4
Markovits, J.5
-
7
-
-
0026721021
-
P-(Methylsulfmyl)phenyl nitrogen mustard as a novel bioreductive prodrug selective against hypoxic tumors
-
Kwon, C. H.; Blanco, D. R.; Baturay, N. p-(Methylsulfmyl)phenyl nitrogen mustard as a novel bioreductive prodrug selective against hypoxic tumors. J. Med. Chem. 1992, 35, 2137-2139.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2137-2139
-
-
Kwon, C.H.1
Blanco, D.R.2
Baturay, N.3
-
8
-
-
0034597583
-
Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins
-
Sun, Z. Y.; Botros, E.; Su, A. D.; Kim, Y.; Wang, E.; et al. Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins. J. Med. Chem. 2000, 43, 4160-4168.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 4160-4168
-
-
Sun, Z.Y.1
Botros, E.2
Su, A.D.3
Kim, Y.4
Wang, E.5
-
9
-
-
0025027925
-
DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: Consequences of varying the length of the linker chain
-
Valu, K. K.; Gourdie, T. A.; Boritzki, T. J.; Gravatt, G. L.; Baguley, B. C.; et al. DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain. J. Med. Chem. 1990, 33, 3014-3019.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 3014-3019
-
-
Valu, K.K.1
Gourdie, T.A.2
Boritzki, T.J.3
Gravatt, G.L.4
Baguley, B.C.5
-
10
-
-
0016187060
-
Potential antitumor agents. 14. Acridylmethanesulfonanilides
-
Cain, B. F.; Seelye, R. N.; Atwell, G. J. Potential antitumor agents. 14. Acridylmethanesulfonanilides. J. Med. Chem. 1974, 17, 922-930.
-
(1974)
J. Med. Chem.
, vol.17
, pp. 922-930
-
-
Cain, B.F.1
Seelye, R.N.2
Atwell, G.J.3
-
11
-
-
0028877191
-
Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring
-
Bartroli, J.; Turmo, E.; Alguero, M.; Boncompte, E.; Vericat, M. L.; et al. Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. J. Med. Chem. 1995, 38, 3918-3932.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 3918-3932
-
-
Bartroli, J.1
Turmo, E.2
Alguero, M.3
Boncompte, E.4
Vericat, M.L.5
-
12
-
-
0018214707
-
Synthesis and quantitative structure-activity relationships of some antibacterial 3-formylrifamycin SV N-(4-substituted phenyl) piperazinoacethydrazones
-
Kiritsy, J. A.; Yung, D. K.; Mahony, D. E. Synthesis and quantitative structure-activity relationships of some antibacterial 3-formylrifamycin SV N-(4-substituted phenyl)piperazinoacethydrazones. J. Med. Chem. 1978, 21, 1301-1307.
-
(1978)
J. Med. Chem.
, vol.21
, pp. 1301-1307
-
-
Kiritsy, J.A.1
Yung, D.K.2
Mahony, D.E.3
-
13
-
-
0022492516
-
Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells
-
Fracasso, P. M.; Sartorelli, A. C. Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells. Cancer Res. 1986, 46, 3939-3944.
-
(1986)
Cancer Res.
, vol.46
, pp. 3939-3944
-
-
Fracasso, P.M.1
Sartorelli, A.C.2
-
14
-
-
0000398062
-
A Simple preparation of phenols from Diazonium ions via the generation and oxidation of aryl radicals by copper salts
-
Cohen, T.; Fietz, A. G.; Miser, J. R. A Simple preparation of phenols from Diazonium ions via the generation and oxidation of aryl radicals by copper salts. J. Org. Chem. 1977, 42, 2053-2058.
-
(1977)
J. Org. Chem.
, vol.42
, pp. 2053-2058
-
-
Cohen, T.1
Fietz, A.G.2
Miser, J.R.3
-
15
-
-
24744467367
-
3-Bromo-4-hydroxytoluene
-
Horning, E. C., Ed.; Wiley: New York
-
Ungnade, H. E.; Orwoll, E. F. 3-Bromo-4-hydroxytoluene. Organic Syntheses; Horning, E. C., Ed.; Wiley: New York, 1955; Collect. Vol. III, pp 130-131.
