Usefulness of the addition of metformin to insulin in pediatric patients with type 1 diabetes mellitus

Pediatrics International

Volumn 47, Issue 4, 2005, Pages 430-433

  Urakami, Tatsuhiko ^a   Morimoto, Shigeo ^a   Owada, Misao ^a   Harada, Kensuke ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adolescents and young adults; Metformin; Poor glycemic control; Type 1 diabetes mellitus

Indexed keywords

HEMOGLOBIN A1C; INSULIN; METFORMIN;

ABDOMINAL DISCOMFORT; ADOLESCENT; ADULT; ANEMIA; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DIARRHEA; DRUG EFFECT; DRUG MEGADOSE; DRUG SAFETY; FEMALE; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; KETOACIDOSIS; LACTIC ACIDOSIS; LIVER DYSFUNCTION; MALE; NAUSEA; OBESITY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; BODY MASS INDEX; DIABETES MELLITUS, TYPE 1; DRUG THERAPY, COMBINATION; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; METFORMIN;

EID: 23844548753     PISSN: 13288067     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1442-200x.2005.02075.x     Document Type: Article

References (20)

1. American Diabetes Association. Type 2 diabetes in children and adolescents (Consensus Statement). Diabetes Care 2000; 23: 381-9.
2. Jones KL, Park JS, Arslanian S, Tomlinson M, Peterokova VA. Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial. Diabetes Care 2003; 25: 89-94.
3. Gerich JE. Drug therapy: oral hypoglycemic agents. N. Engl. J. Med. 1989; 321: 1231-45.
4. Bailey CJ. Biguanides NIDDM (Review). Diabetes Care 1992; 15: 755-72.
5. DeFronzo RA, Goodman AM, the Multicenter Metformin Study Group. Efficacy of metformin in NIDDM patients poorly controlled on diet alone diet plus sulfonylurea. N. Engl. J. Med. 1995; 333: 541-9.
6. Cusi K, DeFronzo RA. Metformin: a review of metabolic effects. Diabet. Rev. 1998; 6: 89-131.
7. DeFronzo RA, Hendler R, Simonson D. Insulin resistance is a prominent feature of insulin-dependent diabetes. Diabetes 1982; 31: 795-801.
8. Arslanian SA, Heil BV, Becker DJ, Drash AL. Sexual dimorfism in insulin sensitivity in adolescents with insulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 1991; 72: 920-6.
9. Yki-Jarvinen H, Makimattila S. Insulin resistance due to hyperglycemia: an adaptation protecting insulin-sensitive tissues. Diabetologia 1997; 40: S141-4.
10. DCCT Research Group. Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial. J. Pediatr. 1994; 125: 177-88.
11. Mortensen HB, Robertson KJ, Aanstoot H-J et al. Insulin management and metabolic control of type 1 diabetes mellitus in childhood and adolescence in 18 countries. Diabet. Med. 1998; 15: 752-9.
12. Coscelli C, Palmari V, Saccardi F, Alpi O, Bonora E. Evidence that metformin addition to insulin reduces an amelioration of glycaemic profile in type 1 (insulin-dependent) diabetes mellitus. Curr. Ther. Res. 1984; 35: 1058-64.
13. Janssen M, Rillaerts E, De Leeuw I. Effects of metformin on haemorheology, lipid parameters and insulin resistance in insulin-dependent diabetic patients (IDDM). Biomed. Pharmacother. 1991; 45: 363-7.
14. Meyer L, Delbachian I, Lehert P, Cugnardey N, Drouin P, Guerci B. Continuous subcutaneous insulin infusion in type 1 diabetes mellitus: insulin-sparing effect of metformin. American Diabetic Association Scientific Sessions, Abstract 1999; 1538.
15. Walravens PA, Chase PH, Klingensmith GJ, Essison M, Cornell C, Monahan K. Low dose metformin in adolescents with type 1 diabetes mellitus: a double-blind, controlled study. American Diabetes Association 60th Scientific Sessions, Abstract 2000; 128.
16. Desmangles J, Buchilis JG, Shine B, Quattrin T. Is Metformin a useful adjunct to insulin therapy in adolescents with type 1 diabetes in poor control? Endocrine Society Meeting, Abstract 2000; 1833.
17. Hamilton J, Finegood D, Cummings E, Daneman D, Zdravkovic V. Metformin as an adjunct therapy in adolescents with type 1 diabetes and insulin resistance. Diabetes Care 2003; 26: 138-43.
18. Gomez R, Mokhashi MH, Rao J et al. Metformin adjunctive therapy with insulin improves glycemic control in patients with type 1 diabetes mellitus: a pilot study. J. Pediatr. Endocrinol. Metab. 2002; 15: 1147-51.
19. Amiel SA, Sherwin RS, Simonson DC, Lauritano AA, Tamborlane WV. Impaired insulin action in puberty: a contributing factor to poor control in adolescents with diabetes. N. Engl. J. Med. 1986; 315: 215-19.
20. Wei M, Gaskill SP, Haffner SM, Stern MP. Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality: the San Antonio Heart Study. Diabetes Care 1998; 21: 1167-72.