In vivo iron and zinc deficiency diminished T- and B-selective mitogen stimulation of murine lymphoid cells through protein kinase C-mediated mechanism

Biological Trace Element Research

Volumn 104, Issue 2, 2005, Pages 173-183

  Klecha, A J ^a,b   Salgueiro, J ^a   Wald, M ^b   Boccio, J ^a   Zubillaga, M ^a   Leonardi, N M ^a   Gorelik, G ^b   Cremaschi, G A ^a,b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

B lymphocyte; Iron; Proliferation; Protein kinase C; T lymphocyte; Zinc

Indexed keywords

IRON; MITOGENIC AGENT; PROTEIN KINASE C; ZINC; CONCANAVALIN A; LIPOPOLYSACCHARIDE; PHYTOHEMAGGLUTININ; POKEWEED MITOGEN;

ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BLOOD LEVEL; BONE LEVEL; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; IMMUNITY; IRON BLOOD LEVEL; IRON DEFICIENCY; LIVER LEVEL; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ZINC BLOOD LEVEL; ZINC DEFICIENCY; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECT; IMMUNOLOGY; PHYSIOLOGY;

ANIMALIA; MURINAE; RODENTIA;

ANIMALS; B-LYMPHOCYTES; CELL PROLIFERATION; CONCANAVALIN A; FEMALE; IRON; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; PHYTOHEMAGGLUTININS; POKEWEED MITOGENS; PROTEIN KINASE C; T-LYMPHOCYTES; ZINC;

EID: 23844544487     PISSN: 01634984     EISSN: None     Source Type: Journal    
DOI: 10.1385/BTER:104:2:173     Document Type: Article

References (27)

1. J.D. Kemp, The role of iron-binding protein in lymphocyte physiology and pathology, J. Clin. Immunol. 13, 81-91 (1993).
2. M.J. Salgueiro, M. Zubillaga, A. Lysionek, et al., Zinc status and immune system relationship, Biol. Trace Element Res. 76, 193-205 (2000).
3. B.L. Vallee and K.H. Falchuk, The biochemical basis of zinc physiology, Physiol. Rev. 73, 79-118 (1993).
4. L. Rink and H. Kirchner, Zinc-altered immune function and cytokine production, J. Nutr. 130, 1407S-1411S (2000).
5. N. Wellinghausen, M. Martin, and L. Rink, Zinc inhibits interleukin-1-dependent T cell stimulation, Eur. J. Immunol. 27, 2529-2535 (1997).
6. P.J. Fraker and D.A. Lill-Elghanian, The many roles of apoptosis in immunity as modified by aging and nutritional status, J. Nutr. Health Aging 8, 56-63 (2004).
7. P.J. Fraker, L.E. King, T. Laako, and T.L. Vollmer, The dynamic link between the integrity of the immune system and zinc status, J. Nutr. 130, 1399S-1406S (2000).
8. C.L. Keen and M.E. Gershwin, Zinc deficiency and immune function, Annu. Rev. Nutr. 10, 415-431 (1990).
9. C.L. Bowlus, The role of iron in T cell development and autoimmunity, Autoimmun. Rev. 2, 73-78 (2003).
10. S.J. Oppenheimer, Iron and its relation to immunity and infectious disease, J. Nutr. 131, 616S-635S (2001).
11. G. Gorelik, M.L. Barreiro Arcos, A.J. Klecha, and G.A. Cremaschi, Differential expression of protein kinase C isoenzymes related to high nitric oxide synthase activity in a T lymphoma cell line, Biochim. Biophys. Acta 1588, 179-188 (2002).
12. A.E. Lysionek, M.B. Zubillaga, G.P. Calmanovici, et al., Modification of the ferrozine technique to analyze iron contents in different foods, Biol. Trace Element Res. 65, 87-94 (1998).
13. P.G. Reeves, F.H. Nielsen, and G.C. Pahey Jr., AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet, J. Nutr. 123, 1939-1951 (1993).
14. G.A. Cremaschi, A.M. Genaro, and L. Sterin Borda, A colchicine binding protein is involved in beta adrenoceptors and Class I antigen interaction, Mol. Immunol. 26, 601-609 (1989).
15. C.A. Cazaux, L. Sterin-Borda, G. Gorelik, and G.A. Cremaschi, Down-regulation of β adrenergic receptors induced by mitogen activation of intracellular signaling events in lymphocytes, FEBS Lett. 364, 120-124 (1995).
16. A.M. Genaro and L. Boscá L, Early signals in alloantigen induced B-cells triggering by inact cells and solubilized alloantigen, J. Immunol. 151, 1832-1843 (1993).
17. S.R. Kuvibidila, D. Kitchens, and S. Baliga, In vivo and in vitro iron deficiency reduces protein kinase C activity and traslocation in murine splenic and purified T cells, J. Cell. Biochem. 74, 468-478 (1999).
18. C.L. Keen, L.A. Hanna, L. Lanoue, J.Y. Uriu-Adams, R.B. Rucker, and M.S. Clegg, Developmental consequences of trace mineral deficiencies in rodents: acute and long-term effects, J. Nutr. 133, 1477S-1480S (2003).
19. S.R. Kuvidila, C. Porretta, B. Surendra Baliga, and L.E. Leiva, Reduced thymocyte proliferation but not increased apoptosis as a possible cause of thymus atrophy in iron deficient mice, Br. J. Nutr. 86, 157-162 (2001).
20. S.R. Kuvibidila, C. Porretta, and B.S. Baliga, Iron deficiency alters the progression of mitogen-treated murine splenic lymphocytes through the cell cycle, J. Nutr. 131, 2028-2033 (2001).
21. A.Q. Truong-Tran, L.H. Ho, F. Chai, and P.D. Zalewski, Cellular zinc fluxes and the regulation of apoptosis/gene-directed cell death, J. Nutr. 130, 1459S-1466S (2000).
22. lck, a zinc-finger signal transduction protein, is elevated by dietary zinc deficiency and diet restriction in mice, J. Nutr, 129, 620-627 (1999).
23. S.R. Kuvibidila, B. Surendra Baliga, R.P. Warrier, and R.M. Suskind, Iron deficiency reduces the hydrolisis of cell membrane phosphatidyl inositol-4,5-bisphosphate during splenic lymphocyte activation in C57BL/6 mice, J Nutr. 128, 1077-1083 (1998).
24. M. Kirchgessner, C. Moser, and H.P. Roth, Activity and subcellular distribution of protein kinase C (PKC) in muscle and brain of force-fed zinc-deficient rats, Biol. Trace Element Res. 52, 273-280 (1996).
25. X.B. Cen, R.S. Wang, and H. Wang, Apoptosis induced by zinc deficiency in rat osteoblast: possible involvement of protein kinase C, Biomed. Environ. Sci. 12, 161-169 (1999).
26. S.S. Chou, M.S. Clegg, T.Y. Momma, et al., Alterations in protein kinase C activity and processing during zinc deficiency-induced cell death, Biochem J. 383, 63-71 (2004).
27. B. Sandstrom, Micronutrient interactions: effects on absorption and bioavailability, Br. J. Nutr. 85, S181-S185 (2001).