-
(1955)
Organic Syntheses
, vol.3
, pp. 130-131
-
-
Ungnade, H.E.1
Orwoll, E.F.2
-
16
-
-
0000601626
-
The mechanism of N-alkylation of weak N-H-acids by phase transfer catalysts
-
Dehmlow, E. V.; Thieser, R. The mechanism of N-alkylation of weak N-H-acids by phase transfer catalysts. Tetrahedron Lett. 1985, 26, 297-300.
-
(1985)
Tetrahedron Lett.
, vol.26
, pp. 297-300
-
-
Dehmlow, E.V.1
Thieser, R.2
-
17
-
-
0000057992
-
Peroxytrifluoroacetic acid. A convenient reagent for the preparation of sulfoxides and sulfones
-
Venier, C. G.; Squires, T. G.; Chen, Y.-Y.; Hussmann, G. P.; Shei, J. C.; et al. Peroxytrifluoroacetic acid. A convenient reagent for the preparation of sulfoxides and sulfones. J. Org. Chem. 1982, 47, 3773-3774.
-
(1982)
J. Org. Chem.
, vol.47
, pp. 3773-3774
-
-
Venier, C.G.1
Squires, T.G.2
Chen, Y.-Y.3
Hussmann, G.P.4
Shei, J.C.5
-
18
-
-
0014276040
-
The use of β-methylsulphonylethyl esters for the protection of carboxyl groups in peptide synthesis: Removal through the β -ethylsulphonylethyl ester
-
Hardy, P. M.; Rydon, H. N.; Thompson, R. C. The use of β-methylsulphonylethyl esters for the protection of carboxyl groups in peptide synthesis: removal through the β -ethylsulphonylethyl ester. Tetrahedron Lett. 1968, 9, 2525-2526.
-
(1968)
Tetrahedron Lett.
, vol.9
, pp. 2525-2526
-
-
Hardy, P.M.1
Rydon, H.N.2
Thompson, R.C.3
-
19
-
-
0028360131
-
Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum
-
Gamage, S. A.; Tepsiri, N.; Wilairat, P.; Wojcik, S. J.; Figgitt, D. P.; Ralph, R. K.; Denny, D. A. Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum. J. Med. Chem. 1994, 37, 1486-1494.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1486-1494
-
-
Gamage, S.A.1
Tepsiri, N.2
Wilairat, P.3
Wojcik, S.J.4
Figgitt, D.P.5
Ralph, R.K.6
Denny, D.A.7
-
20
-
-
0024278459
-
Inhibitors of DNA topoisomerases
-
Drlica, K.; Franco, R. J. Inhibitors of DNA topoisomerases. Biochemistry 1988, 27, 2253-2259.
-
(1988)
Biochemistry
, vol.27
, pp. 2253-2259
-
-
Drlica, K.1
Franco, R.J.2
-
21
-
-
0021687360
-
Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1
-
Keyes, S. R.; Fracasso, P. M.; Heimbrook, D. C.; Rockwell, S.; Sligar, S. G.; et al. Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1. Cancer Res. 1984, 44, 5638-5643.
-
(1984)
Cancer Res.
, vol.44
, pp. 5638-5643
-
-
Keyes, S.R.1
Fracasso, P.M.2
Heimbrook, D.C.3
Rockwell, S.4
Sligar, S.G.5
-
22
-
-
0019860652
-
Potential antitumor agents. 35. Quantitative relationships between antitumor (L1210) potency and DNA binding for 4′-(9-acridinylamino) methanesulfon-m-anisidide analogues
-
Baguley, B. C.; Denny, W. A.; Atwell, G. J.; Cain, B. F. Potential antitumor agents. 35. Quantitative relationships between antitumor (L1210) potency and DNA binding for 4′-(9-acridinylamino)methanesulfon-m-anisidide analogues. J. Med. Chem. 1981, 24, 520-525.
