Pathophysiological role of vascular endothelial growth factor in the remnant kidney

Nephron - Experimental Nephrology

Volumn 101, Issue 1, 2005, Pages

  Schrijvers, Bieke F ^a   Flyvbjerg, Allan ^c   Tilton, Ronald G ^e   Rasch, Ruth ^d   Lameire, Norbert H ^a   De Vriese, An S ^a,b  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b Renal Unit   (Belgium)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d AARHUS UNIVERSITY   (Denmark)

^e University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Chronic renal failure; Creatinine clearance; Cryo ablation; Glomerular volume; Haematocrit; Remnant kidney model; Subtotal nephrectomy; Urea; Urinary albumin excretion; Vascular endothelial growth factor

Indexed keywords

ALBUMIN; CREATININE; ERYTHROPOIETIN; UREA; VASCULOTROPIN; VASCULOTROPIN ANTIBODY;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; GLOMERULOPATHY; KIDNEY FUNCTION; KIDNEY INJURY; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; RAT; UREA BLOOD LEVEL;

ANIMALS; ANTIBODIES; CELL PROLIFERATION; FEMALE; FIBROSIS; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; KIDNEY; KIDNEY FAILURE, CHRONIC; NEPHRECTOMY; RATS; RATS, WISTAR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 23844548897     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000086034     Document Type: Article

References (27)

1. Kang DH, Hughes J, Mazzali M, Schreiner GF, Johnson RJ: Impaired angiogenesis in the remnant kidney model. II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function. J Am Soc Nephrol 2001;12:1448-1457.
2. Kang DH, Joly AH, Oh SW, Hugo C, Kerjaschki D, Gordon KL, Mazzali M, Jefferson JA, Hughes J, Madsen KM, Schreiner GF, Johnson RJ: Impaired angiogenesis in the remnant kidney model. I. Potential role of vascular endothelial growth factor and thrombospondin-1. J Am Soc Nephrol 2001;12:1434-1447.
3. Kelly DJ, Hepper C, Wu LL, Cox AJ, Gilbert RE: Vascular endothelial growth factor expression and glomerular endothelial cell loss in the remnant kidney model. Nephrol Dial Transplant 2003;18:1286-1292.
4. Muchaneta-Kubara EC, Sayed-Ahmed N, el Nahas AM: Subtotal nephrectomy: A mosaic of growth factors. Nephrol Dial Transplant 1995;10:320-327.
5. Ferrara N, Gerber HP: The role of vascular endothelial growth factor in angiogenesis. Acta Haematol 2001;106:148-156.
6. Schrijvers BF, Flyvbjerg A, De Vriese AS: The role of vascular endothelial growth factor (VEGF) in renal pathophysiology. Kidney Int 2004;65:2003-2017.
7. De Vriese AS, Tilton RG, Elger M, Stephan CC, Kriz W, Lameire NH: Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes. J Am Soc Nephrol 2001;12:993-1000.
8. Flyvbjerg A, Dagnaes-Hansen F, De Vriese AS, Schrijvers BF, Tilton RG, Rasch R: Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody. Diabetes 2002;51:3090-3094.
9. Schrijvers BF, Rasch R, Tilton RG, Flyvbjerg A: High protein-induced glomerular hypertrophy is vascular endothelial growth factor-dependent. Kidney Int 2002;61:1600-1604.
10. Flyvbjerg A, Schrijvers BF, De Vriese AS, Tilton RG, Rasch R: Compensatory glomerular growth after unilateral nephrectomy is VEGF dependent. Am J Physiol Endocrinol Metab 2002;283:E362-E366.
11. Taes YE, Delanghe JR, De Vriese AS, Rombaut R, Van Camp J, Lameire NH: Creatine supplementation decreases homocysteine in an animal model of uremia. Kidney Int 2003;64:1331-1337.
12. Tilton RG, Kawamura T, Chang KC, Ido Y, Bjercke RJ, Stephan CC, Brock TA, Williamson JR: Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. J Clin Invest 1997;99:2192-2202.
13. Christensen C, Orskov H: Rapid screening PEG radioimmunoassay for quantification of pathological microalbuminuria. Diabet Nephrol 1984;3:92-94.
14. Gundersen HJ, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B: The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1988;96:857-881.
15. Weibel ER: Stereologic Methods: Practical Methods for Biological Morphometry. London, Academic Press, 1979, pp 51-57.
16. Kleinknecht C, Terzi F, Burtin M, Laouari D, Maniar S: Experimental models of nephron reduction: Some answers, many questions. Kidney Int Suppl 1995;49:S51-S54.
17. Lameire N, Van Biesen W, Van Landschoot M, Wang T, Heimburger O, Bergstrom J, Lindholm B, Hekking LP, Havenith CE, Beelen RH: Experimental models in peritoneal dialysis: A European experience. Kidney Int 1998;54:2194-2206.
18. Shea SM, Raskova J, Morrison AB: A stereologic study of glomerular hypertrophy in the subtotally nephrectomized rat. Am J Pathol 1978;90:201-210.
19. Bhathena DB: Glomerular basement membrane length to podocyte ratio in human nephronopenia: Implications for focal segmental glomerulosclerosis. Am J Kidney Dis 2003;41:1179-1188.
20. Fogo A, Ichikawa I: Evidence for a pathogenic linkage between glomerular hypertrophy and sclerosis. Am J Kidney Dis 1991;17:666-669.
21. Fries JW, Sandstrom DJ, Meyer TW, Rennke HG: Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat. Lab Invest 1989;60:205-218.
22. Adamczak M, Gross ML, Krtil J, Koch A, Tyralla K, Amann K, Ritz E: Reversal of glomerulosclerosis after high-dose enalapril treatment in subtotally nephrectomized rats. J Am Soc Nephrol 2003;14:2833-2842.
23. Kriz W, Kretzler M, Nagata M, Provoost AP, Shirato I, Uiker S, Sakai T, Lemley KV: A frequent pathway to glomerulosclerosis: Deterioration of tuft architecture-podocyte damage-segmental sclerosis. Kidney Blood Press Res 1996;19:245-253.
24. Adamczak M, Gross ML, Amann K, Ritz E: Reversal of glomerular lesions involves coordinated restructuring of glomerular microvasculature. J Am Soc Nephrol 2004;15:3063-3072.
25. 165 mediates glomerular endothelial repair. J Clin Invest 1999;104:913-923.
26. Sugimoto H, Hamano Y, Charytan D, Cosgrove D, Kieran M, Sudhakar A, Kalluri R: Neutralization of circulating vascular endothelial growth factor (VEGF) by and-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria. J Biol Chem 2003;278:12605-12608.
27. De Vriese AS, Tilton RG, Stephan CC, Lameire NH: Vascular endothelial growth factor is essential for hyperglycemia-induced structural and functional alterations of the peritoneal membrane. J Am Soc Nephrol 2001;12:1734-1741.