-
(1981)
J. Med. Chem.
, vol.24
, pp. 520-525
-
-
Baguley, B.C.1
Denny, W.A.2
Atwell, G.J.3
Cain, B.F.4
-
23
-
-
0026546254
-
Relative activity of structural analogues of amsacrine against human leukemia cell lines containing amsacrine-sensitive or -resistant forms of topoisomerase II: Use of computer simulations in new drug development
-
Zwelling, L. A.; Mitchell, M. J.; Satitpunwaycha, P.; Mayes, J.; Altschuler, E.; et al. Relative activity of structural analogues of amsacrine against human leukemia cell lines containing amsacrine-sensitive or -resistant forms of topoisomerase II: use of computer simulations in new drug development. Cancer Res. 1992, 52, 209-217.
-
(1992)
Cancer Res.
, vol.52
, pp. 209-217
-
-
Zwelling, L.A.1
Mitchell, M.J.2
Satitpunwaycha, P.3
Mayes, J.4
Altschuler, E.5
-
24
-
-
0025334763
-
Differences between normal and ras-transformed NIH-3T3 cells in expression of the 170kD and 180kD forms of topoisomerase II
-
Woessner, R. D.; Chung, T. D.; Hofmann, G. A.; Mattern, M. R.; Mirabelli, C. K.; et al. Differences between normal and ras-transformed NIH-3T3 cells in expression of the 170kD and 180kD forms of topoisomerase II. Cancer Res. 1990, 50, 2901-2908.
-
(1990)
Cancer Res.
, vol.50
, pp. 2901-2908
-
-
Woessner, R.D.1
Chung, T.D.2
Hofmann, G.A.3
Mattern, M.R.4
Mirabelli, C.K.5
-
25
-
-
4844231439
-
The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual properties
-
Lemke, K.; Poindessous, V.; Skladanowski, A.; Larsen, A. K. The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual properties. Mol. Pharmacol 2004, 66, 1035-1042.
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 1035-1042
-
-
Lemke, K.1
Poindessous, V.2
Skladanowski, A.3
Larsen, A.K.4
-
26
-
-
0442282173
-
Differences in the longevity of topo IIalpha and topo IIbeta drug-stabilized cleavable complexes and the relationship to drug sensitivity
-
Errington, F.; Willmore, E.; Leontiou, C.; Tilby, M. J.; Austin, C. A. Differences in the longevity of topo IIalpha and topo IIbeta drug-stabilized cleavable complexes and the relationship to drug sensitivity. Cancer Chemother. Pharmacol. 2004, 53, 155-162.
-
(2004)
Cancer Chemother. Pharmacol.
, vol.53
, pp. 155-162
-
-
Errington, F.1
Willmore, E.2
Leontiou, C.3
Tilby, M.J.4
Austin, C.A.5
-
27
-
-
0037419721
-
Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells
-
Blasiak, J.; Gloc, E.; Drzewoski, J.; Wozniak, K.; Zadrozny, M.; et al. Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells. Mutat. Res. 2003, 535, 25-34.
-
(2003)
Mutat. Res.
, vol.535
, pp. 25-34
-
-
Blasiak, J.1
Gloc, E.2
Drzewoski, J.3
Wozniak, K.4
Zadrozny, M.5
-
28
-
-
0021766898
-
Deoxyribonucleic acid breaks produced by 4′-(9-acridinylamino) methanesulfon-m-anisidide and copper
-
Wong, A.; Huang, C.-H.; Crooke, S. T. Deoxyribonucleic acid breaks produced by 4′-(9-acridinylamino)methanesulfon-m-anisidide and copper. Biochemistry 1984, 23, 2939-2945.
-
(1984)
Biochemistry
, vol.23
, pp. 2939-2945
-
-
Wong, A.1
Huang, C.-H.2
Crooke, S.T.3
-
29
-
-
0345687458
-
Mechanisms of action of DNA intercalating acridine-based drugs: How important are contributions from electron transfer and oxidative stress?
-
Baguley, B. C.; Wakelin, L. P.; Jacintho, J. D.; Kovacic, P. Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress? Curr. Med. Chem. 2003, 10, 2643-2649.
-
(2003)
Curr. Med. Chem.
, vol.10
, pp. 2643-2649
-
-
Baguley, B.C.1
Wakelin, L.P.2
Jacintho, J.D.3
Kovacic, P.4
|